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UBL4A ubiquitin like 4A [ Homo sapiens (human) ]

Gene ID: 8266, updated on 12-Nov-2024

Summary

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Official Symbol
UBL4Aprovided by HGNC
Official Full Name
ubiquitin like 4Aprovided by HGNC
Primary source
HGNC:HGNC:12505
See related
Ensembl:ENSG00000102178 MIM:312070; AllianceGenome:HGNC:12505
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GDX; G6PD; GET5; MDY2; UBL4; TMA24; DX254E; DXS254E
Summary
Enables protein-folding chaperone binding activity. Involved in establishment of protein localization to membrane; regulation of protein stability; and ubiquitin-dependent protein catabolic process. Located in cytosol; membrane; and nucleoplasm. Part of BAT3 complex. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in heart (RPKM 16.9), brain (RPKM 12.9) and 25 other tissues See more
Orthologs
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Genomic context

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See UBL4A in Genome Data Viewer
Location:
Xq28
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (154483717..154486615, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (152720226..152723124, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (153712056..153714954, complement)

Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 50 member A Neighboring gene microRNA 6858 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 30062 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21106 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21107 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21108 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:153687524-153688076 Neighboring gene plexin A3 Neighboring gene Sharpr-MPRA regulatory region 3405 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21109 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:153707495-153707994 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 30063 Neighboring gene L antigen family member 3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:153713643-153714401 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:153714402-153715160 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 30064 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 21112 Neighboring gene solute carrier family 10 member 3 Neighboring gene RNA, 7SL, cytoplasmic 697, pseudogene

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. A "housekeeping" gene on the X chromosome encodes a protein similar to ubiquitin. Toniolo D, et al. Proc Natl Acad Sci U S A, 1988 Feb. PMID 2829204, Free PMC Article
  2. Partial purification and characterization of the messenger RNA for human glucose-6-phosphate dehydrogenase. Toniolo D, et al. Mol Biol Med, 1984 Apr. PMID 6533418
  3. GdX inhibits the occurrence and progression of breast cancer by negatively modulating the activity of STAT3. Chen Z, et al. Cancer Biol Ther, 2024 Dec 31. PMID 39487760, Free PMC Article
  4. The C-terminus of Ubl4A is critical for pro-death activity and association with the Arp2/3 complex. Yao Q, et al. Biochem Biophys Res Commun, 2018 Sep 18. PMID 30146258, Free PMC Article
  5. UBL4A inhibits autophagy-mediated proliferation and metastasis of pancreatic ductal adenocarcinoma via targeting LAMP1. Chen H, et al. J Exp Clin Cancer Res, 2019 Jul 9. PMID 31288830, Free PMC Article

See all (118) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. GdX inhibits the occurrence and progression of breast cancer by negatively modulating the activity of STAT3.
    Title: GdX inhibits the occurrence and progression of breast cancer by negatively modulating the activity of STAT3.
  2. miR-34b-3p protects against acute kidney injury in sepsis mice via targeting ubiquitin-like protein 4A.
    Title: miR-34b-3p protects against acute kidney injury in sepsis mice via targeting ubiquitin-like protein 4A.
  3. a novel positive feedback regulation of UBL4A in innate immune response combating virus invasion by enhancing the K63-linked ubiquitination of TRAF6.
    Title: UBL4A Augments Innate Immunity by Promoting the K63-Linked Ubiquitination of TRAF6.
  4. UBL4A is a novel autophagy inhibitor and tumor suppressor in PDAC. Mechanistically, UBL4A is involved in late stage autophagy, particularly in lysosomal dysfunction, causing impaired degradation of autophagosomes.
    Title: UBL4A inhibits autophagy-mediated proliferation and metastasis of pancreatic ductal adenocarcinoma via targeting LAMP1.
  5. The single point mutation of an aspartic acid to alanine (D122A) in the Ubl4A C-terminus abolishes its ability to bind the Arp2/3 complex. This mutation also destabilizes Ubl4A proteins susceptible to protease degradation. Importantly, ectopic expression of wild-type Ubl4A can induce cell death in colon cancer cells, but such pro-death activity is diminished in the D122A mutant.
    Title: The C-terminus of Ubl4A is critical for pro-death activity and association with the Arp2/3 complex.
  6. The authors identify USP13 as a gp78-associated deubiquitinase that eliminates ubiquitin conjugates from Ubl4A to maintain the functionality of Bag6.
    Title: USP13 antagonizes gp78 to maintain functionality of a chaperone in ER-associated degradation.
  7. Data show that molecular chaperone BAG6_ubiquitin-like domain (UBL) and ubiquitin-like 4A UBL4A_UBL compete for the same binding site on N-terminal dimerisation domain of SGTA protein (SGTA_NT).
    Title: Solution structure of the SGTA dimerisation domain and investigation of its interactions with the ubiquitin-like domains of BAG6 and UBL4A.
  8. Both TRC35 and Ubl4A have distinct C-terminal binding sites on Bag6 defining a minimal Bag6 complex.
    Title: Bag6 complex contains a minimal tail-anchor-targeting module and a mock BAG domain.
  9. Data indicate that BCL2-associated athanogene 6 (BAG6) appears to be the central component for the process, as depletion of BAG6 leads to the loss of both UBL4A and GET4 proteins and resistance to cell killing by DNA-damaging agents.
    Title: Nuclear BAG6-UBL4A-GET4 complex mediates DNA damage signaling and cell death.
  10. Data indicate that the Bag6-Ubl4A-Trc35 complex is localized to the endoplasmic reticulum (ER) membrane to regulate ER-associated degradation (ERAD).
    Title: A ubiquitin-like domain recruits an oligomeric chaperone to a retrotranslocation complex in endoplasmic reticulum-associated degradation.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Vif vif HIV-1 Vif is identified to have a physical interaction with ubiquitin-like 4A (UBL4A) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein-folding chaperone binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein-folding chaperone binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables ubiquitin-like protein transferase activity TAS
Traceable Author Statement
more info
 PubMed 
Process Evidence Code Pubs
involved_in post-translational protein targeting to endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in post-translational protein targeting to endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein modification process TAS
Traceable Author Statement
more info
 PubMed 
involved_in regulation of protein stability IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in tail-anchored membrane protein insertion into ER membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in tail-anchored membrane protein insertion into ER membrane IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in tail-anchored membrane protein insertion into ER membrane IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
part_of BAT3 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of BAT3 complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of BAT3 complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol NAS
Non-traceable Author Statement
more info
 PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
ubiquitin-like protein 4A
Names
ubiquitin-like 4
ubiquitin-like protein GDX

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_014235.5 → NP_055050.1  ubiquitin-like protein 4A

    See identical proteins and their annotated locations for NP_055050.1

    Status: VALIDATED

    Source sequence(s)
    BC043346, BM711450, CK826435, DA012854, DR003955
    Consensus CDS
    CCDS14754.1
    UniProtKB/Swiss-Prot
    P11441, Q5HY80
    Related
    ENSP00000358674.4, ENST00000369660.9
    Conserved Domains (2) summary
    cd01807
    Location:1 → 72
    Ubl_UBL4A_like; ubiquitin-like (Ubl) domain found in ubiquitin-like proteins UBL4A and similar proteins
    pfam17840
    Location:96 → 142
    Tugs; Tethering Ubl4a to BAGS domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

    Range
    154483717..154486615 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060947.1 Alternate T2T-CHM13v2.0

    Range
    152720226..152723124 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P11441.1 GenPept UniProtKB/Swiss-Prot:P11441

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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