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KIN10 SNF1 kinase homolog 10 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 821259, updated on 18-Sep-2024

Summary

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Official Symbol
KIN10
Official Full Name
SNF1 kinase homolog 10
Primary source
TAIR:AT3G01090
Locus tag
AT3G01090
See related
Araport:AT3G01090
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
AKIN10; SNF1 kinase homolog 10; SNF1-RELATED PROTEIN KINASE; SNF1-RELATED PROTEIN KINASE 1.1; SNRK1.1; T4P13.22; T4P13_22
Summary
encodes a SNF1-related protein kinase that physically interacts with SCF subunit SKP1/ASK1 and 20S proteosome subunit PAD1. It can also interact with PRL1 DWD-containing protein. Based on in vitro degradation assays and cul4cs and prl1 mutants, there is evidence that AKIN10 is degraded in a proteasome-dependent manner, and that this depends on a CUL4-PRL1 E3 ligase
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Genomic context

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See KIN10 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
11
Sequence:
Chromosome: 3; NC_003074.8 (31145..34670, complement)

Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene WRKY DNA-binding protein 58 Neighboring gene Protein kinase superfamily protein Neighboring gene hypothetical protein 1 Neighboring gene Pyridoxal phosphate (PLP)-dependent transferases superfamily protein Neighboring gene ATP synthase E chain

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. AKIN10 activity as a cellular link between metabolism and circadian-clock entrainment in Arabidopsis thaliana. Sánchez-Villarreal A, et al. Plant Signal Behav, 2018 Mar 4. PMID 29231782, Free PMC Article
  2. Changes in the Phosphoproteome and Metabolome Link Early Signaling Events to Rearrangement of Photosynthesis and Central Metabolism in Salinity and Oxidative Stress Response in Arabidopsis. Chen Y, et al. Plant Physiol, 2015 Dec. PMID 26471895, Free PMC Article
  3. Plant SnRK1 Kinases: Structure, Regulation, and Function. Margalha L, et al. Exp Suppl, 2016. PMID 27812990
  4. The metabolic sensor AKIN10 modulates the Arabidopsis circadian clock in a light-dependent manner. Shin J, et al. Plant Cell Environ, 2017 Jul. PMID 28054361
  5. The AMP-Activated Protein Kinase KIN10 Is Involved in the Regulation of Autophagy in Arabidopsis. Chen L, et al. Front Plant Sci, 2017. PMID 28740502, Free PMC Article

See all (72) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Molecular mechanism of trehalose 6-phosphate inhibition of the plant metabolic sensor kinase SnRK1.
    Title: Molecular mechanism of trehalose 6-phosphate inhibition of the plant metabolic sensor kinase SnRK1.
  2. The evolutionarily conserved kinase SnRK1 orchestrates resource mobilization during Arabidopsis seedling establishment.
    Title: The evolutionarily conserved kinase SnRK1 orchestrates resource mobilization during Arabidopsis seedling establishment.
  3. Kinase SnRK1.1 regulates nitrate channel SLAH3 engaged in nitrate-dependent alleviation of ammonium toxicity.
    Title: Kinase SnRK1.1 regulates nitrate channel SLAH3 engaged in nitrate-dependent alleviation of ammonium toxicity.
  4. KIN10 promotes stomatal development through stabilization of the SPEECHLESS transcription factor.
    Title: KIN10 promotes stomatal development through stabilization of the SPEECHLESS transcription factor.
  5. SnRK1 mediates the phosphorylation and concomitant inhibition of AtCCT1.[SnRK1]
    Title: Arabidopsis CTP:phosphocholine cytidylyltransferase 1 is phosphorylated and inhibited by sucrose nonfermenting 1-related protein kinase 1 (SnRK1).
  6. SnRK1.1 is localized dynamically between the nucleus and endoplasmic reticulum (ER). ER-associated SnRK1.1 fraction might be sensing the cellular energy status, being a point of crosstalk with other ER stress regulatory pathways
    Title: Dual and dynamic intracellular localization of Arabidopsis thaliana SnRK1.1.
  7. the SnRK1-eIFiso4G1 relay controls the translation of an array of genes under hypoxia.
    Title: The SnRK1-eIFiso4G1 signaling relay regulates the translation of specific mRNAs in Arabidopsis under submergence.
  8. the role of AKIN10, on clock periodicity, is reported.
    Title: AKIN10 activity as a cellular link between metabolism and circadian-clock entrainment in Arabidopsis thaliana.
  9. KIN10 expression modulates root phenotype of Arabidopsis thaliana root system in condition of energy stress.
    Title: The influence of protein kinase KIN10 gene expression on root phenotype of Arabidopsis thaliana root system in condition of energy stress.
  10. KIN10 is required for sucrose-induced hypocotyl elongation in light/dark cycles.
    Title: The Energy-Signaling Hub SnRK1 Is Important for Sucrose-Induced Hypocotyl Elongation.
Submit: New GeneRIF Correction See all GeneRIFs (32)

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_001125074.2
NM_110974.5
NM_180157.1

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables kinase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables phosphatase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within abscisic acid-activated signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within detection of nutrient IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within developmental process involved in reproduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within leaf senescence IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in plant organ development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of abscisic acid-activated signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of autophagy IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within primary root development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of leaf senescence IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to glucose IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to herbicide IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to hypoxia IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to oxidative stress IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to salt IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in starch metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within sugar mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within vegetative phase change IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in vegetative to reproductive phase transition of meristem IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in chloroplast IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
part_of nuclear ubiquitin ligase complex IPI
Inferred from Physical Interaction
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
SNF1 kinase homolog 10
NP_001118546.1
  • SNF1 kinase homolog 10 (KIN10); FUNCTIONS IN: protein binding, protein serine/threonine kinase activity, protein kinase activity; INVOLVED IN: in 8 processes; LOCATED IN: nuclear ubiquitin ligase complex; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Ubiquitin-associated/translation elongation factor EF1B, N-terminal (InterPro:IPR000449), Kinase-associated KA1 (InterPro:IPR001772), Serine/threonine-protein kinase domain (InterPro:IPR002290), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271), Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote (InterPro:IPR015940), Protein kinase, Snf1-like AMPK (InterPro:IPR015741), Protein kinase, catalytic domain (InterPro:IPR000719), Calcium/calmodulin-dependent protein kinase-like (InterPro:IPR020636); BEST Arabidopsis thaliana protein match is: SNF1 kinase homolog 11 (TAIR:AT3G29160.2); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
NP_566130.1
  • SNF1 kinase homolog 10 (KIN10); FUNCTIONS IN: protein binding, protein serine/threonine kinase activity, protein kinase activity; INVOLVED IN: in 8 processes; LOCATED IN: nuclear ubiquitin ligase complex; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Ubiquitin-associated/translation elongation factor EF1B, N-terminal (InterPro:IPR000449), Kinase-associated KA1 (InterPro:IPR001772), Serine/threonine-protein kinase domain (InterPro:IPR002290), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271), Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote (InterPro:IPR015940), Protein kinase, Snf1-like AMPK (InterPro:IPR015741), Protein kinase, catalytic domain (InterPro:IPR000719), Calcium/calmodulin-dependent protein kinase-like (InterPro:IPR020636); BEST Arabidopsis thaliana protein match is: SNF1 kinase homolog 11 (TAIR:AT3G29160.2); Has 133405 Blast hits to 131080 proteins in 4728 species: Archae - 166; Bacteria - 15101; Metazoa - 49470; Fungi - 13387; Plants - 32551; Viruses - 541; Other Eukaryotes - 22189 (source: NCBI BLink).
NP_850488.1
  • SNF1 kinase homolog 10 (KIN10); FUNCTIONS IN: protein binding, protein serine/threonine kinase activity, protein kinase activity; INVOLVED IN: in 8 processes; LOCATED IN: nuclear ubiquitin ligase complex; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Ubiquitin-associated/translation elongation factor EF1B, N-terminal (InterPro:IPR000449), Protein kinase, ATP binding site (InterPro:IPR017441), Kinase-associated KA1 (InterPro:IPR001772), Serine/threonine-protein kinase domain (InterPro:IPR002290), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271), Protein kinase, Snf1-like AMPK (InterPro:IPR015741), Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote (InterPro:IPR015940), Protein kinase, catalytic domain (InterPro:IPR000719), Calcium/calmodulin-dependent protein kinase-like (InterPro:IPR020636), Tyrosine-protein kinase, catalytic domain (InterPro:IPR020635); BEST Arabidopsis thaliana protein match is: SNF1 kinase homolog 11 (TAIR:AT3G29160.2); Has 133590 Blast hits to 131265 proteins in 4759 species: Archae - 166; Bacteria - 15153; Metazoa - 49555; Fungi - 13420; Plants - 32561; Viruses - 542; Other Eukaryotes - 22193 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003074.8 Reference assembly

    Range
    31145..34670 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001125074.2 → NP_001118546.1  SNF1 kinase homolog 10 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001118546.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A6XGR0, O04728, Q38987, Q38997, Q39076, Q8RWD2
    UniProtKB/TrEMBL
    A0A178VFA5, A0A5S9X837, B9DFC1
    Conserved Domains (3) summary
    cd12122
    Location:388 → 509
    AMPKA_C; C-terminal regulatory domain of 5'-AMP-activated protein kinase (AMPK) alpha catalytic subunit
    cd14335
    Location:293 → 333
    UBA_SnRK1_plant; UBA domain found in the plant sucrose nonfermenting-1-related kinase (SnRK1) proteins
    cd14079
    Location:16 → 271
    STKc_AMPK_alpha; Catalytic domain of the Alpha subunit of the Serine/Threonine Kinase, AMP-activated protein kinase

  2. NM_110974.5 → NP_566130.1  SNF1 kinase homolog 10 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_566130.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A6XGR0, O04728, Q38987, Q38997, Q39076, Q8RWD2
    UniProtKB/TrEMBL
    A0A178VFA5, A0A5S9X837, B9DFC1
    Conserved Domains (3) summary
    cd12122
    Location:388 → 509
    AMPKA_C; C-terminal regulatory domain of 5'-AMP-activated protein kinase (AMPK) alpha catalytic subunit
    cd14335
    Location:293 → 333
    UBA_SnRK1_plant; UBA domain found in the plant sucrose nonfermenting-1-related kinase (SnRK1) proteins
    cd14079
    Location:16 → 271
    STKc_AMPK_alpha; Catalytic domain of the Alpha subunit of the Serine/Threonine Kinase, AMP-activated protein kinase

  3. NM_180157.1 → NP_850488.1  SNF1 kinase homolog 10 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_850488.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A5S9X837, B9DFC1
    Conserved Domains (3) summary
    cd12122
    Location:411 → 532
    AMPKA_C; C-terminal regulatory domain of 5'-AMP-activated protein kinase (AMPK) alpha catalytic subunit
    cd14335
    Location:316 → 356
    UBA_SnRK1_plant; UBA domain found in the plant sucrose nonfermenting-1-related kinase (SnRK1) proteins
    cd14079
    Location:39 → 294
    STKc_AMPK_alpha; Catalytic domain of the Alpha subunit of the Serine/Threonine Kinase, AMP-activated protein kinase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q38997.3

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