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GPDHC1 6-phosphogluconate dehydrogenase family protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 818752, updated on 18-Sep-2024

Summary

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Official Symbol
GPDHC1
Official Full Name
6-phosphogluconate dehydrogenase family protein
Primary source
TAIR:AT2G41540
Locus tag
AT2G41540
See related
Araport:AT2G41540
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
T32G6.6; T32G6_6
Summary
Encodes a protein with NAD-dependent glycerol-3-phosphate (G3P) dehydrogenase which was shown to complement an Escherichia coli strain: BB20-14, auxotrophic for glycerol/G3P due to a loss-of-function mutation in the gpsA gene.
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Genomic context

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See GPDHC1 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
7
Sequence:
Chromosome: 2; NC_003071.7 (17325846..17329235)

Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene Heat shock protein DnaJ with tetratricopeptide repeat-containing protein Neighboring gene S-formylglutathione hydrolase Neighboring gene Rho termination factor Neighboring gene autoinhibited Ca(2+)-ATPase Neighboring gene pseudo

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Involvement of a glycerol-3-phosphate dehydrogenase in modulating the NADH/NAD+ ratio provides evidence of a mitochondrial glycerol-3-phosphate shuttle in Arabidopsis. Shen W, et al. Plant Cell, 2006 Feb. PMID 16415206, Free PMC Article
  2. Glycerol-3-phosphate metabolism in wheat contributes to systemic acquired resistance against Puccinia striiformis f. sp. tritici. Yang Y, et al. PLoS One, 2013. PMID 24312351, Free PMC Article
  3. Proteome-wide screens for small ubiquitin-like modifier (SUMO) substrates identify Arabidopsis proteins implicated in diverse biological processes. Elrouby N, et al. Proc Natl Acad Sci U S A, 2010 Oct 5. PMID 20855607, Free PMC Article
  4. Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana. Lin X, et al. Nature, 1999 Dec 16. PMID 10617197

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_001036448.2
NM_129717.5
NM_180021.5

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables NAD binding TAS
Traceable Author Statement
more info
 PubMed 
enables glycerol-3-phosphate dehydrogenase (NAD+) activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycerol-3-phosphate catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm ISM
Inferred from Sequence Model
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
6-phosphogluconate dehydrogenase family protein
NP_001031525.1
  • GPDHC1; CONTAINS InterPro DOMAIN/s: 6-phosphogluconate dehydrogenase, C-terminal-like (InterPro:IPR008927), Dehydrogenase, multihelical (InterPro:IPR013328), NAD(P)-binding domain (InterPro:IPR016040), NAD-dependent glycerol-3-phosphate dehydrogenase, C-terminal (InterPro:IPR006109), NAD-dependent glycerol-3-phosphate dehydrogenase, N-terminal (InterPro:IPR011128), NAD-dependent glycerol-3-phosphate dehydrogenase (InterPro:IPR006168); BEST Arabidopsis thaliana protein match is: 6-phosphogluconate dehydrogenase family protein (TAIR:AT3G07690.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
NP_181685.1
  • GPDHC1; CONTAINS InterPro DOMAIN/s: 6-phosphogluconate dehydrogenase, C-terminal-like (InterPro:IPR008927), Dehydrogenase, multihelical (InterPro:IPR013328), NAD(P)-binding domain (InterPro:IPR016040), NAD-dependent glycerol-3-phosphate dehydrogenase, C-terminal (InterPro:IPR006109), NAD-dependent glycerol-3-phosphate dehydrogenase, N-terminal (InterPro:IPR011128), NAD-dependent glycerol-3-phosphate dehydrogenase (InterPro:IPR006168); BEST Arabidopsis thaliana protein match is: 6-phosphogluconate dehydrogenase family protein (TAIR:AT3G07690.1); Has 4956 Blast hits to 4956 proteins in 1719 species: Archae - 20; Bacteria - 3172; Metazoa - 444; Fungi - 126; Plants - 154; Viruses - 0; Other Eukaryotes - 1040 (source: NCBI BLink).
NP_850352.1
  • GPDHC1; CONTAINS InterPro DOMAIN/s: 6-phosphogluconate dehydrogenase, C-terminal-like (InterPro:IPR008927), Dehydrogenase, multihelical (InterPro:IPR013328), NAD(P)-binding domain (InterPro:IPR016040), NAD-dependent glycerol-3-phosphate dehydrogenase, C-terminal (InterPro:IPR006109), NAD-dependent glycerol-3-phosphate dehydrogenase, N-terminal (InterPro:IPR011128), NAD-dependent glycerol-3-phosphate dehydrogenase (InterPro:IPR006168); BEST Arabidopsis thaliana protein match is: 6-phosphogluconate dehydrogenase family protein (TAIR:AT3G07690.1); Has 4956 Blast hits to 4956 proteins in 1719 species: Archae - 20; Bacteria - 3172; Metazoa - 444; Fungi - 126; Plants - 154; Viruses - 0; Other Eukaryotes - 1040 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003071.7 Reference assembly

    Range
    17325846..17329235
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001336924.1 → NP_001325243.1  6-phosphogluconate dehydrogenase family protein [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B9DH11, O22216
    UniProtKB/TrEMBL
    A0A178VTE6, A0A5S9X634
    Conserved Domains (1) summary
    COG0240
    Location:41 → 433
    GpsA; Glycerol-3-phosphate dehydrogenase [Energy production and conversion]

  2. NM_129717.5 → NP_181685.1  6-phosphogluconate dehydrogenase family protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_181685.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B9DH11, O22216
    UniProtKB/TrEMBL
    A0A178VTE6, A0A5S9X634
    Conserved Domains (1) summary
    COG0240
    Location:41 → 433
    GpsA; Glycerol-3-phosphate dehydrogenase [Energy production and conversion]

  3. NM_180021.5 → NP_850352.1  6-phosphogluconate dehydrogenase family protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_850352.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B9DH11, O22216
    UniProtKB/TrEMBL
    A0A178VTE6, A0A5S9X634
    Conserved Domains (1) summary
    COG0240
    Location:41 → 433
    GpsA; Glycerol-3-phosphate dehydrogenase [Energy production and conversion]

  4. NM_001036448.2 → NP_001031525.1  6-phosphogluconate dehydrogenase family protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001031525.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B9DH11, O22216
    UniProtKB/TrEMBL
    A0A178VTE6, A0A5S9X634
    Conserved Domains (1) summary
    COG0240
    Location:41 → 433
    GpsA; Glycerol-3-phosphate dehydrogenase [Energy production and conversion]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O22216.1

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