SMO1-2 sterol C4-methyl oxidase 1-2 [Arabidopsis thaliana (thale cress)] - Gene

Summary

Official Symbol: SMO1-2
Official Full Name: sterol C4-methyl oxidase 1-2
Primary source: TAIR:AT4G22756
Locus tag: AT4G22756
See related: Araport:AT4G22756
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATSMO1; ATSMO1-2; SMO1; STEROL 4-ALPHA-METHYL-OXIDASE 1; STEROL C4-METHYL OXIDASE 1; sterol C4-methyl oxidase 1-2
Summary: Encodes a member of the SMO1 family of sterol 4alpha-methyl oxidases. More specifically functions as a 4,4-dimethyl-9beta,19-cyclopropylsterol-4alpha- methyl oxidase.
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Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

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The SMO1 Family of Sterol 4alpha-Methyl Oxidases Is Essential for Auxin- and Cytokinin-Regulated Embryogenesis.
Title: The SMO1 Family of Sterol 4α-Methyl Oxidases Is Essential for Auxin- and Cytokinin-Regulated Embryogenesis.
ACBP1 was demonstrated to co-express and interact with SMO1-2.
Title: Arabidopsis ACYL-COA-BINDING PROTEIN1 interacts with STEROL C4-METHYL OXIDASE1-2 to modulate gene expression of homeodomain-leucine zipper IV transcription factors.

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

NM_118404.5

Function	Evidence Code	Pubs
enables C-4 methylsterol oxidase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables C-4 methylsterol oxidase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within 4,4-dimethyl-9beta,19-cyclopropylsterol oxidation	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within embryo development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in fatty acid homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sterol biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within sterol biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sterol homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed

NP_567670.1

sterol C4-methyl oxidase 1-2 (SMO1-2); FUNCTIONS IN: C-4 methylsterol oxidase activity, 4,4-dimethyl-9beta,19-cyclopropylsterol-4alpha-methyl oxidase activity, catalytic activity; INVOLVED IN: sterol biosynthetic process; LOCATED IN: endoplasmic reticulum; EXPRESSED IN: 21 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Fatty acid hydroxylase (InterPro:IPR006694); BEST Arabidopsis thaliana protein match is: sterol-4alpha-methyl oxidase 1-1 (TAIR:AT4G12110.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

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