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FAR4 fatty acid reductase 4 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 823579, updated on 18-Sep-2024

Summary

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Official Symbol
FAR4
Official Full Name
fatty acid reductase 4
Primary source
TAIR:AT3G44540
Locus tag
AT3G44540
See related
Araport:AT3G44540
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
fatty acid reductase 4
Summary
Encodes a member of the eight-member gene family encoding alcohol-forming fatty acyl-CoA reductases (FARs) identified in Arabidopsis thaliana. Three of the FARs, FAR1 (At5g22500), FAR4 (At3g44540) and FAR5 (At3g44550), are shown to generate the fatty alcohols found in root, seed coat, and wound-induced leaf tissue.
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Genomic context

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See FAR4 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
9
Sequence:
Chromosome: 3; NC_003074.8 (16123426..16128030)

Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene miscRNA Neighboring gene histone chaperone HIRA-like protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene fatty acid reductase 5

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Suberin-associated fatty alcohols in Arabidopsis: distributions in roots and contributions to seed coat barrier properties. Vishwanath SJ, et al. Plant Physiol, 2013 Nov. PMID 24019425, Free PMC Article
  2. Three Arabidopsis fatty acyl-coenzyme A reductases, FAR1, FAR4, and FAR5, generate primary fatty alcohols associated with suberin deposition. Domergue F, et al. Plant Physiol, 2010 Aug. PMID 20571114, Free PMC Article
  3. Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana. Salanoubat M, et al. Nature, 2000 Dec 14. PMID 11130713

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data indicate that down-regulation of Arabidopsis FATTY ACYL REDUCTASE1 (FAR1), FAR4, and FAR5, which collectively produce the fatty alcohols found in suberin, reduced their levels by 70% to 80%.
    Title: Suberin-associated fatty alcohols in Arabidopsis: distributions in roots and contributions to seed coat barrier properties.
  2. FAR1, FAR4, and FAR5 generate the fatty alcohols found in root, seed coat, and wound-induced leaf tissue.
    Title: Three Arabidopsis fatty acyl-coenzyme A reductases, FAR1, FAR4, and FAR5, generate primary fatty alcohols associated with suberin deposition.
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Pathways from PubChem

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General gene information

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NM_001339152.1
NM_114322.5

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables alcohol-forming long-chain fatty acyl-CoA reductase activity IEA
Inferred from Electronic Annotation
more info
  
enables alcohol-forming very long-chain fatty acyl-CoA reductase activity IEA
Inferred from Electronic Annotation
more info
  
enables long-chain-fatty-acyl-CoA reductase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within response to salt stress IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within response to wounding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within suberin biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chloroplast ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
fatty acid reductase 4
NP_001319682.1
  • fatty acid reductase 4 (FAR4); CONTAINS InterPro DOMAIN/s: NAD(P)-binding domain (InterPro:IPR016040), Male sterility, NAD-binding (InterPro:IPR013120); BEST Arabidopsis thaliana protein match is: fatty acid reductase 1 (TAIR:AT5G22500.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
NP_190040.3
  • fatty acid reductase 4 (FAR4); CONTAINS InterPro DOMAIN/s: NAD(P)-binding domain (InterPro:IPR016040), Male sterility (InterPro:IPR004262), Male sterility, NAD-binding (InterPro:IPR013120); BEST Arabidopsis thaliana protein match is: fatty acid reductase 1 (TAIR:AT5G22500.1); Has 1944 Blast hits to 1910 proteins in 300 species: Archae - 2; Bacteria - 305; Metazoa - 993; Fungi - 183; Plants - 285; Viruses - 0; Other Eukaryotes - 176 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003074.8 Reference assembly

    Range
    16123426..16128030
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001339153.1 → NP_001327210.1  fatty acid reductase 4 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178VJU2, A0A1I9LRL6

  2. NM_114322.5 → NP_190040.3  fatty acid reductase 4 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_190040.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q2V3Q9, Q9LXN3
    UniProtKB/TrEMBL
    A0A5S9XHR2
    Conserved Domains (3) summary
    cd05236
    Location:12 → 362
    FAR-N_SDR_e; fatty acyl CoA reductases (FARs), extended (e) SDRs
    PLN02996
    Location:1 → 492
    PLN02996; fatty acyl-CoA reductase
    pfam03015
    Location:393 → 492
    Sterile; Male sterility protein

  3. NM_001339152.1 → NP_001319682.1  fatty acid reductase 4 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178VJU2, A0A1I9LRL6
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9LXN3.1

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