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LpxA bacterial transferase hexapeptide repeat-containing protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 829075, updated on 18-Sep-2024

Summary

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Official Symbol
LpxA
Official Full Name
bacterial transferase hexapeptide repeat-containing protein
Primary source
TAIR:AT4G29540
Locus tag
AT4G29540
See related
Araport:AT4G29540
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
AtLpxA; T16L4.50; T16L4_50
Summary
Encodes a UDP-N-acetylglucosamine acyltransferase.
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Genomic context

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See LpxA in Genome Data Viewer
Location:
chromosome: 4
Exon count:
9
Sequence:
Chromosome: 4; NC_003075.7 (14497560..14500504)

Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene arginine methyltransferase 11 Neighboring gene nucleophosmin Neighboring gene Pyridoxal phosphate phosphatase-related protein Neighboring gene ncRNA Neighboring gene uncharacterized protein Neighboring gene hypothetical protein (DUF626)

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Activity and crystal structure of Arabidopsis thaliana UDP-N-acetylglucosamine acyltransferase. Joo SH, et al. Biochemistry, 2012 May 29. PMID 22545860, Free PMC Article
  2. Pathway for lipid A biosynthesis in Arabidopsis thaliana resembling that of Escherichia coli. Li C, et al. Proc Natl Acad Sci U S A, 2011 Jul 12. PMID 21709257, Free PMC Article
  3. In-depth temporal transcriptome profiling reveals a crucial developmental switch with roles for RNA processing and organelle metabolism that are essential for germination in Arabidopsis. Narsai R, et al. Plant Physiol, 2011 Nov. PMID 21908688, Free PMC Article
  4. Advanced proteomic analyses yield a deep catalog of ubiquitylation targets in Arabidopsis. Kim DY, et al. Plant Cell, 2013 May. PMID 23667124, Free PMC Article
  5. Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana. Mayer K, et al. Nature, 1999 Dec 16. PMID 10617198

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_001036672.2
NM_119099.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within lipid X metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chloroplast ISM
Inferred from Sequence Model
more info
  
located_in cytoplasm ISM
Inferred from Sequence Model
more info
  
located_in mitochondrion HDA PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
bacterial transferase hexapeptide repeat-containing protein
NP_001031749.1
  • bacterial transferase hexapeptide repeat-containing protein; FUNCTIONS IN: acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity, transferase activity; INVOLVED IN: lipid biosynthetic process; EXPRESSED IN: 7 plant structures; EXPRESSED DURING: 6 growth stages; CONTAINS InterPro DOMAIN/s: Trimeric LpxA-like (InterPro:IPR011004), Bacterial transferase hexapeptide repeat (InterPro:IPR001451), Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase (InterPro:IPR010137); BEST Arabidopsis thaliana protein match is: Trimeric LpxA-like enzymes superfamily protein (TAIR:AT4G05210.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
NP_194683.2
  • bacterial transferase hexapeptide repeat-containing protein; FUNCTIONS IN: acyl-[acyl-carrier-protein]-UDP-N-acetylglucosamine O-acyltransferase activity, transferase activity; INVOLVED IN: lipid biosynthetic process; EXPRESSED IN: 7 plant structures; EXPRESSED DURING: 6 growth stages; CONTAINS InterPro DOMAIN/s: Trimeric LpxA-like (InterPro:IPR011004), Bacterial transferase hexapeptide repeat (InterPro:IPR001451), Acyl-[acyl-carrier-protein]--UDP-N-acetylglucosamine O-acyltransferase (InterPro:IPR010137); BEST Arabidopsis thaliana protein match is: Trimeric LpxA-like enzymes superfamily protein (TAIR:AT4G05210.1); Has 13439 Blast hits to 13165 proteins in 2031 species: Archae - 84; Bacteria - 8805; Metazoa - 8; Fungi - 21; Plants - 66; Viruses - 3; Other Eukaryotes - 4452 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003075.7 Reference assembly

    Range
    14497560..14500504
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001341970.1 → NP_001329097.1  bacterial transferase hexapeptide repeat-containing protein [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8B6N8
    Conserved Domains (1) summary
    cl00160
    Location:12 → 230
    LbetaH; Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes ...

  2. NM_001341971.1 → NP_001329098.1  bacterial transferase hexapeptide repeat-containing protein [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8B6P1
    Conserved Domains (1) summary
    cl00160
    Location:41 → 203
    LbetaH; Left-handed parallel beta-Helix (LbetaH or LbH) domain: The alignment contains 5 turns, each containing three imperfect tandem repeats of a hexapeptide repeat motif (X-[STAV]-X-[LIV]-[GAED]-X). Proteins containing hexapeptide repeats are often enzymes ...

  3. NM_001036672.2 → NP_001031749.1  bacterial transferase hexapeptide repeat-containing protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001031749.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8H1Q9, Q9SU91
    UniProtKB/TrEMBL
    A0A178V128, A0A5S9XX16, A0A654FUF5
    Conserved Domains (1) summary
    cd03351
    Location:41 → 325
    LbH_UDP-GlcNAc_AT; UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic ...

  4. NM_119099.3 → NP_194683.2  bacterial transferase hexapeptide repeat-containing protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_194683.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A654FUF5
    Conserved Domains (2) summary
    cd03351
    Location:41 → 323
    LbH_UDP-GlcNAc_AT; UDP-N-acetylglucosamine O-acyltransferase (UDP-GlcNAc acyltransferase): Proteins in this family catalyze the transfer of (R)-3-hydroxymyristic acid from its acyl carrier protein thioester to UDP-GlcNAc. It is the first enzyme in the lipid A biosynthetic ...
    PRK05289
    Location:37 → 327
    PRK05289; UDP-N-acetylglucosamine acyltransferase; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9SU91.1

Gene LinkOut

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