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GLY1 NAD-dependent glycerol-3-phosphate dehydrogenase family protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 818664, updated on 18-Sep-2024

Summary

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Official Symbol
GLY1
Official Full Name
NAD-dependent glycerol-3-phosphate dehydrogenase family protein
Primary source
TAIR:AT2G40690
Locus tag
AT2G40690
See related
Araport:AT2G40690
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
SFD1; SUPPRESSOR OF FATTY ACID DESATURASE DEFICIENCY 1; T7D17.13; T7D17_13
Summary
Encodes a putative dihydroxyacetone phosphate (DHAP) reductase involved in glycerol-3-phosphate supply within the chloroplast for synthesis of glycerolipids. Mutants have reduced levels of hexadecatrienoic acid, which is rescued by exogenous glycerol-3-phosphate. This gene appears to be involved in the flux of fatty acids in the prokaryotic glyerolipid biosynthesis pathway.
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Genomic context

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See GLY1 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
9
Sequence:
Chromosome: 2; NC_003071.7 (16973992..16976534)

Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene response regulator 16 Neighboring gene pseudo Neighboring gene P-loop containing nucleoside triphosphate hydrolases superfamily protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Over-expression of Arabidopsis thaliana SFD1/GLY1, the gene encoding plastid localized glycerol-3-phosphate dehydrogenase, increases plastidic lipid content in transgenic rice plants. Singh V, et al. J Plant Res, 2016 Mar. PMID 26747130, Free PMC Article
  2. The Arabidopsis thaliana dihydroxyacetone phosphate reductase gene SUPPRESSSOR OF FATTY ACID DESATURASE DEFICIENCY1 is required for glycerolipid metabolism and for the activation of systemic acquired resistance. Nandi A, et al. Plant Cell, 2004 Feb. PMID 14729910, Free PMC Article
  3. A new class of Arabidopsis mutants with reduced hexadecatrienoic acid fatty acid levels. Miquel M, et al. Plant Physiol, 1998 Jul. PMID 9662534, Free PMC Article
  4. Glycerol-3-phosphate metabolism in wheat contributes to systemic acquired resistance against Puccinia striiformis f. sp. tritici. Yang Y, et al. PLoS One, 2013. PMID 24312351, Free PMC Article
  5. AT_CHLORO, a comprehensive chloroplast proteome database with subplastidial localization and curated information on envelope proteins. Ferro M, et al. Mol Cell Proteomics, 2010 Jun. PMID 20061580, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Arabidopsis SFD1 localizes in rice plastids and its over-expression increases plastidic membrane lipid content in transgenic rice plants without any major impact on ER lipids.
    Title: Over-expression of Arabidopsis thaliana SFD1/GLY1, the gene encoding plastid localized glycerol-3-phosphate dehydrogenase, increases plastidic lipid content in transgenic rice plants.
Submit: New GeneRIF Correction

General gene information

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Homology

NM_001336857.1
NM_001336858.1
NM_129631.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables NAD binding IEA
Inferred from Electronic Annotation
more info
  
enables glycerol-3-phosphate dehydrogenase (NAD+) activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in glycerol-3-phosphate catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within glycerolipid biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within glycerolipid metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in glycerophospholipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within systemic acquired resistance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in chloroplast envelope HDA PubMed 
located_in cytoplasm ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
NAD-dependent glycerol-3-phosphate dehydrogenase family protein
NP_565939.1
  • GLY1; FUNCTIONS IN: glycerol-3-phosphate dehydrogenase [NAD+] activity; INVOLVED IN: systemic acquired resistance, glycerol-3-phosphate metabolic process, glycerolipid biosynthetic process, glycerolipid metabolic process; LOCATED IN: glycerol-3-phosphate dehydrogenase complex, cytoplasm; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: 6-phosphogluconate dehydrogenase, C-terminal-like (InterPro:IPR008927), Dehydrogenase, multihelical (InterPro:IPR013328), NAD(P)-binding domain (InterPro:IPR016040), NAD-dependent glycerol-3-phosphate dehydrogenase, C-terminal (InterPro:IPR006109), NAD-dependent glycerol-3-phosphate dehydrogenase, N-terminal (InterPro:IPR011128), NAD-dependent glycerol-3-phosphate dehydrogenase (InterPro:IPR006168); BEST Arabidopsis thaliana protein match is: NAD-dependent glycerol-3-phosphate dehydrogenase family protein (TAIR:AT5G40610.1); Has 8663 Blast hits to 8662 proteins in 2795 species: Archae - 24; Bacteria - 5277; Metazoa - 643; Fungi - 297; Plants - 161; Viruses - 0; Other Eukaryotes - 2261 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003071.7 Reference assembly

    Range
    16973992..16976534
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_129631.3 → NP_565939.1  NAD-dependent glycerol-3-phosphate dehydrogenase family protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_565939.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q949Q0
    UniProtKB/TrEMBL
    A0A178VQD1, A0A5S9X5T9
    Conserved Domains (1) summary
    PRK00094
    Location:87 → 413
    gpsA; NAD(P)H-dependent glycerol-3-phosphate dehydrogenase

  2. NM_001336858.1 → NP_001324724.1  NAD-dependent glycerol-3-phosphate dehydrogenase family protein [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q949Q0
    UniProtKB/TrEMBL
    A0A178VQD1, A0A5S9X5T9
    Conserved Domains (1) summary
    PRK00094
    Location:87 → 413
    gpsA; NAD(P)H-dependent glycerol-3-phosphate dehydrogenase

  3. NM_001336857.1 → NP_001324723.1  NAD-dependent glycerol-3-phosphate dehydrogenase family protein [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8B101
    Conserved Domains (1) summary
    PRK00094
    Location:1 → 312
    gpsA; NAD(P)H-dependent glycerol-3-phosphate dehydrogenase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q949Q0.1

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