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LOX2 lipoxygenase 2 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 823650, updated on 18-Sep-2024

Summary

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Official Symbol
LOX2
Official Full Name
lipoxygenase 2
Primary source
TAIR:AT3G45140
Locus tag
AT3G45140
See related
Araport:AT3G45140
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ARABIODOPSIS THALIANA LIPOXYGENASE 2; ATLOX2; lipoxygenase 2
Summary
Chloroplast lipoxygenase required for wound-induced jasmonic acid accumulation in Arabidopsis.Mutants are resistant to Staphylococcus aureus and accumulate salicylic acid upon infection.
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Genomic context

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See LOX2 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
7
Sequence:
Chromosome: 3; NC_003074.8 (16525245..16529352)

Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene TCP domain protein 16 Neighboring gene Putative membrane lipoprotein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Pseudophosphorylation of Arabidopsis jasmonate biosynthesis enzyme lipoxygenase 2 via mutation of Ser(600) inhibits enzyme activity. Kaur D, et al. J Biol Chem, 2023 Mar. PMID 36639029, Free PMC Article
  2. A chloroplast lipoxygenase is required for wound-induced jasmonic acid accumulation in Arabidopsis. Bell E, et al. Proc Natl Acad Sci U S A, 1995 Sep 12. PMID 7567995, Free PMC Article
  3. Characterization of an Arabidopsis lipoxygenase gene responsive to methyl jasmonate and wounding. Bell E, et al. Plant Physiol, 1993 Dec. PMID 8290626, Free PMC Article
  4. Caterpillar saliva interferes with induced Arabidopsis thaliana defence responses via the systemic acquired resistance pathway. Weech MH, et al. J Exp Bot, 2008. PMID 18487634, Free PMC Article
  5. Arabidopsis lipoxygenase 2 is essential for formation of green leaf volatiles and five-carbon volatiles. Mochizuki S, et al. FEBS Lett, 2016 Apr. PMID 26991128

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Arabidopsis Transcriptomics Reveals the Role of Lipoxygenase2 (AtLOX2) in Wound-Induced Responses.
    Title: Arabidopsis Transcriptomics Reveals the Role of Lipoxygenase2 (AtLOX2) in Wound-Induced Responses.
  2. Pseudophosphorylation of Arabidopsis jasmonate biosynthesis enzyme lipoxygenase 2 via mutation of Ser[600] inhibits enzyme activity.
    Title: Pseudophosphorylation of Arabidopsis jasmonate biosynthesis enzyme lipoxygenase 2 via mutation of Ser(600) inhibits enzyme activity.
  3. Arabidopsis TCX8 functions as a senescence modulator by regulating LOX2 expression.
    Title: Arabidopsis TCX8 functions as a senescence modulator by regulating LOX2 expression.
  4. Ca2+-dependent activation of AtLOX2 facilitates green leaf volatile-burst formation
    Title: Green leaf volatile-burst in Arabidopsis is governed by galactolipid oxygenation by a lipoxygenase that is under control of calcium ion.
  5. Data (including data from genetically modified plants) suggest that LOX2 activity is suppressed in intact cells but activated upon tissue damage to support rapid green leaf volatile-burst observed in wounded leaves.
    Title: Arabidopsis lipoxygenase 2 is essential for formation of green leaf volatiles and five-carbon volatiles.
  6. In conditions of red light-induced defence, Arabidopsis LOX activity and transcription levels of LOX2, LOX3, and LOX4 were both upregulated.
    Title: Phytochrome B-mediated activation of lipoxygenase modulates an excess red light-induced defence response in Arabidopsis.
  7. AtLOX-2, AtLOX-3, AtLOX-4 and AtLOX-6 are 13S-lipoxygenases.
    Title: Diversity of the enzymatic activity in the lipoxygenase gene family of Arabidopsis thaliana.
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Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_001339198.1
NM_114383.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables linoleate 13S-lipoxygenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables mRNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables salicylic acid binding HDA PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within green leaf volatile biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within jasmonic acid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within jasmonic acid biosynthetic process TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within lipid oxidation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in oxylipin biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in response to bacterium IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within response to fungus IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to herbivore IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within response to jasmonic acid IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within response to other organism TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within response to water deprivation TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within response to wounding IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to wounding IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in chloroplast HDA PubMed 
located_in chloroplast IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chloroplast ISM
Inferred from Sequence Model
more info
  
located_in chloroplast ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in chloroplast TAS
Traceable Author Statement
more info
 PubMed 
located_in chloroplast envelope HDA PubMed 
located_in chloroplast stroma HDA PubMed 
located_in chloroplast thylakoid membrane HDA PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISM
Inferred from Sequence Model
more info
  
located_in cytosol HDA PubMed 

General protein information

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Preferred Names
lipoxygenase 2
NP_566875.1
  • lipoxygenase 2 (LOX2); FUNCTIONS IN: lipoxygenase activity; INVOLVED IN: in 7 processes; LOCATED IN: chloroplast thylakoid membrane, chloroplast stroma, chloroplast, chloroplast envelope; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Lipoxygenase, iron binding site (InterPro:IPR020833), Lipoxygenase, C-terminal (InterPro:IPR013819), Lipoxygenase, LH2 (InterPro:IPR001024), Lipase/lipooxygenase, PLAT/LH2 (InterPro:IPR008976), Lipoxygenase, conserved site (InterPro:IPR020834), Lipoxygenase (InterPro:IPR000907), Lipoxygenase, plant (InterPro:IPR001246); BEST Arabidopsis thaliana protein match is: PLAT/LH2 domain-containing lipoxygenase family protein (TAIR:AT1G67560.1); Has 1459 Blast hits to 1423 proteins in 177 species: Archae - 0; Bacteria - 74; Metazoa - 524; Fungi - 48; Plants - 784; Viruses - 0; Other Eukaryotes - 29 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003074.8 Reference assembly

    Range
    16525245..16529352
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_114383.3 → NP_566875.1  lipoxygenase 2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_566875.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P38418, Q0WLR8, Q56WG6, Q8GW45, Q8W4E4, Q9M1U5
    UniProtKB/TrEMBL
    A0A178VJC0
    Conserved Domains (3) summary
    PLN02305
    Location:73 → 896
    PLN02305; lipoxygenase
    cd01751
    Location:73 → 200
    PLAT_LH2; PLAT/ LH2 domain of plant lipoxygenase related proteins. Lipoxygenases are nonheme, nonsulfur iron dioxygenases that act on lipid substrates containing one or more (Z,Z)-1,4-pentadiene moieties. In plants, the immediate products are involved in defense ...
    pfam00305
    Location:211 → 879
    Lipoxygenase; Lipoxygenase

  2. NM_001339198.1 → NP_001326504.1  lipoxygenase 2 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178VJC0, A0A1I9LPH1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38418.1

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