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SHD Chaperone protein htpG family protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 828520, updated on 18-Sep-2024

Summary

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Official Symbol
SHD
Official Full Name
Chaperone protein htpG family protein
Primary source
TAIR:AT4G24190
Locus tag
AT4G24190
See related
Araport:AT4G24190
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
AtHsp90-7; AtHsp90.7; HEAT SHOCK PROTEIN 90-7; HEAT SHOCK PROTEIN 90.7; HSP90.7; SHEPHERD; T22A6.20; T22A6_20
Summary
encodes an ortholog of GRP94, an ER-resident HSP90-like protein and is involved in regulation of meristem size and organization. Single and double mutant analyses suggest that SHD may be required for the correct folding and/or complex formation of CLV proteins. Lines carrying recessive mutations in this locus exhibits expanded shoot meristems, disorganized root meristems, and defective pollen tube elongation. Transcript is detected in all tissues examined and is not induced by heat. Endoplasmin supports the protein secretory pathway and has a role in proliferating tissues.
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Genomic context

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See SHD in Genome Data Viewer
Location:
chromosome: 4
Exon count:
15
Sequence:
Chromosome: 4; NC_003075.7 (12551552..12556058, complement)

Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene kinesin-like protein Neighboring gene THAUMATIN-LIKE PROTEIN 1 Neighboring gene Transcription elongation factor (TFIIS) family protein Neighboring gene RING/U-box superfamily protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. SHEPHERD is the Arabidopsis GRP94 responsible for the formation of functional CLAVATA proteins. Ishiguro S, et al. EMBO J, 2002 Mar 1. PMID 11867518, Free PMC Article
  2. Plant endoplasmin supports the protein secretory pathway and has a role in proliferating tissues. Klein EM, et al. Plant J, 2006 Dec. PMID 17059403
  3. Overexpression of AtHsp90.2, AtHsp90.5 and AtHsp90.7 in Arabidopsis thaliana enhances plant sensitivity to salt and drought stresses. Song H, et al. Planta, 2009 Mar. PMID 19148673
  4. A highly charged region in the middle domain of plant endoplasmic reticulum (ER)-localized heat-shock protein 90 is required for resistance to tunicamycin or high calcium-induced ER stresses. Chong LP, et al. J Exp Bot, 2015 Jan. PMID 25297550, Free PMC Article
  5. Expression of five AtHsp90 genes in Saccharomyces cerevisiae reveals functional differences of AtHsp90s under abiotic stresses. Song H, et al. J Plant Physiol, 2010 Sep 15. PMID 20493581

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Seedlings expressing HSP90.7(Delta22) had enhanced sensitivity to ER stress induced by tunicamycin or high concentration of calcium. Its general chaperone activity in preventing the model protein from heat-induced aggregation was not significantly affected.
    Title: A highly charged region in the middle domain of plant endoplasmic reticulum (ER)-localized heat-shock protein 90 is required for resistance to tunicamycin or high calcium-induced ER stresses.
  2. Results show that the induction expression of ABA-responsive genes under salt and drought stress was delayed by constitutive overexpression of cytosolic AtHsp90.2, but was hardly affected by that of organellar AtHsp90.5 and AtHsp90.7.
    Title: Overexpression of AtHsp90.2, AtHsp90.5 and AtHsp90.7 in Arabidopsis thaliana enhances plant sensitivity to salt and drought stresses.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_118552.4
NM_202877.1

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables ATP hydrolysis activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
  
enables ATP-dependent protein folding chaperone IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables unfolded protein binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in protein folding IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within protein secretion IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within regulation of meristem growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of meristem structural organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to endoplasmic reticulum stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to salt stress IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to water deprivation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
NOT located_in Golgi apparatus RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
located_in chloroplast HDA PubMed 
located_in chloroplast ISM
Inferred from Sequence Model
more info
  
located_in cytosol HDA PubMed 
NOT located_in cytosol RCA
inferred from Reviewed Computational Analysis
more info
 PubMed 
located_in endoplasmic reticulum HDA PubMed 
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in endoplasmic reticulum ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in mitochondrion HDA PubMed 
located_in nucleus HDA PubMed 
located_in plant-type vacuole HDA PubMed 
located_in plasma membrane HDA PubMed 
located_in plasmodesma HDA PubMed 
located_in secretory vesicle HDA PubMed 

General protein information

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Preferred Names
Chaperone protein htpG family protein
NP_194150.1
  • SHEPHERD (SHD); FUNCTIONS IN: unfolded protein binding, ATP binding; INVOLVED IN: in 8 processes; LOCATED IN: in 7 components; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 16 growth stages; CONTAINS InterPro DOMAIN/s: Chaperone protein htpG (InterPro:IPR001404), Heat shock protein Hsp90, C-terminal (InterPro:IPR020576), Heat shock protein Hsp90, N-terminal (InterPro:IPR020575), Molecular chaperone, heat shock protein, endoplasmin (InterPro:IPR015566), ATPase-like, ATP-binding domain (InterPro:IPR003594), Heat shock protein Hsp90, conserved site (InterPro:IPR019805), Ribosomal protein S5 domain 2-type fold (InterPro:IPR020568); BEST Arabidopsis thaliana protein match is: heat shock protein 90.1 (TAIR:AT5G52640.1); Has 10659 Blast hits to 10182 proteins in 2496 species: Archae - 7; Bacteria - 3605; Metazoa - 2791; Fungi - 470; Plants - 491; Viruses - 10; Other Eukaryotes - 3285 (source: NCBI BLink).
NP_974606.1
  • SHEPHERD (SHD); FUNCTIONS IN: unfolded protein binding, ATP binding; INVOLVED IN: in 8 processes; LOCATED IN: in 6 components; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 16 growth stages; CONTAINS InterPro DOMAIN/s: Chaperone protein htpG (InterPro:IPR001404), Heat shock protein Hsp90, C-terminal (InterPro:IPR020576), Heat shock protein Hsp90, N-terminal (InterPro:IPR020575), Molecular chaperone, heat shock protein, endoplasmin (InterPro:IPR015566), ATPase-like, ATP-binding domain (InterPro:IPR003594), Heat shock protein Hsp90, conserved site (InterPro:IPR019805), Ribosomal protein S5 domain 2-type fold (InterPro:IPR020568); BEST Arabidopsis thaliana protein match is: heat shock protein 90.1 (TAIR:AT5G52640.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003075.7 Reference assembly

    Range
    12551552..12556058 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_118552.4 → NP_194150.1  Chaperone protein htpG family protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_194150.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O22972, Q56Y38, Q8VY71, Q9STX5
    UniProtKB/TrEMBL
    A0A654FS92, Q8RVG8
    Conserved Domains (3) summary
    PRK05218
    Location:74 → 763
    PRK05218; heat shock protein 90; Provisional
    pfam00183
    Location:258 → 775
    HSP90; Hsp90 protein
    pfam02518
    Location:104 → 253
    HATPase_c; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase

  2. NM_202877.1 → NP_974606.1  Chaperone protein htpG family protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_974606.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A654FS92, F4JQ55, Q8RVG8
    Conserved Domains (3) summary
    PRK05218
    Location:74 → 763
    PRK05218; heat shock protein 90; Provisional
    pfam00183
    Location:258 → 775
    HSP90; Hsp90 protein
    pfam02518
    Location:104 → 253
    HATPase_c; Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9STX5.1

Gene LinkOut

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