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PLC2 phospholipase C 2 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 819999, updated on 18-Sep-2024

Summary

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Official Symbol
PLC2
Official Full Name
phospholipase C 2
Primary source
TAIR:AT3G08510
Locus tag
AT3G08510
See related
Araport:AT3G08510
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ATPLC2; phospholipase C 2
Summary
Phosphoinositide-specific phospholipase C (PI-PLC), catalyzes hydrolysis of phosphatidylinositol 4,5-bisphosphate into inositol 1,4,5-trisphosphate and diacylglycerol.
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Genomic context

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See PLC2 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
9
Sequence:
Chromosome: 3; NC_003074.8 (2582362..2585898, complement)

Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene miscRNA Neighboring gene zinc finger (CCCH-type/C3HC4-type RING finger) family protein Neighboring gene Ribosomal protein L41 family Neighboring gene Clathrin, heavy chain

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Arabidopsis phosphatidylinositol-phospholipase C2 (PLC2) is required for female gametogenesis and embryo development. Di Fino LM, et al. Planta, 2017 Apr. PMID 27999988
  2. Arabidopsis AtPLC2 Is a Primary Phosphoinositide-Specific Phospholipase C in Phosphoinositide Metabolism and the Endoplasmic Reticulum Stress Response. Kanehara K, et al. PLoS Genet, 2015 Sep. PMID 26401841, Free PMC Article
  3. Arabidopsis PLC2 is involved in auxin-modulated reproductive development. Li L, et al. Plant J, 2015 Nov. PMID 26340337
  4. AtPLC2, a gene encoding phosphoinositide-specific phospholipase C, is constitutively expressed in vegetative and floral tissues in Arabidopsis thaliana. Hirayama T, et al. Plant Mol Biol, 1997 May. PMID 9177324
  5. Phosphatidylinositol-specific phospholipase C2 functions in auxin-modulated root development. Chen X, et al. Plant Cell Environ, 2019 May. PMID 30496625

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These results demonstrate a critical role of PLC2 in auxin-mediated root development in Arabidopsis, in which PLC2 influences the polar distribution of PIN2.
    Title: Phosphatidylinositol-specific phospholipase C2 functions in auxin-modulated root development.
  2. The generation of reactive oxygen species (ROS) upon flg22 treatment is compromised in the PLC2-defficient plants, suggesting an effect of PLC2 in a branch of MAMP-triggered immunity and nonhost resistance that involves early ROS-regulated processes. Consistently, PLC2 associates with the NADPH oxidase RBOHD, suggesting its potential regulation by PLC2.
    Title: Phospholipase C2 Affects MAMP-Triggered Immunity by Modulating ROS Production.
  3. essential for female gametogenesis and embryo development
    Title: Arabidopsis phosphatidylinositol-phospholipase C2 (PLC2) is required for female gametogenesis and embryo development.
  4. PLC2 is involved in auxin biosynthesis and signaling, thus modulating development of both male and female gametophytes in Arabidopsis.
    Title: Arabidopsis PLC2 is involved in auxin-modulated reproductive development.
  5. seedlings of plc2-1 mutant showed growth defect that was complemented by heterologous expression of AtPLC2, suggesting that phosphoinositide-specific phospholipase C activity borne by AtPLC2 is required for seedling growth
    Title: Arabidopsis AtPLC2 Is a Primary Phosphoinositide-Specific Phospholipase C in Phosphoinositide Metabolism and the Endoplasmic Reticulum Stress Response.
  6. AtPI4KIIIbeta1 and AtPI4KIIIbeta2 can both act upstream of the PI-PLC. There is evidence for the occurrence of a de novo synthesis of PtdIns4P by PI4K that coincides with PI-PLC activation. [PI-PLC]
    Title: Arabidopsis type-III phosphatidylinositol 4-kinases β1 and β2 are upstream of the phospholipase C pathway triggered by cold exposure.
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Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_001035583.1
NM_001161124.1
NM_001337760.1
NM_111686.6

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables phosphatidylinositol phospholipase C activity IEA
Inferred from Electronic Annotation
more info
  
enables phospholipase C activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phospholipase C activity TAS
Traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within defense response to bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within embryo sac development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within floral organ development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within microsporogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of auxin biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in plasma membrane HDA PubMed 

General protein information

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Preferred Names
phospholipase C 2
NP_001030660.1
  • phospholipase C 2 (PLC2); FUNCTIONS IN: phospholipase C activity; INVOLVED IN: signal transduction, intracellular signaling pathway, lipid metabolic process; LOCATED IN: plasma membrane; EXPRESSED IN: 27 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Phospholipase C, phosphoinositol-specific, EF-hand-like (InterPro:IPR015359), Phospholipase C, phosphatidylinositol-specific, X domain (InterPro:IPR000909), C2 calcium/lipid-binding domain, CaLB (InterPro:IPR008973), Phospholipase C, phosphoinositol-specific (InterPro:IPR001192), Phospholipase C, phosphatidylinositol-specific, Y domain (InterPro:IPR001711), PLC-like phosphodiesterase, TIM beta/alpha-barrel domain (InterPro:IPR017946), C2 membrane targeting protein (InterPro:IPR018029), C2 calcium-dependent membrane targeting (InterPro:IPR000008); BEST Arabidopsis thaliana protein match is: Phosphoinositide-specific phospholipase C family protein (TAIR:AT3G55940.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
NP_001154596.1
  • phospholipase C 2; FUNCTIONS IN: phospholipase C activity; INVOLVED IN: signal transduction, intracellular signaling pathway, lipid metabolic process; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Phospholipase C, phosphoinositol-specific, EF-hand-like (InterPro:IPR015359), Phospholipase C, phosphatidylinositol-specific, X domain (InterPro:IPR000909), C2 calcium/lipid-binding domain, CaLB (InterPro:IPR008973), Phospholipase C, phosphoinositol-specific (InterPro:IPR001192), Phospholipase C, phosphatidylinositol-specific, Y domain (InterPro:IPR001711), PLC-like phosphodiesterase, TIM beta/alpha-barrel domain (InterPro:IPR017946), C2 membrane targeting protein (InterPro:IPR018029), C2 calcium-dependent membrane targeting (InterPro:IPR000008); BEST Arabidopsis thaliana protein match is: Phosphoinositide-specific phospholipase C family protein (TAIR:AT3G55940.1); Has 2455 Blast hits to 1965 proteins in 253 species: Archae - 0; Bacteria - 0; Metazoa - 1631; Fungi - 365; Plants - 250; Viruses - 0; Other Eukaryotes - 209 (source: NCBI BLink).
NP_187464.1
  • phospholipase C 2 (PLC2); FUNCTIONS IN: phospholipase C activity; INVOLVED IN: signal transduction, intracellular signaling pathway, lipid metabolic process; LOCATED IN: plasma membrane; EXPRESSED IN: 27 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Phospholipase C, phosphoinositol-specific, EF-hand-like (InterPro:IPR015359), Phospholipase C, phosphatidylinositol-specific, X domain (InterPro:IPR000909), PLC-like phosphodiesterase, TIM beta/alpha-barrel domain (InterPro:IPR017946), C2 membrane targeting protein (InterPro:IPR018029), C2 calcium/lipid-binding domain, CaLB (InterPro:IPR008973), Phospholipase C, phosphoinositol-specific (InterPro:IPR001192), C2 calcium-dependent membrane targeting (InterPro:IPR000008), Phospholipase C, phosphatidylinositol-specific, Y domain (InterPro:IPR001711); BEST Arabidopsis thaliana protein match is: Phosphoinositide-specific phospholipase C family protein (TAIR:AT3G55940.1); Has 2471 Blast hits to 1979 proteins in 261 species: Archae - 0; Bacteria - 0; Metazoa - 1631; Fungi - 374; Plants - 251; Viruses - 0; Other Eukaryotes - 215 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003074.8 Reference assembly

    Range
    2582362..2585898 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_111686.6 → NP_187464.1  phospholipase C 2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_187464.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q39033, Q56XL3, Q8LG47
    UniProtKB/TrEMBL
    A0A178VDK7, A0A384L124, A0A5S9XAG6, C0Z2P3
    Conserved Domains (1) summary
    PLN02222
    Location:1 → 581
    PLN02222; phosphoinositide phospholipase C 2

  2. NM_001337760.1 → NP_001327169.1  phospholipase C 2 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A5S9XAG6, F4IX90

  3. NM_001161124.1 → NP_001154596.1  phospholipase C 2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001154596.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A5S9XAG6, F4IX90
    Conserved Domains (4) summary
    cd00275
    Location:431 → 551
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    PLN02222
    Location:1 → 552
    PLN02222; phosphoinositide phospholipase C 2
    pfam09279
    Location:26 → 102
    EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    cl14615
    Location:102 → 420
    PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily

  4. NM_001035583.1 → NP_001030660.1  phospholipase C 2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001030660.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q39033, Q56XL3, Q8LG47
    UniProtKB/TrEMBL
    A0A178VDK7, A0A384L124, A0A5S9XAG6, C0Z2P3
    Conserved Domains (1) summary
    PLN02222
    Location:1 → 581
    PLN02222; phosphoinositide phospholipase C 2
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q39033.1

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