XPL1 S-adenosyl-L-methionine-dependent methyltransferases superfamily protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: XPL1
Official Full Name: S-adenosyl-L-methionine-dependent methyltransferases superfamily protein
Primary source: TAIR:AT3G18000
Locus tag: AT3G18000
See related: Araport:AT3G18000
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: AT3G17990; N-METHYLTRANSFERASE 1; NMT1; PEAMT; S-ADENOSYL-L-METHIONINE:PHOSPHOETHANOLAMINE N-METHYLTRANSFERASE; S-ADENOSYLMETHIONINE:PHOSPHO-ETHANOLAMINE; XIPOTL 1
Summary: Arabidopsis thaliana N-methyltransferase-like protein mRNA. Reduce transmission through pollen.
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Genomic context

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See XPL1 in Genome Data Viewer

Location:: chromosome: 3

Exon count:: 12

Sequence:: Chromosome: 3; NC_003074.8 (6154363..6157552)

Chromosome 3 - NC_003074.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Loss-of-function of DPR2/PEAMT1 resulted in root apical meristem consumption by affecting root stem cell niche, division zone, elongation and differentiation zone.[PEAMT1]
Title: Phosphoethanolamine N-methyltransferase 1 contributes to maintenance of root apical meristem by affecting ROS and auxin-regulated cell differentiation in Arabidopsis.
At3g18000 (NMT3) catalyzes the triple methylation of phosphoethanolamine to phosphocholine.NMT3 role in reproduction and seed development.
Title: NMT1 and NMT3 N-Methyltransferase Activity Is Critical to Lipid Homeostasis, Morphogenesis, and Reproduction.
Crystal structure shows the di-domain architecture.
Title: Conformational changes in the di-domain structure of Arabidopsis phosphoethanolamine methyltransferase leads to active-site formation.
Data suggests that phosphocholine (PCho) is the true mediator of upstream open reading frame 30-driven translational repression. Because XIPOTL1 is preferentially expressed in Arabidopsis root tips, higher PCho levels are found in roots than shoots.
Title: Translational regulation of Arabidopsis XIPOTL1 is modulated by phosphocholine levels via the phylogenetically conserved upstream open reading frame 30.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

Miscellaneous features

Loc: 6154434-6154511 AT3G18000.uORF1

NM_112681.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables methyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables phosphoethanolamine N-methyltransferase activity	IEA Inferred from Electronic Annotation more info
enables phosphoethanolamine N-methyltransferase activity	IGI Inferred from Genetic Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within choline biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphatidylcholine biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within phosphatidylcholine biosynthetic process	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within pollen development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pollen tube growth	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within pollen tube guidance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within post-embryonic root development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within unidimensional cell growth	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISM Inferred from Sequence Model more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: S-adenosyl-L-methionine-dependent methyltransferases superfamily protein

NP_188427.2

XIPOTL 1 (XPL1); CONTAINS InterPro DOMAIN/s: Methyltransferase type 11 (InterPro:IPR013216); BEST Arabidopsis thaliana protein match is: S-adenosyl-L-methionine-dependent methyltransferases superfamily protein (TAIR:AT1G48600.2); Has 22524 Blast hits to 22132 proteins in 2666 species: Archae - 571; Bacteria - 16701; Metazoa - 242; Fungi - 923; Plants - 574; Viruses - 10; Other Eukaryotes - 3503 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003074.8 Reference assembly

Range

6154363..6157552

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_112681.3 → NP_188427.2 S-adenosyl-L-methionine-dependent methyltransferases superfamily protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_188427.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9FR44, Q9LVH3

UniProtKB/TrEMBL

A0A178VHS8, A0A5S9XD73, A0A7G2EMT3

Conserved Domains (1) summary

PLN02336
Location:17 → 491

PLN02336; phosphoethanolamine N-methyltransferase