BT2 BTB and TAZ domain protein 2 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: BT2
Official Full Name: BTB and TAZ domain protein 2
Primary source: TAIR:AT3G48360
Locus tag: AT3G48360
See related: Araport:AT3G48360
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATBT2; BTB and TAZ domain protein 2
Summary: encodes a protein (BT2) that is an essential component of the TAC1-mediated telomerase activation pathway. Acts redundantly with BT3 and BT1 during female gametophyte development and with BT3 during male gametophyte development. BT2 also mediates multiple responses to nutrients, stresses, and hormones.
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Genomic context

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See BT2 in Genome Data Viewer

Location:: chromosome: 3

Exon count:: 5

Sequence:: Chromosome: 3; NC_003074.8 (17907767..17910738, complement)

Chromosome 3 - NC_003074.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

the roles of BT2-interacting partners GTE9 and GTE11, bromodomain and extraterminal-domain proteins of Global Transcription Factor Group E, in BT2-mediated responses to sugars and hormones, are reported.
Title: Bromodomain proteins GTE9 and GTE11 are essential for specific BT2-mediated sugar and ABA responses in Arabidopsis thaliana.
direct activation of BT1 and BT2 by NLP transcriptional activators is a key component of the molecular mechanism underlying the nitrate response in Arabidopsis
Title: Direct transcriptional activation of BT genes by NLP transcription factors is a key component of the nitrate response in Arabidopsis.
BT1 and BT2 act as conserved negative regulators of nitrate uptake genes and nitrogen use efficiency in plants
Title: Members of BTB Gene Family of Scaffold Proteins Suppress Nitrate Uptake and Nitrogen Use Efficiency.
BT1, BT2 and BT3 act redundantly during gametophyte development.
Title: BTB and TAZ domain scaffold proteins perform a crucial function in Arabidopsis development.
BT2 is a central component of an interconnected signaling network that detects and responds to multiple inputs.
Title: BT2, a BTB protein, mediates multiple responses to nutrients, stresses, and hormones in Arabidopsis.
BT2, a protein with BTB, TAZ, and calmodulin binding domains, is an essential component of the TAC1-mediated telomerase activation pathway. [BT2]
Title: Regulation of telomerase in Arabidopsis by BT2, an apparent target of TELOMERASE ACTIVATOR1.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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NM_001339366.1

Supported by ESTs:

NM_001339367.1

Supported by ESTs:

NM_114697.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
contributes_to DNA-binding transcription factor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables calmodulin binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in abscisic acid-activated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in auxin-activated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within circadian rhythm	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within embryo sac development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within pollen development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of DNA-templated transcription	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within regulation of telomere maintenance	IPI Inferred from Physical Interaction more info	PubMed
involved_in response to abscisic acid	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to auxin	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to carbohydrate	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to cold	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hydrogen peroxide	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to jasmonic acid	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to nitrate	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to salicylic acid	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to salt stress	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to wounding	IEP Inferred from Expression Pattern more info	PubMed
involved_in sugar mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	ISM Inferred from Sequence Model more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: BTB and TAZ domain protein 2

NP_566902.1

BTB and TAZ domain protein 2 (BT2); CONTAINS InterPro DOMAIN/s: BTB/POZ (InterPro:IPR013069), Zinc finger, TAZ-type (InterPro:IPR000197), BTB/POZ fold (InterPro:IPR011333), Kelch related (InterPro:IPR013089), BTB/POZ-like (InterPro:IPR000210); BEST Arabidopsis thaliana protein match is: BTB and TAZ domain protein 1 (TAIR:AT5G63160.1); Has 1199 Blast hits to 1199 proteins in 89 species: Archae - 0; Bacteria - 0; Metazoa - 703; Fungi - 0; Plants - 445; Viruses - 2; Other Eukaryotes - 49 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003074.8 Reference assembly

Range

17907767..17910738 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_114697.4 → NP_566902.1 BTB and TAZ domain protein 2 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_566902.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q94BN0, Q9STL6

UniProtKB/TrEMBL

A0A5S9XIX4, A0A654FHJ3

Conserved Domains (4) summary

smart00225
Location:35 → 132

BTB; Broad-Complex, Tramtrack and Bric a brac

cd14734
Location:138 → 200

SPOP_C; BACK-like Domain C-terminal to BTB in speckle-type POZ protein (SPOP) and similar proteins

pfam02135
Location:258 → 312

zf-TAZ; TAZ zinc finger

cl02518
Location:34 → 132

BTB; BTB/POZ domain
NM_001339366.1 → NP_001326127.1 BTB and TAZ domain protein 2 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1I9LNB8, A0A5S9XIX4, A0A654FHJ3

Conserved Domains (3) summary

cd18313
Location:33 → 138

BTB_POZ_BT; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Arabidopsis thaliana BTB/POZ and TAZ domain-containing proteins, BT1-5

pfam02135
Location:220 → 312

zf-TAZ; TAZ zinc finger

cl28903
Location:138 → 189

BACK; BACK (BTB and C-terminal Kelch) domain
NM_001339367.1 → NP_001326126.1 BTB and TAZ domain protein 2 [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A178VNG0, A0A1I9LNB7