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LACS1 AMP-dependent synthetase and ligase family protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 819337, updated on 18-Sep-2024

Summary

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Official Symbol
LACS1
Official Full Name
AMP-dependent synthetase and ligase family protein
Primary source
TAIR:AT2G47240
Locus tag
AT2G47240
See related
Araport:AT2G47240
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
CER8; ECERIFERUM 8; LONG-CHAIN ACYL-COA SYNTHASE 1; T8I13.8
Summary
Encodes an acyl-CoA synthetase that acts on long-chain and very-long-chain fatty acids, involved in cuticular wax and cutin biosynthesis
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Genomic context

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See LACS1 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
19
Sequence:
Chromosome: 2; NC_003071.7 (19392497..19397907)

Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene polyribonucleotide phosphorylase, putative (DOMAIN OF UNKNOWN FUNCTION 724 5) Neighboring gene agenet domain protein (DOMAIN OF UNKNOWN FUNCTION 724 6) Neighboring gene long chain acyl-CoA synthetase Neighboring gene RNA helicase family protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Combined activity of LACS1 and LACS4 is required for proper pollen coat formation in Arabidopsis. Jessen D, et al. Plant J, 2011 Nov. PMID 21790813
  2. Organ fusion and defective cuticle function in a lacs1 lacs2 double mutant of Arabidopsis. Weng H, et al. Planta, 2010 Apr. PMID 20237894
  3. Arabidopsis CER8 encodes LONG-CHAIN ACYL-COA SYNTHETASE 1 (LACS1) that has overlapping functions with LACS2 in plant wax and cutin synthesis. Lü S, et al. Plant J, 2009 Aug. PMID 19392700
  4. Leaf Epicuticular Waxes of the Eceriferum Mutants in Arabidopsis. Jenks MA, et al. Plant Physiol, 1995 May. PMID 12228482, Free PMC Article
  5. Insertional mutant analysis reveals that long-chain acyl-CoA synthetase 1 (LACS1), but not LACS8, functionally overlaps with LACS9 in Arabidopsis seed oil biosynthesis. Zhao L, et al. Plant J, 2010 Dec. PMID 21143684

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The combined inactivation of LACS1 and LACS4 in Arabidopsis resulted in conditional pollen sterility and impaired wax biosynthesis.
    Title: Combined activity of LACS1 and LACS4 is required for proper pollen coat formation in Arabidopsis.
  2. LACS1 is localized in the ER and functionally overlaps with LACS9 to supply acyl-CoAs for TAG biosynthesis.
    Title: Insertional mutant analysis reveals that long-chain acyl-CoA synthetase 1 (LACS1), but not LACS8, functionally overlaps with LACS9 in Arabidopsis seed oil biosynthesis.
  3. lacs1 lacs2 double-mutant plants displayed pleiotropic phenotypes including organ fusion, abnormal flower development and reduced seed set.
    Title: Organ fusion and defective cuticle function in a lacs1 lacs2 double mutant of Arabidopsis.
  4. LACS1 is a functionally novel acyl-CoA synthetase that preferentially modifies both VLCFAs for wax synthesis and long-chain (C16) fatty acids for cutin synthesis.
    Title: Arabidopsis CER8 encodes LONG-CHAIN ACYL-COA SYNTHETASE 1 (LACS1) that has overlapping functions with LACS2 in plant wax and cutin synthesis.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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NM_001036477.1
NM_001337254.1
NM_001337255.1
NM_130292.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables long-chain fatty acid-CoA ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables very long-chain fatty acid-CoA ligase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cutin biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in fatty acid metabolic process TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within wax biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
AMP-dependent synthetase and ligase family protein
NP_001318440.1
  • LONG-CHAIN ACYL-COA SYNTHASE 1 (LACS1); FUNCTIONS IN: long-chain fatty acid-CoA ligase activity, very long-chain fatty acid-CoA ligase activity; INVOLVED IN: fatty acid biosynthetic process, cutin biosynthetic process, wax biosynthetic process; LOCATED IN: cellular_component unknown; EXPRESSED IN: 29 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: AMP-binding, conserved site (InterPro:IPR020845), AMP-dependent synthetase/ligase (InterPro:IPR000873); BEST Arabidopsis thaliana protein match is: AMP-dependent synthetase and ligase family protein (TAIR:AT4G23850.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
NP_182246.1
  • LONG-CHAIN ACYL-COA SYNTHASE 1 (LACS1); FUNCTIONS IN: long-chain fatty acid-CoA ligase activity, very long-chain fatty acid-CoA ligase activity; INVOLVED IN: fatty acid biosynthetic process, cutin biosynthetic process, wax biosynthetic process; LOCATED IN: cellular_component unknown; EXPRESSED IN: 29 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: AMP-binding, conserved site (InterPro:IPR020845), AMP-dependent synthetase/ligase (InterPro:IPR000873); BEST Arabidopsis thaliana protein match is: AMP-dependent synthetase and ligase family protein (TAIR:AT4G23850.1); Has 55133 Blast hits to 51773 proteins in 3295 species: Archae - 1024; Bacteria - 35525; Metazoa - 2495; Fungi - 1959; Plants - 1853; Viruses - 1; Other Eukaryotes - 12276 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003071.7 Reference assembly

    Range
    19392497..19397907
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_130292.4 → NP_182246.1  AMP-dependent synthetase and ligase family protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_182246.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O22898, Q56WP3, Q56ZG8
    UniProtKB/TrEMBL
    A0A5S9X7R0
    Conserved Domains (2) summary
    PLN02430
    Location:1 → 660
    PLN02430; long-chain-fatty-acid-CoA ligase
    cd05927
    Location:72 → 652
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

  2. NM_001337254.1 → NP_001318440.1  AMP-dependent synthetase and ligase family protein [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O22898, Q56WP3, Q56ZG8
    UniProtKB/TrEMBL
    A0A5S9X7R0

  3. NM_001036477.1 → NP_001031554.1  AMP-dependent synthetase and ligase family protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001031554.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O22898, Q56WP3, Q56ZG8
    UniProtKB/TrEMBL
    A0A5S9X7R0
    Conserved Domains (2) summary
    PLN02430
    Location:1 → 660
    PLN02430; long-chain-fatty-acid-CoA ligase
    cd05927
    Location:72 → 652
    LC-FACS_euk; Eukaryotic long-chain fatty acid CoA synthetase (LC-FACS)

  4. NM_001337255.1 → NP_001325159.1  AMP-dependent synthetase and ligase family protein [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178VU16, A0A1P8B2B8, A0A5S9X7R0
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O22898.1

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