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FAB1B phosphatidylinositol-4-phosphate 5-kinase family protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 820647, updated on 18-Sep-2024

Summary

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Official Symbol
FAB1B
Official Full Name
phosphatidylinositol-4-phosphate 5-kinase family protein
Primary source
TAIR:AT3G14270
Locus tag
AT3G14270
See related
Araport:AT3G14270
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
FORMS APLOID AND BINUCLEATE CELLS 1B
Summary
Encodes a protein that is predicted to act as a 1-phosphatidylinositol-3-phosphate (PtdIns3P) 5-kinase based on its homology to Fab1 from yeast. It contains an FYVE domain required for binding to PtdIns3P-containing membranes in yeast, as well as a Cpn60_TCP1 homology domain plus a kinase domain. fab1a/fab1b pollen grains not viable and have defective vacuolar organization. FAB1A and FAB1B complement the enlarged vacuolar phenotype of the fission yeast ste12delta mutant.
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Genomic context

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See FAB1B in Genome Data Viewer
Location:
chromosome: 3
Exon count:
12
Sequence:
Chromosome: 3; NC_003074.8 (4753705..4761456)

Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene RING/U-box superfamily protein Neighboring gene LURP-one-like protein (DUF567) Neighboring gene LL-diaminopimelate aminotransferase Neighboring gene ncRNA Neighboring gene 20S proteasome alpha subunit E2

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterization of FAB1 phosphatidylinositol kinases in Arabidopsis pollen tube growth and fertilization. Serrazina S, et al. New Phytol, 2014 Aug. PMID 24807078
  2. Arabidopsis FAB1A/B is possibly involved in the recycling of auxin transporters. Hirano T, et al. Plant Signal Behav, 2011 Apr. PMID 21412048, Free PMC Article
  3. Loss-of-function and gain-of-function mutations in FAB1A/B impair endomembrane homeostasis, conferring pleiotropic developmental abnormalities in Arabidopsis. Hirano T, et al. Plant Physiol, 2011 Feb. PMID 21173023, Free PMC Article
  4. Arabidopsis FAB1/PIKfyve proteins are essential for development of viable pollen. Whitley P, et al. Plant Physiol, 2009 Dec. PMID 19846542, Free PMC Article
  5. Rapid structural changes and acidification of guard cell vacuoles during stomatal closure require phosphatidylinositol 3,5-bisphosphate. Bak G, et al. Plant Cell, 2013 Jun. PMID 23757398, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The function of the Arabidopsis genes encoding FAB1B and FAB1D, both highly expressed in pollen, were investigated.
    Title: Characterization of FAB1 phosphatidylinositol kinases in Arabidopsis pollen tube growth and fertilization.
  2. Data indicate that single and double mutants of phosphatidylinositol 3-phosphate 5-kinases (PI3P5Ks) FAB1A, FAB1B, FAB1C and FAB1D exhibited slow stomatal closure upon ABA treatment.
    Title: Rapid structural changes and acidification of guard cell vacuoles during stomatal closure require phosphatidylinositol 3,5-bisphosphate.
  3. Results suggest that impairment of the function of Arabidopsis FAB1A/B might cause a defect in the membrane recycling capabilities of the auxin transporters and inhibit proper auxin transport into the cells in Arabidopsis.
    Title: Arabidopsis FAB1A/B is possibly involved in the recycling of auxin transporters.
  4. Imbalanced expression of FAB1A/B impairs endomembrane homeostasis including endocytosis, vacuole formation, and vacuolar acidification.
    Title: Loss-of-function and gain-of-function mutations in FAB1A/B impair endomembrane homeostasis, conferring pleiotropic developmental abnormalities in Arabidopsis.
  5. Activity of FAB1 proteins is essential for the development of viable pollen. [FAB1B]
    Title: Arabidopsis FAB1/PIKfyve proteins are essential for development of viable pollen.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

NM_001338116.1

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables 1-phosphatidylinositol-3-phosphate 5-kinase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables 1-phosphatidylinositol-3-phosphate 5-kinase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables phosphatidylinositol binding ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within endomembrane system organization IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in phosphatidylinositol metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within pollen development IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
acts_upstream_of_or_within stomatal closure IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within vacuole organization IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISM
Inferred from Sequence Model
more info
  
located_in endosome IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion HDA PubMed 

General protein information

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Preferred Names
phosphatidylinositol-4-phosphate 5-kinase family protein
NP_001319548.1
  • FORMS APLOID AND BINUCLEATE CELLS 1B (FAB1B); CONTAINS InterPro DOMAIN/s: Chaperonin Cpn60/TCP-1 (InterPro:IPR002423), Zinc finger, FYVE-type (InterPro:IPR000306), Zinc finger, FYVE-related (InterPro:IPR017455), Zinc finger, FYVE/PHD-type (InterPro:IPR011011), Phosphatidylinositol-4-phosphate 5-kinase, core (InterPro:IPR002498); BEST Arabidopsis thaliana protein match is: 1-phosphatidylinositol-4-phosphate 5-kinases;zinc ion binding;1-phosphatidylinositol-3-phosphate 5-kinases (TAIR:AT4G33240.2); Has 8765 Blast hits to 8134 proteins in 458 species: Archae - 587; Bacteria - 13; Metazoa - 3836; Fungi - 1744; Plants - 978; Viruses - 3; Other Eukaryotes - 1604 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003074.8 Reference assembly

    Range
    4753705..4761456
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_112285.4 → NP_188044.1  phosphatidylinositol-4-phosphate 5-kinase family protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_188044.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q0WPY8, Q9LUM0
    UniProtKB/TrEMBL
    A0A5S9XC86, A0A654F727
    Conserved Domains (3) summary
    cd03334
    Location:386 → 658
    Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...
    cl28890
    Location:35 → 102
    FYVE_like_SF; FYVE domain like superfamily
    cd17300
    Location:1495 → 1758
    PIPKc_PIKfyve; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain found in 1-phosphatidylinositol-3-phosphate 5-kinase and similar proteins

  2. NM_001338116.1 → NP_001319548.1  phosphatidylinositol-4-phosphate 5-kinase family protein [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q0WPY8, Q9LUM0
    UniProtKB/TrEMBL
    A0A5S9XC86, A0A654F727
    Conserved Domains (3) summary
    cd03334
    Location:386 → 658
    Fab1_TCP; TCP-1 like domain of the eukaryotic phosphatidylinositol 3-phosphate (PtdIns3P) 5-kinase Fab1. Fab1p is important for vacuole size regulation, presumably by modulating PtdIns(3,5)P2 effector activity. In the human homolog p235/PIKfyve deletion of this ...
    cl28890
    Location:35 → 102
    FYVE_like_SF; FYVE domain like superfamily
    cd17300
    Location:1495 → 1758
    PIPKc_PIKfyve; Phosphatidylinositol phosphate kinase (PIPK) catalytic domain found in 1-phosphatidylinositol-3-phosphate 5-kinase and similar proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9LUM0.1

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