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Rrbp1 ribosome binding protein 1 [ Mus musculus (house mouse) ]

Gene ID: 81910, updated on 2-Nov-2024

Summary

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Official Symbol
Rrbp1provided by MGI
Official Full Name
ribosome binding protein 1provided by MGI
Primary source
MGI:MGI:1932395
See related
Ensembl:ENSMUSG00000027422 AllianceGenome:MGI:1932395
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
p180; mRRp0; mRRp2; ES/130; mRRp10; mRRp41; mRRp47; mRRp1.8; mRRp15a; mRRp15b; mRRp5.4; mRRp16.8; mKIAA1398; 1700087N07Rik; 5730465C04Rik
Summary
Predicted to be involved in signal transduction. Predicted to be located in endoplasmic reticulum. Predicted to be active in endoplasmic reticulum membrane. Is expressed in several structures, including genitourinary system; gut; hemolymphoid system gland; liver; and lung. Orthologous to human RRBP1 (ribosome binding protein 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in placenta adult (RPKM 37.3), liver E18 (RPKM 30.5) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Rrbp1 in Genome Data Viewer
Location:
2 G1; 2 70.89 cM
Exon count:
27
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (143789315..143853216, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (143947395..144011296, complement)

Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene beaded filament structural protein 1, in lens-CP94 Neighboring gene predicted gene 11686 Neighboring gene STARR-seq mESC enhancer starr_05893 Neighboring gene STARR-positive B cell enhancer ABC_E9072 Neighboring gene STARR-seq mESC enhancer starr_05895 Neighboring gene destrin Neighboring gene predicted gene, 33804 Neighboring gene predicted gene, 54119 Neighboring gene STARR-seq mESC enhancer starr_05899 Neighboring gene STARR-positive B cell enhancer ABC_E513 Neighboring gene STARR-positive B cell enhancer ABC_E2050 Neighboring gene STARR-seq mESC enhancer starr_05901 Neighboring gene BANF family member 2 Neighboring gene barrier to autointegration factor 2, opposite strand Neighboring gene STARR-positive B cell enhancer mm9_chr2:143918460-143918761 Neighboring gene predicted gene, 53188

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Identification and characterization of multiple isoforms of a mouse ribosome receptor. Kim YJ, et al. Gene, 2000 Dec 31. PMID 11167022
  2. Mitochondria-ER cooperation: NLRX1 detects mitochondrial protein import stress and promotes mitophagy through the ER protein RRBP1. Killackey SA, et al. Autophagy, 2023 May. PMID 36170592, Free PMC Article
  3. Spatial mapping of hepatic ER and mitochondria architecture reveals zonated remodeling in fasting and obesity. Parlakgül G, et al. Nat Commun, 2024 May 10. PMID 38729945, Free PMC Article
  4. Genetic analysis of albuminuria in a cross between C57BL/6J and DBA/2J mice. Sheehan S, et al. Am J Physiol Renal Physiol, 2007 Nov. PMID 17804484
  5. Identification of positional candidate genes for body weight and adiposity in subcongenic mice. Chiu S, et al. Physiol Genomics, 2007 Sep 19. PMID 17536020

See all (40) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Mitochondria-ER cooperation: NLRX1 detects mitochondrial protein import stress and promotes mitophagy through the ER protein RRBP1.
    Title: Mitochondria-ER cooperation: NLRX1 detects mitochondrial protein import stress and promotes mitophagy through the ER protein RRBP1.
Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (6) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in protein transport IEA
Inferred from Electronic Annotation
more info
  
involved_in signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum ISO
Inferred from Sequence Orthology
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
ribosome-binding protein 1
Names
RRp
mRRp
ribosome receptor protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_024281.2 → NP_077243.2  ribosome-binding protein 1 isoform a

    Status: VALIDATED

    Source sequence(s)
    AK019964, AK039114, AL929550, BE943663, CK787870, W75337
    Consensus CDS
    CCDS38252.1
    UniProtKB/Swiss-Prot
    A2AVJ8, Q99PK5, Q99PK6, Q99PK7, Q99PK8, Q99PK9, Q99PL0, Q99PL1, Q99PL2, Q99PL3, Q99PL4, Q99PL5, Q9CS20
    UniProtKB/TrEMBL
    A2AVJ7
    Related
    ENSMUSP00000016072.6, ENSMUST00000016072.12
    Conserved Domains (4) summary
    PRK02224
    Location:968 → 1448
    PRK02224; chromosome segregation protein; Provisional
    pfam00261
    Location:833 → 1081
    Tropomyosin; Tropomyosin
    pfam05104
    Location:33 → 171
    Rib_recp_KP_reg; Ribosome receptor lysine/proline rich region
    cl02488
    Location:877 → 1071
    SPEC; Spectrin repeats, found in several proteins involved in cytoskeletal structure; family members include spectrin, alpha-actinin and dystrophin; the spectrin repeat forms a three helix bundle with the second helix interrupted by proline in some sequences; ...

  2. NM_133626.2 → NP_598329.1  ribosome-binding protein 1 isoform b

    See identical proteins and their annotated locations for NP_598329.1

    Status: VALIDATED

    Source sequence(s)
    AK039114, AL929550, BQ033142
    Consensus CDS
    CCDS38253.1
    UniProtKB/Swiss-Prot
    Q99PL5
    UniProtKB/TrEMBL
    Q8CAB9
    Related
    ENSMUSP00000040560.6, ENSMUST00000037875.6
    Conserved Domains (1) summary
    pfam05104
    Location:33 → 171
    Rib_recp_KP_reg; Ribosome receptor lysine/proline rich region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000068.8 Reference GRCm39 C57BL/6J

    Range
    143789315..143853216 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006500441.2 → XP_006500504.1  ribosome-binding protein 1 isoform X2

    UniProtKB/TrEMBL
    Q6ZPS0
    Conserved Domains (1) summary
    TIGR02168
    Location:155 → 857
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  2. XM_006500440.2 → XP_006500503.1  ribosome-binding protein 1 isoform X1

    UniProtKB/Swiss-Prot
    A2AVJ8, Q99PK5, Q99PK6, Q99PK7, Q99PK8, Q99PK9, Q99PL0, Q99PL1, Q99PL2, Q99PL3, Q99PL4, Q99PL5, Q9CS20
    Conserved Domains (3) summary
    TIGR00927
    Location:260 → 513
    2A1904; K+-dependent Na+/Ca+ exchanger
    TIGR02168
    Location:760 → 1430
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
    pfam05104
    Location:33 → 168
    Rib_recp_KP_reg; Ribosome receptor lysine/proline rich region

  3. XM_006500443.1 → XP_006500506.1  ribosome-binding protein 1 isoform X4

    UniProtKB/TrEMBL
    Q6ZPS0
    Conserved Domains (1) summary
    TIGR02168
    Location:111 → 813
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  4. XM_006500444.5 → XP_006500507.1  ribosome-binding protein 1 isoform X5

    UniProtKB/TrEMBL
    Q6ZPS0
    Conserved Domains (1) summary
    TIGR02168
    Location:63 → 765
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type

  5. XM_036162731.1 → XP_036018624.1  ribosome-binding protein 1 isoform X3

    UniProtKB/TrEMBL
    Q6ZPS0
    Conserved Domains (1) summary
    TIGR02168
    Location:203 → 847
    SMC_prok_B; chromosome segregation protein SMC, common bacterial type
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99PL5.2 GenPept UniProtKB/Swiss-Prot:Q99PL5

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