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FAD5 fatty acid desaturase 5 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 820828, updated on 18-Sep-2024

Summary

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Official Symbol
FAD5
Official Full Name
fatty acid desaturase 5
Primary source
TAIR:AT3G15850
Locus tag
AT3G15850
See related
Araport:AT3G15850
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ADS3; AtADS3; FADB; fatty acid desaturase 5; FATTY ACID DESATURASE B; JB67
Summary
Chloroplastic enzyme responsible for the synthesis of 16:1 fatty acids from galactolipids and sulpholipids. Uses ferredoxin as electron donor.
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Genomic context

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See FAD5 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
5
Sequence:
Chromosome: 3; NC_003074.8 (5358601..5361185)

Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene phosphatidic acid phosphatase-related / PAP2-like protein Neighboring gene post-illumination chlorophyll fluorescence increase Neighboring gene plant self-incompatibility protein S1 family protein Neighboring gene Fatty acid desaturase family protein Neighboring gene WUS-interacting protein 2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. FATTY ACID DESATURASE5 Is Required to Induce Autoimmune Responses in Gigantic Chloroplast Mutants of Arabidopsis. Li B, et al. Plant Cell, 2020 Oct. PMID 32796124, Free PMC Article
  2. A suppressor of fab1 challenges hypotheses on the role of thylakoid unsaturation in photosynthetic function. Barkan L, et al. Plant Physiol, 2006 Jul. PMID 16698898, Free PMC Article
  3. Identification of the Arabidopsis palmitoyl-monogalactosyldiacylglycerol delta7-desaturase gene FAD5, and effects of plastidial retargeting of Arabidopsis desaturases on the fad5 mutant phenotype. Heilmann I, et al. Plant Physiol, 2004 Dec. PMID 15579662, Free PMC Article
  4. Photoinhibition in mutants of Arabidopsis deficient in thylakoid unsaturation. Vijayan P, et al. Plant Physiol, 2002 Jun. PMID 12068126, Free PMC Article
  5. The impact of alteration of polyunsaturated fatty acid levels on C6-aldehyde formation of Arabidopsis thaliana leaves. Zhuang H, et al. Plant Physiol, 1996 Jul. PMID 8754681, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. FATTY ACID DESATURASE5 Is Required to Induce Autoimmune Responses in Gigantic Chloroplast Mutants of Arabidopsis.
    Title: FATTY ACID DESATURASE5 Is Required to Induce Autoimmune Responses in Gigantic Chloroplast Mutants of Arabidopsis.
  2. Nonsense mutation at this site affects activity of the plastidial palmitoyl-monogalactosyldiacylglycerol Delta7-desaturase FAD5.
    Title: Identification of the Arabidopsis palmitoyl-monogalactosyldiacylglycerol delta7-desaturase gene FAD5, and effects of plastidial retargeting of Arabidopsis desaturases on the fad5 mutant phenotype.
  3. The overall leaf fatty acid composition of S31 plants contained 31% 16:0 compared with 23% in fab1 and 17% in wild type. Biochemical and genetic analysis showed that S31 plants contain a new allele of fatty acid desaturation 5 (fad5), fad5-2.
    Title: A suppressor of fab1 challenges hypotheses on the role of thylakoid unsaturation in photosynthetic function.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

NM_112455.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables palmitoyl-[glycerolipid] 7-desaturase activity IEA
Inferred from Electronic Annotation
more info
  
enables palmitoyl-[glycerolipid] 7-desaturase activity IMP
Inferred from Mutant Phenotype
more info
  
Process Evidence Code Pubs
involved_in oxylipin biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within photoinhibition IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in unsaturated fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within unsaturated fatty acid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chloroplast ISM
Inferred from Sequence Model
more info
  
located_in thylakoid TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
fatty acid desaturase 5
NP_566529.1
  • fatty acid desaturase 5 (FAD5); CONTAINS InterPro DOMAIN/s: Fatty acid desaturase, type 1, core (InterPro:IPR015876), Fatty acid desaturase, type 1 (InterPro:IPR005804); BEST Arabidopsis thaliana protein match is: Fatty acid desaturase family protein (TAIR:AT3G15870.1); Has 3424 Blast hits to 3424 proteins in 822 species: Archae - 0; Bacteria - 1534; Metazoa - 801; Fungi - 236; Plants - 106; Viruses - 4; Other Eukaryotes - 743 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003074.8 Reference assembly

    Range
    5358601..5361185
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_112455.4 → NP_566529.1  fatty acid desaturase 5 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_566529.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8LCQ8, Q949X0, Q9LVZ4
    UniProtKB/TrEMBL
    A0A178VBZ6, A0A5S9XD27, A0A654F7K4, A0A7G2EQD3
    Conserved Domains (1) summary
    cl00615
    Location:96 → 369
    Membrane-FADS-like; The membrane fatty acid desaturase (Membrane_FADS)-like CD includes membrane FADSs, alkane hydroxylases, beta carotene ketolases (CrtW-like), hydroxylases (CrtR-like), and other related proteins. They are present in all groups of organisms with the ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q949X0.2

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