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PAH1 Lipin family protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 820113, updated on 18-Sep-2024

Summary

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Official Symbol
PAH1
Official Full Name
Lipin family protein
Primary source
TAIR:AT3G09560
Locus tag
AT3G09560
See related
Araport:AT3G09560
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ATPAH1; PHOSPHATIDIC ACID PHOSPHOHYDROLASE 1
Summary
The PAH1 gene encodes a phosphatidate phosphohydrolase. Mutant analysis revealed its involvement in galactolipid synthesis pathway, and the membrane lipid remodeling. The pah1pah2 double-mutant showed enhanced Al-susceptibility under low-P conditions, but there was no significant differences in Al tolerance between pah1pah2 and wild type when they were grown in a solution containing 35 muM Pi.
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Genomic context

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See PAH1 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
11
Sequence:
Chromosome: 3; NC_003074.8 (2934592..2939511, complement)

Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene exocyst subunit exo70 family protein H3 Neighboring gene Pectin lyase-like superfamily protein Neighboring gene Ankyrin repeat family protein Neighboring gene Lung seven transmembrane receptor family protein Neighboring gene FAD/NAD(P)-binding oxidoreductase family protein Neighboring gene tRNA-Ser

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The rice RMR1 associates with a distinct prevacuolar compartment for the protein storage vacuole pathway. Shen Y, et al. Mol Plant, 2011 Sep. PMID 21493745
  2. Phosphatidic acid phosphohydrolase 1 and 2 regulate phospholipid synthesis at the endoplasmic reticulum in Arabidopsis. Eastmond PJ, et al. Plant Cell, 2010 Aug. PMID 20699392, Free PMC Article
  3. Arabidopsis lipins mediate eukaryotic pathway of lipid metabolism and cope critically with phosphate starvation. Nakamura Y, et al. Proc Natl Acad Sci U S A, 2009 Dec 8. PMID 19923426, Free PMC Article
  4. Cyclin-dependent kinase activity enhances phosphatidylcholine biosynthesis in Arabidopsis by repressing phosphatidic acid phosphohydrolase activity. Craddock CP, et al. Plant J, 2017 Jan. PMID 27595588, Free PMC Article
  5. Deciphering the roles of Arabidopsis LPCAT and PAH in phosphatidylcholine homeostasis and pathway coordination for chloroplast lipid synthesis. Wang L, et al. Plant J, 2014 Dec. PMID 25268378

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that phosphatidylcholine (PC) biosynthesis is repressed by disruption of the core cell cycle regulator CYCLIN-DEPENDENT KINASE A;1 (CDKA;1) and that this repression is reliant on PHOSPHATIDIC ACID PHOSPHOHYDROLASE (PAH).
    Title: Cyclin-dependent kinase activity enhances phosphatidylcholine biosynthesis in Arabidopsis by repressing phosphatidic acid phosphohydrolase activity.
  2. PAH1 and PAH2 function indirectly as repressors of phospholipid biosynthesis.
    Title: Phosphatidic acid phosphohydrolase 1 and 2 regulate phospholipid synthesis at the endoplasmic reticulum in Arabidopsis.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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NM_001125132.1
NM_001337827.1
NM_111790.4
NM_202539.2

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables phosphatidate phosphatase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidate phosphatase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to phosphate starvation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within galactolipid biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in intracellular protein transport IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within lipid metabolic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within phospholipid biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  
located_in protein storage vacuole membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Lipin family protein
NP_001118604.1
  • Lipin family protein; FUNCTIONS IN: phosphatidate phosphatase activity; INVOLVED IN: cellular response to phosphate starvation, lipid metabolic process; LOCATED IN: cellular_component unknown; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: LNS2, Lipin/Ned1/Smp2 (InterPro:IPR013209), Lipin, N-terminal conserved region (InterPro:IPR007651); BEST Arabidopsis thaliana protein match is: phosphatidic acid phosphohydrolase 2 (TAIR:AT5G42870.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
NP_187567.1
  • PHOSPHATIDIC ACID PHOSPHOHYDROLASE 1 (PAH1); CONTAINS InterPro DOMAIN/s: LNS2, Lipin/Ned1/Smp2 (InterPro:IPR013209), Lipin, N-terminal conserved region (InterPro:IPR007651); BEST Arabidopsis thaliana protein match is: phosphatidic acid phosphohydrolase 2 (TAIR:AT5G42870.1); Has 5210 Blast hits to 3195 proteins in 460 species: Archae - 22; Bacteria - 1897; Metazoa - 1353; Fungi - 717; Plants - 207; Viruses - 16; Other Eukaryotes - 998 (source: NCBI BLink).
NP_974268.1
  • Lipin family protein; CONTAINS InterPro DOMAIN/s: LNS2, Lipin/Ned1/Smp2 (InterPro:IPR013209), Lipin, N-terminal conserved region (InterPro:IPR007651); BEST Arabidopsis thaliana protein match is: phosphatidic acid phosphohydrolase 2 (TAIR:AT5G42870.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003074.8 Reference assembly

    Range
    2934592..2939511 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_202539.2 → NP_974268.1  Lipin family protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_974268.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D8L210, Q0WNF2, Q9SF47
    UniProtKB/TrEMBL
    A0A654F5I6
    Conserved Domains (3) summary
    pfam04571
    Location:1 → 105
    Lipin_N; lipin, N-terminal conserved region
    pfam08235
    Location:655 → 880
    LNS2; LNS2 (Lipin/Ned1/Smp2)
    pfam16876
    Location:492 → 598
    Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain

  2. NM_111790.4 → NP_187567.1  Lipin family protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_187567.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D8L210, Q0WNF2, Q9SF47
    UniProtKB/TrEMBL
    A0A654F5I6
    Conserved Domains (3) summary
    pfam04571
    Location:1 → 105
    Lipin_N; lipin, N-terminal conserved region
    pfam08235
    Location:655 → 880
    LNS2; LNS2 (Lipin/Ned1/Smp2)
    pfam16876
    Location:492 → 598
    Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain

  3. NM_001337827.1 → NP_001326239.1  Lipin family protein [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D8L210, Q0WNF2, Q9SF47
    UniProtKB/TrEMBL
    A0A654F5I6
    Conserved Domains (3) summary
    pfam04571
    Location:1 → 105
    Lipin_N; lipin, N-terminal conserved region
    pfam08235
    Location:655 → 880
    LNS2; LNS2 (Lipin/Ned1/Smp2)
    pfam16876
    Location:492 → 598
    Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain

  4. NM_001125132.1 → NP_001118604.1  Lipin family protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001118604.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D8L210, Q0WNF2, Q9SF47
    UniProtKB/TrEMBL
    A0A654F5I6
    Conserved Domains (3) summary
    pfam04571
    Location:1 → 105
    Lipin_N; lipin, N-terminal conserved region
    pfam08235
    Location:655 → 880
    LNS2; LNS2 (Lipin/Ned1/Smp2)
    pfam16876
    Location:492 → 598
    Lipin_mid; Lipin/Ned1/Smp2 multi-domain protein middle domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9SF47.1

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