POL Protein phosphatase 2C family protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: POL
Official Full Name: Protein phosphatase 2C family protein
Primary source: TAIR:AT2G46920
Locus tag: AT2G46920
See related: Araport:AT2G46920
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: F14M4.25; poltergeist
Summary: Pol mutations are recessive suppressors of meristem defects in strong clv1 and clv3 mutants, and nearly complete suppressors of weak clv1 mutants. Single mutants appear normal. Acts downstream of the CLV signaling pathway in meristem development and is required together with PLL1 for stem-cell maintenance through the regulation of WUS.
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Genomic context

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See POL in Genome Data Viewer

Location:: chromosome: 2

Exon count:: 5

Sequence:: Chromosome: 2; NC_003071.7 (19277884..19281811, complement)

Chromosome 2 - NC_003071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

POL and PLL1 localize to the plasma membrane in a myristoylation- and palmitoylation- dependent manner, and these acyl modifications are required for proper POL/PLL1 function.
Title: The role of the acyl modification, palmitoylation, in Arabidopsis stem cell regulation.
POL and PLL1 are phospholipid binding plasma membrane proteins.
Title: The Arabidopsis stem cell factor POLTERGEIST is membrane localized and phospholipid stimulated.
Key divisions in the early Arabidopsis embryo require POL and PLL1 phosphatases to establish the root stem cell organizer and vascular axis.
Title: Key divisions in the early Arabidopsis embryo require POL and PLL1 phosphatases to establish the root stem cell organizer and vascular axis.
POL and PLL1 are central players in regulating the balance between stem-cell maintenance and differentiation, and are the closest known factors to WUS regulation in the shoot meristem.
Title: POL and PLL1 phosphatases are CLAVATA1 signaling intermediates required for Arabidopsis shoot and floral stem cells.

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General gene information

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Homology

Orthologs from OrthoDB

NM_001337223.1

Supported by ESTs:

NM_001337224.1

Supported by ESTs:

NM_180132.3

Supported by ESTs:

NM_180133.2

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables myosin phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phospholipid binding	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine phosphatase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within maintenance of meristem identity	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of meristem structural organization	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	ISM Inferred from Sequence Model more info
located_in nucleus	NAS Non-traceable Author Statement more info
located_in plasma membrane	HDA more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: Protein phosphatase 2C family protein

NP_850463.1

poltergeist (POL); FUNCTIONS IN: phospholipid binding, protein serine/threonine phosphatase activity; INVOLVED IN: in 6 processes; LOCATED IN: nucleus, plasma membrane; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Protein phosphatase 2C-related (InterPro:IPR001932), Protein phosphatase 2C (InterPro:IPR015655), Protein phosphatase 2C, N-terminal (InterPro:IPR014045); BEST Arabidopsis thaliana protein match is: poltergeist like 1 (TAIR:AT2G35350.1); Has 1941 Blast hits to 1802 proteins in 214 species: Archae - 0; Bacteria - 0; Metazoa - 375; Fungi - 295; Plants - 1017; Viruses - 0; Other Eukaryotes - 254 (source: NCBI BLink).

NP_850464.1

poltergeist (POL); FUNCTIONS IN: phospholipid binding, protein serine/threonine phosphatase activity; INVOLVED IN: protein myristoylation, regulation of meristem structural organization, protein palmitoylation, regulation of transcription, maintenance of meristem identity; LOCATED IN: nucleus, plasma membrane; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Protein phosphatase 2C-related (InterPro:IPR001932), Protein phosphatase 2C (InterPro:IPR015655), Protein phosphatase 2C, N-terminal (InterPro:IPR014045); BEST Arabidopsis thaliana protein match is: poltergeist like 1 (TAIR:AT2G35350.1); Has 1941 Blast hits to 1802 proteins in 214 species: Archae - 0; Bacteria - 0; Metazoa - 375; Fungi - 295; Plants - 1017; Viruses - 0; Other Eukaryotes - 254 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003071.7 Reference assembly

Range

19277884..19281811 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_180132.3 → NP_850463.1 Protein phosphatase 2C family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_850463.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O80732, Q8RWN7

UniProtKB/TrEMBL

A0A5S9X7X6, A0A654F3W2

Conserved Domains (2) summary

smart00332
Location:273 → 342

PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain

cd00143
Location:534 → 835

PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
NM_180133.2 → NP_850464.1 Protein phosphatase 2C family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_850464.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O80732, Q8RWN7

UniProtKB/TrEMBL

A0A5S9X7X6, A0A654F3W2

Conserved Domains (2) summary

smart00332
Location:273 → 342

PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain

cd00143
Location:534 → 835

PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
NM_001337223.1 → NP_001325392.1 Protein phosphatase 2C family protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/Swiss-Prot

O80732, Q8RWN7

UniProtKB/TrEMBL

A0A5S9X7X6, A0A654F3W2

Conserved Domains (2) summary

smart00332
Location:273 → 342

PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain

cd00143
Location:534 → 835

PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...
NM_001337224.1 → NP_001325391.1 Protein phosphatase 2C family protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/Swiss-Prot

O80732, Q8RWN7

UniProtKB/TrEMBL

A0A5S9X7X6, A0A654F3W2

Conserved Domains (2) summary

smart00332
Location:273 → 342

PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain

cd00143
Location:534 → 835

PP2Cc; Serine/threonine phosphatases, family 2C, catalytic domain; The protein architecture and deduced catalytic mechanism of PP2C phosphatases are similar to the PP1, PP2A, PP2B family of protein Ser/Thr phosphatases, with which PP2C shares no sequence ...