FTA farnesyltransferase A [Arabidopsis thaliana (thale cress)] - Gene

Summary

Official Symbol: FTA
Official Full Name: farnesyltransferase A
Primary source: TAIR:AT3G59380
Locus tag: AT3G59380
See related: Araport:AT3G59380
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATFTA; farnesyltransferase A; FARNESYLTRANSFERASE A; FARNESYLTRANSFERASE SUBUNIT A; PFT/PGGT-IALPHA; PLP; PLURIPETALA
Summary: Encodes the alpha-subunit shared between protein farnesyltransferase and protein geranylgeranyltransferase-I. Involved in protein prenylation: covalent attachment of the C-15 isoprene farnesyl or the C-20 isoprene geranylgeranyl groups to the C-terminal end of some proteins. Involved in shoot and flower meristem homeostasis, and response to ABA and drought. Also regulates leaf cell shape. Mutant is epistatic to era1.
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Chromosome 3 - NC_003074.8 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

PFT exhibits broad specificity for CaaX substrates
Title: The CaaX specificities of Arabidopsis protein prenyltransferases explain era1 and ggb phenotypes.
Used to demonstrate the feasibility of bimolecular fluorescence complementation in plants.
Title: Detection of protein-protein interactions in plants using bimolecular fluorescence complementation.

Submit: New GeneRIF Correction

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

NM_115800.6

Function	Evidence Code	Pubs
enables CAAX-protein geranylgeranyltransferase activity	IEA Inferred from Electronic Annotation more info
enables farnesyltranstransferase activity	TAS Traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein farnesyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein geranylgeranyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein heterodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables protein prenyltransferase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within negative regulation of abscisic acid-activated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein farnesylation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within protein farnesylation	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within protein geranylgeranylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within protein prenylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of cell shape	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of meristem development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to water deprivation	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of CAAX-protein geranylgeranyltransferase complex	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info

NP_567084.1

farnesyltransferase A (FTA); CONTAINS InterPro DOMAIN/s: Protein prenyltransferase (InterPro:IPR008940), Protein prenyltransferase, alpha subunit (InterPro:IPR002088); BEST Arabidopsis thaliana protein match is: RAB geranylgeranyl transferase alpha subunit 1 (TAIR:AT4G24490.2); Has 1351 Blast hits to 1070 proteins in 249 species: Archae - 32; Bacteria - 58; Metazoa - 584; Fungi - 296; Plants - 191; Viruses - 0; Other Eukaryotes - 190 (source: NCBI BLink).