U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

SLC25A28 solute carrier family 25 member 28 [ Homo sapiens (human) ]

Gene ID: 81894, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
SLC25A28provided by HGNC
Official Full Name
solute carrier family 25 member 28provided by HGNC
Primary source
HGNC:HGNC:23472
See related
Ensembl:ENSG00000155287 MIM:609767; AllianceGenome:HGNC:23472
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MFRN2; MRS4L; MRS3/4; NPD016
Summary
Predicted to enable ferrous iron transmembrane transporter activity. Predicted to be involved in iron import into the mitochondrion. Located in mitochondrion. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in bone marrow (RPKM 11.6), testis (RPKM 11.1) and 25 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See SLC25A28 in Genome Data Viewer
Location:
10q24.2
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (99610522..99659286, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (100493405..100542276, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (101370279..101380196, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:101292029-101292920 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2692 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2693 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:101299909-101300617 Neighboring gene NK2 homeobox 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3871 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:101355523-101356023 Neighboring gene small nucleolar RNA U13 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:101379422-101380004 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:101380588-101381170 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:101381171-101381752 Neighboring gene SLC25A28 divergent transcript Neighboring gene uncharacterized LOC105378450 Neighboring gene Sharpr-MPRA regulatory region 10719 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2696 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2697 Neighboring gene ectonucleoside triphosphate diphosphohydrolase 7 Neighboring gene EBAG9 pseudogene 1 Neighboring gene cytochrome c oxidase assembly homolog COX15 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3872 Neighboring gene cutC copper transporter

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Mitoferrin-2-dependent mitochondrial iron uptake sensitizes human head and neck squamous carcinoma cells to photodynamic therapy. Hung HI, et al. J Biol Chem, 2013 Jan 4. PMID 23135267, Free PMC Article
  2. Characterization of a novel human putative mitochondrial transporter homologous to the yeast mitochondrial RNA splicing proteins 3 and 4. Li FY, et al. FEBS Lett, 2001 Apr 6. PMID 11297739
  3. Genetic determinants of plasma β₂-glycoprotein I levels: a genome-wide association study in extended pedigrees from Spain. Athanasiadis G, et al. J Thromb Haemost, 2013 Mar. PMID 23279374
  4. Identification of susceptibility loci for colorectal cancer in a genome-wide meta-analysis. Whiffin N, et al. Hum Mol Genet, 2014 Sep 1. PMID 24737748, Free PMC Article
  5. Expressed sequence tag analysis of adult human iris for the NEIBank Project: steroid-response factors and similarities with retinal pigment epithelium. Wistow G, et al. Mol Vis, 2002 Jun 15. PMID 12107412

See all (23) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Compares and contrasts all the known human SLC25A* genes and includes functional information.
    Title: The mitochondrial transporter family SLC25: identification, properties and physiopathology.
  2. Mitoferrin-2-dependent mitochondrial iron uptake sensitizes human head and neck squamous carcinoma cells to photodynamic therapy
    Title: Mitoferrin-2-dependent mitochondrial iron uptake sensitizes human head and neck squamous carcinoma cells to photodynamic therapy.
  3. Observational study of gene-disease association. (HuGE Navigator)
    Title: Genetic variants in nuclear-encoded mitochondrial genes influence AIDS progression.
Submit: New GeneRIF Correction

Phenotypes

Go to the top of the page Help

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci.
EBI GWAS Catalog
Genetic determinants of plasma β₂-glycoprotein I levels: a genome-wide association study in extended pedigrees from Spain.
EBI GWAS Catalog
Identification of susceptibility loci for colorectal cancer in a genome-wide meta-analysis.
EBI GWAS Catalog

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Clone Names

  • DKFZp547C109

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ferrous iron transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in iron import into the mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in mitochondrial inner membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrial membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion HTP PubMed 
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
mitoferrin-2
Names
mitochondrial RNA splicing protein 3/4
mitochondrial RNA-splicing protein 3/4 homolog
mitochondrial iron transporter 2
putative mitochondrial solute carrier
solute carrier family 25 (mitochondrial iron transporter), member 28

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_031212.4 → NP_112489.3  mitoferrin-2

    See identical proteins and their annotated locations for NP_112489.3

    Status: VALIDATED

    Source sequence(s)
    BC047312, CD672723
    Consensus CDS
    CCDS41559.1
    UniProtKB/Swiss-Prot
    Q4VBZ0, Q5T777, Q86VX5, Q969G8, Q96A46, Q9H2J3
    Related
    ENSP00000359526.4, ENST00000370495.6
    Conserved Domains (1) summary
    pfam00153
    Location:71 → 161
    Mito_carr; Mitochondrial carrier protein

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    99610522..99659286 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006718005.5 → XP_006718068.1  mitoferrin-2 isoform X2

    See identical proteins and their annotated locations for XP_006718068.1

    UniProtKB/TrEMBL
    A0A8V8TQS6, A0A8V8TR30
    Conserved Domains (1) summary
    pfam00153
    Location:70 → 154
    Mito_carr; Mitochondrial carrier protein

  2. XM_024448223.2 → XP_024303991.1  mitoferrin-2 isoform X2

    UniProtKB/TrEMBL
    A0A8V8TQS6, A0A8V8TR30
    Conserved Domains (1) summary
    pfam00153
    Location:70 → 154
    Mito_carr; Mitochondrial carrier protein

  3. XM_024448222.2 → XP_024303990.1  mitoferrin-2 isoform X2

    UniProtKB/TrEMBL
    A0A8V8TQS6, A0A8V8TR30
    Conserved Domains (1) summary
    pfam00153
    Location:70 → 154
    Mito_carr; Mitochondrial carrier protein

  4. XM_005270211.6 → XP_005270268.1  mitoferrin-2 isoform X2

    See identical proteins and their annotated locations for XP_005270268.1

    UniProtKB/TrEMBL
    A0A8V8TQS6, A0A8V8TR30
    Related
    ENSP00000514891.1, ENST00000700251.1
    Conserved Domains (1) summary
    pfam00153
    Location:70 → 154
    Mito_carr; Mitochondrial carrier protein

  5. XM_047425809.1 → XP_047281765.1  mitoferrin-2 isoform X2

    UniProtKB/TrEMBL
    A0A8V8TR30

  6. XM_011540239.2 → XP_011538541.1  mitoferrin-2 isoform X1

    UniProtKB/TrEMBL
    A0A8V8TQS6
    Conserved Domains (1) summary
    pfam00153
    Location:79 → 163
    Mito_carr; Mitochondrial carrier protein

  7. XM_047425810.1 → XP_047281766.1  mitoferrin-2 isoform X3

  8. XM_011540244.3 → XP_011538546.1  mitoferrin-2 isoform X4

    Conserved Domains (1) summary
    pfam00153
    Location:71 → 161
    Mito_carr; Mitochondrial carrier protein

  9. XM_006718006.4 → XP_006718069.1  mitoferrin-2 isoform X5

    See identical proteins and their annotated locations for XP_006718069.1

    Conserved Domains (1) summary
    pfam00153
    Location:71 → 161
    Mito_carr; Mitochondrial carrier protein

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    100493405..100542276 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054366870.1 → XP_054222845.1  mitoferrin-2 isoform X2

    UniProtKB/TrEMBL
    A0A8V8TR30

  2. XM_054366872.1 → XP_054222847.1  mitoferrin-2 isoform X2

    UniProtKB/TrEMBL
    A0A8V8TR30

  3. XM_054366869.1 → XP_054222844.1  mitoferrin-2 isoform X1

  4. XM_054366871.1 → XP_054222846.1  mitoferrin-2 isoform X2

    UniProtKB/TrEMBL
    A0A8V8TR30

  5. XM_054366873.1 → XP_054222848.1  mitoferrin-2 isoform X3

  6. XM_054366874.1 → XP_054222849.1  mitoferrin-2 isoform X4

  7. XM_054366875.1 → XP_054222850.1  mitoferrin-2 isoform X5

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96A46.1 GenPept UniProtKB/Swiss-Prot:Q96A46

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Other Literature Sources
Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous