FWA FLOWERING WAGENINGEN [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: FWA
Official Full Name: FLOWERING WAGENINGEN
Primary source: TAIR:AT4G25530
Locus tag: AT4G25530
See related: Araport:AT4G25530
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: FLOWERING WAGENINGEN; HDG6; HOMEODOMAIN GLABROUS 6; M7J2.100; M7J2_100
Summary: Encodes a homeodomain-containing transcription factor that controls flowering. FWA is silenced in wild type plants and reverse of the imprinted silencing causes a late flowering phenotype. FWA gene contains two tandem repeats around the transcription start site that are necessary and sufficient for silencing via DNA methylation.
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Genomic context

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See FWA in Genome Data Viewer

Location:: chromosome: 4

Exon count:: 10

Sequence:: Chromosome: 4; NC_003075.7 (13038360..13042464)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003075.7

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Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cytosine methylation of the FWA promoter promotes direct in vitro shoot regeneration in Arabidopsis thaliana.
Title: Cytosine methylation of the FWA promoter promotes direct in vitro shoot regeneration in Arabidopsis thaliana.
Inflorescence abnormalities in plants overexpressing the Arabidopsis lyrata FT (AlFT) and A. thaliana FWA (AtFWA) genes simultaneously, were studied.
Title: Inflorescence abnormalities occur with overexpression of Arabidopsis lyrata FT in the fwa mutant of Arabidopsis thaliana.
Vegetative expression of the A. thaliana FWA gene causes late flowering.
Title: Epigenetic variation in the FWA gene within the genus Arabidopsis.
the tandem repeat structure is dispensable for the epigenetic silencing of the FWA gene
Title: Evolution and control of imprinted FWA genes in the genus Arabidopsis.
Data show that the expression of FWA was repressed by Arabidopsis relatives of the human lysine-specific Demethylase1 and thus promote the floral transition.
Title: Arabidopsis relatives of the human lysine-specific Demethylase1 repress the expression of FWA and FLOWERING LOCUS C and thus promote the floral transition.
The mechanisms of FWA silencing were studied.
Title: Control of FWA gene silencing in Arabidopsis thaliana by SINE-related direct repeats.
Specific interaction of FWA with FT enabled us to use FWA protein as a specific inhibitor of FT protein function
Title: Molecular basis of late-flowering phenotype caused by dominant epi-alleles of the FWA locus in Arabidopsis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_118685.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within positive regulation of flower development	IMP Inferred from Mutant Phenotype more info	PubMed
NOT involved_in regulation of flower development	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within regulatory ncRNA-mediated gene silencing	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: FLOWERING WAGENINGEN

NP_567722.1

FLOWERING WAGENINGEN (FWA); CONTAINS InterPro DOMAIN/s: Homeobox (InterPro:IPR001356), Homeodomain-like (InterPro:IPR009057), Lipid-binding START (InterPro:IPR002913), Homeodomain-related (InterPro:IPR012287); BEST Arabidopsis thaliana protein match is: homeodomain GLABROUS 7 (TAIR:AT5G52170.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003075.7 Reference assembly

Range

13038360..13042464

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_118685.3 → NP_567722.1 FLOWERING WAGENINGEN [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_567722.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O65608, Q9FVI6, Q9M0K7

UniProtKB/TrEMBL

A0A178V2Z4, A0A5S9XW58, A0A654FSS2, B5BPE6, B5BPE7, B5BPF8, B5BPF9

Conserved Domains (4) summary

cd08875
Location:211 → 435

START_ArGLABRA2_like; C-terminal lipid-binding START domain of the Arabidopsis homeobox protein GLABRA 2 and related proteins

COG5576
Location:25 → 138

COG5576; Homeodomain-containing transcription factor [Transcription]

pfam00046
Location:42 → 96

Homeobox; Homeobox domain

cl14643
Location:479 → 632

SRPBCC; START/RHO_alpha_C/PITP/Bet_v1/CoxG/CalC (SRPBCC) ligand-binding domain superfamily