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ACBP4 acyl-CoA binding protein 4 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 819707, updated on 18-Sep-2024

Summary

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Official Symbol
ACBP4
Official Full Name
acyl-CoA binding protein 4
Primary source
TAIR:AT3G05420
Locus tag
AT3G05420
See related
Araport:AT3G05420
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
acyl-CoA binding protein 4; AtACBP4; F22F7.13; F22F7_13
Summary
Acyl-CoA binding protein with high affinity for oleoyl-CoA. Expressed in all plant organs. Involved in fatty acid transport.
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Genomic context

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See ACBP4 in Genome Data Viewer
Location:
chromosome: 3
Exon count:
18
Sequence:
Chromosome: 3; NC_003074.8 (1561671..1567336)

Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene Major facilitator superfamily protein Neighboring gene Photosystem II reaction center PsbP family protein Neighboring gene pseudo Neighboring gene uncharacterized protein Neighboring gene Tudor/PWWP/MBT superfamily protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Kelch-motif containing acyl-CoA binding proteins AtACBP4 and AtACBP5 are differentially expressed and function in floral lipid metabolism. Ye ZW, et al. Plant Mol Biol, 2017 Jan. PMID 27826761
  2. Expression of Arabidopsis acyl-CoA-binding proteins AtACBP1 and AtACBP4 confers Pb(II) accumulation in Brassica juncea roots. DU ZY, et al. Plant Cell Environ, 2015 Jan. PMID 24906022
  3. Light-regulated Arabidopsis ACBP4 and ACBP5 encode cytosolic acyl-CoA-binding proteins that bind phosphatidylcholine and oleoyl-CoA ester. Xiao S, et al. Plant Physiol Biochem, 2009 Oct. PMID 19589686
  4. Ethylene- and pathogen-inducible Arabidopsis acyl-CoA-binding protein 4 interacts with an ethylene-responsive element binding protein. Li HY, et al. J Exp Bot, 2008. PMID 18836139, Free PMC Article
  5. Arabidopsis acyl-CoA-binding proteins ACBP4 and ACBP5 are subcellularly localized to the cytosol and ACBP4 depletion affects membrane lipid composition. Xiao S, et al. Plant Mol Biol, 2008 Dec. PMID 18773301, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ACBP4-WRKY70-RAP2.12 module positively regulates submergence-induced hypoxia response in Arabidopsis thaliana.
    Title: ACBP4-WRKY70-RAP2.12 module positively regulates submergence-induced hypoxia response in Arabidopsis thaliana.
  2. AtACBP4 and AtACBP5 both function in floral lipidic metabolism and play complementary roles in Arabidopsis microspore-to-pollen development.
    Title: Kelch-motif containing acyl-CoA binding proteins AtACBP4 and AtACBP5 are differentially expressed and function in floral lipid metabolism.
  3. The roles of cytosolic AtACBP4, 5 and 6 in floral development were addressed in this study.
    Title: The Arabidopsis cytosolic Acyl-CoA-binding proteins play combinatory roles in pollen development.
  4. AtACBP1 and AtACBP4 can protect lipids against Pb(II)-induced lipid peroxidation.
    Title: Expression of Arabidopsis acyl-CoA-binding proteins AtACBP1 and AtACBP4 confers Pb(II) accumulation in Brassica juncea roots.
  5. Data indicate that the acyl-CoA-binding proteins acbp4acbp5acbp6 mutant showed the lightest seed weight and highest sensitivity to abscisic acid during germination.
    Title: Arabidopsis cytosolic acyl-CoA-binding proteins ACBP4, ACBP5 and ACBP6 have overlapping but distinct roles in seed development.
  6. Data suggest that light-regulated ACBP4 and ACBP5 are potential candidates for the intracellular transport of oleoyl-CoA ester exported from the chloroplast to the endoplasmic reticulum for the biosynthesis of non-plastidial membrane lipids.
    Title: Light-regulated Arabidopsis ACBP4 and ACBP5 encode cytosolic acyl-CoA-binding proteins that bind phosphatidylcholine and oleoyl-CoA ester.
  7. ACBP4 and ACBP5 are available in the cytosol to bind and transfer cytosolic oleoyl-CoA esters
    Title: Arabidopsis acyl-CoA-binding proteins ACBP4 and ACBP5 are subcellularly localized to the cytosol and ACBP4 depletion affects membrane lipid composition.
  8. Interaction of acyl-CoA-binding protein 4 with the ethylene-responsive element binding protein is induced by ethylene.
    Title: Ethylene- and pathogen-inducible Arabidopsis acyl-CoA-binding protein 4 interacts with an ethylene-responsive element binding protein.
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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_111415.5
NM_202498.2

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables fatty-acyl-CoA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within lipid transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to ethylene IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to jasmonic acid IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to light stimulus TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytosol HDA PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
colocalizes_with nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
acyl-CoA binding protein 4
NP_187193.3
  • acyl-CoA binding protein 4 (ACBP4); FUNCTIONS IN: acyl-CoA binding; INVOLVED IN: lipid transport; LOCATED IN: cytosol, nucleus; EXPRESSED IN: 27 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Galactose oxidase/kelch, beta-propeller (InterPro:IPR011043), Kelch repeat type 2 (InterPro:IPR011498), Acyl-CoA-binding protein, ACBP (InterPro:IPR000582), Kelch-type beta propeller (InterPro:IPR015915), FERM/acyl-CoA-binding protein, 3-helical bundle (InterPro:IPR014352); BEST Arabidopsis thaliana protein match is: acyl-CoA binding protein 5 (TAIR:AT5G27630.1); Has 12542 Blast hits to 6987 proteins in 469 species: Archae - 21; Bacteria - 614; Metazoa - 5387; Fungi - 1265; Plants - 2730; Viruses - 3; Other Eukaryotes - 2522 (source: NCBI BLink).
NP_974227.1
  • acyl-CoA binding protein 4 (ACBP4); FUNCTIONS IN: acyl-CoA binding; INVOLVED IN: lipid transport; LOCATED IN: cytosol, nucleus; EXPRESSED IN: 27 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Galactose oxidase/kelch, beta-propeller (InterPro:IPR011043), Kelch repeat type 2 (InterPro:IPR011498), Acyl-CoA-binding protein, ACBP (InterPro:IPR000582), Kelch-type beta propeller (InterPro:IPR015915), FERM/acyl-CoA-binding protein, 3-helical bundle (InterPro:IPR014352); BEST Arabidopsis thaliana protein match is: acyl-CoA binding protein 5 (TAIR:AT5G27630.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003074.8 Reference assembly

    Range
    1561671..1567336
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_202498.2 → NP_974227.1  acyl-CoA binding protein 4 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_974227.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A654F5I3
    Conserved Domains (8) summary
    PLN02153
    Location:171 → 416
    PLN02153; epithiospecifier protein
    sd00038
    Location:185 → 241
    Kelch; KELCH repeat [structural motif]
    pfam00887
    Location:14 → 99
    ACBP; Acyl CoA binding protein
    pfam01344
    Location:184 → 225
    Kelch_1; Kelch motif
    pfam09304
    Location:552 → 639
    Cortex-I_coil; Cortexillin I, coiled coil
    pfam13415
    Location:305 → 355
    Kelch_3; Galactose oxidase, central domain
    pfam13854
    Location:395 → 432
    Kelch_5; Kelch motif
    pfam13964
    Location:244 → 296
    Kelch_6; Kelch motif

  2. NM_111415.5 → NP_187193.3  acyl-CoA binding protein 4 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_187193.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q3E7F2, Q9MA55
    UniProtKB/TrEMBL
    A0A178VCA4, A0A654F5I3, A0A7G2EG26
    Conserved Domains (4) summary
    PLN02153
    Location:170 → 415
    PLN02153; epithiospecifier protein
    sd00038
    Location:184 → 240
    Kelch; KELCH repeat [structural motif]
    pfam00887
    Location:14 → 99
    ACBP; Acyl CoA binding protein
    pfam01576
    Location:543 → 640
    Myosin_tail_1; Myosin tail
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9MA55.1

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