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DREB2C Integrase-type DNA-binding superfamily protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 818627, updated on 18-Sep-2024

Summary

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Official Symbol
DREB2C
Official Full Name
Integrase-type DNA-binding superfamily protein
Primary source
TAIR:AT2G40340
Locus tag
AT2G40340
See related
Araport:AT2G40340
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
AtERF48; T7M7.18
Summary
Encodes a member of the DREB subfamily A-2 of ERF/AP2 transcription factor family. The protein contains one AP2 domain. There are eight members in this subfamily including DREB2A AND DREB2B that are involved in response to drought.
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Genomic context

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See DREB2C in Genome Data Viewer
Location:
chromosome: 2
Exon count:
3
Sequence:
Chromosome: 2; NC_003071.7 (16848160..16850494, complement)

Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene TRICHOME BIREFRINGENCE-LIKE 33 Neighboring gene PYR1-like 6 Neighboring gene Integrase-type DNA-binding superfamily protein Neighboring gene Transducin/WD40 repeat-like superfamily protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Arabidopsis DREB2C modulates ABA biosynthesis during germination. Je J, et al. Biochem Biophys Res Commun, 2014 Sep 12. PMID 25150152
  2. A proximal promoter region of Arabidopsis DREB2C confers tissue-specific expression under heat stress. Chen H, et al. J Integr Plant Biol, 2012 Sep. PMID 22716647
  3. Overexpression of Arabidopsis dehydration- responsive element-binding protein 2C confers tolerance to oxidative stress. Hwang JE, et al. Mol Cells, 2012 Feb. PMID 22286229, Free PMC Article
  4. Identification of potential DREB2C targets in Arabidopsis thaliana plants overexpressing DREB2C using proteomic analysis. Lee K, et al. Mol Cells, 2009 Oct 31. PMID 19830397
  5. Over-expression of the Arabidopsis DRE/CRT-binding transcription factor DREB2C enhances thermotolerance. Lim CJ, et al. Biochem Biophys Res Commun, 2007 Oct 19. PMID 17716623

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. These results demonstrate that VOZ1 functions as a negative regulator of heat stress (HS)-inducible DREB2C signaling by blocking access to the AP2 DNA-binding domain of DREB2C.
    Title: VOZ1, a transcriptional repressor of DREB2C, mediates heat stress responses in Arabidopsis.
  2. DREB2C functions as transcriptional activator that promotes NaCl tolerance, in part through upregulation of the stress-responsive gene COR15A.
    Title: Ectopic expression of an Arabidopsis dehydration-responsive element-binding factor DREB2C improves salt stress tolerance in crucifers.
  3. results suggest that DREB2C is a stress- and ABA-inducible gene that acts as a positive regulator of ABA biosynthesis in germinating seeds through activating NCED9 expression
    Title: Arabidopsis DREB2C modulates ABA biosynthesis during germination.
  4. We propose that AtCYS4 functions in thermotolerance under the control of the DREB2C cascade
    Title: DREB2C acts as a transcriptional activator of the thermo tolerance-related phytocystatin 4 (AtCYS4) gene.
  5. The TATA-proximal region and some latent trans-acting factors may cooperate in heat shock-induced activation of the Arabidopsis DREB2C promoter.
    Title: A proximal promoter region of Arabidopsis DREB2C confers tissue-specific expression under heat stress.
  6. These results suggest that DREB2C plays an important role in promoting oxidative stress tolerance in Arabidopsis.
    Title: Overexpression of Arabidopsis dehydration- responsive element-binding protein 2C confers tolerance to oxidative stress.
  7. these results indicate that DREB2C and HsfA3 are key players in regulating the heat tolerance of Arabidopsis.
    Title: Arabidopsis DREB2C functions as a transcriptional activator of HsfA3 during the heat stress response.
  8. Overexpression of DREB2C affects the expression of stress-responsive genes and affects ABA sensitivity.
    Title: DREB2C interacts with ABF2, a bZIP protein regulating abscisic acid-responsive gene expression, and its overexpression affects abscisic acid sensitivity.
  9. identify possible targets of DREB2C transcription factors at the protein level
    Title: Identification of potential DREB2C targets in Arabidopsis thaliana plants overexpressing DREB2C using proteomic analysis.
  10. Data suggest that DREB2C is a regulator of heat stress tolerance in Arabidopsis.
    Title: Over-expression of the Arabidopsis DRE/CRT-binding transcription factor DREB2C enhances thermotolerance.
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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_001336829.1
NM_001336831.1
NM_001336832.1
NM_001336833.1
NM_129594.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity IEA
Inferred from Electronic Annotation
more info
  
enables DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within heat acclimation IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to abscisic acid IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
Integrase-type DNA-binding superfamily protein
NP_565929.1
  • DREB2C; CONTAINS InterPro DOMAIN/s: DNA-binding, integrase-type (InterPro:IPR016177), Pathogenesis-related transcriptional factor/ERF, DNA-binding (InterPro:IPR001471); BEST Arabidopsis thaliana protein match is: Integrase-type DNA-binding superfamily protein (TAIR:AT2G40350.1); Has 5601 Blast hits to 5564 proteins in 248 species: Archae - 0; Bacteria - 0; Metazoa - 0; Fungi - 0; Plants - 5583; Viruses - 4; Other Eukaryotes - 14 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003071.7 Reference assembly

    Range
    16848160..16850494 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001336830.1 → NP_001325150.1  Integrase-type DNA-binding superfamily protein [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8B298, A0A7G2ECR8, A0A7G2ED46
    Conserved Domains (1) summary
    smart00380
    Location:72 → 134
    AP2; DNA-binding domain in plant proteins such as APETALA2 and EREBPs

  2. NM_129594.3 → NP_565929.1  Integrase-type DNA-binding superfamily protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_565929.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q0V7R5, Q8LFR2, Q8S8E2, Q9S7X4
    UniProtKB/TrEMBL
    A0A178VWP8, A0A5S9X5P2, A0A7G2ECR8
    Conserved Domains (1) summary
    smart00380
    Location:72 → 134
    AP2; DNA-binding domain in plant proteins such as APETALA2 and EREBPs

  3. NM_001336829.1 → NP_001325154.1  Integrase-type DNA-binding superfamily protein [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8B2A0

  4. NM_001336831.1 → NP_001325151.1  Integrase-type DNA-binding superfamily protein [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8B2A0

  5. NM_001336832.1 → NP_001325152.1  Integrase-type DNA-binding superfamily protein [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8B2A0

  6. NM_001336833.1 → NP_001325153.1  Integrase-type DNA-binding superfamily protein [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8B2B1, A0A7G2ECR8
    Conserved Domains (1) summary
    smart00380
    Location:79 → 141
    AP2; DNA-binding domain in plant proteins such as APETALA2 and EREBPs
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8LFR2.2

Gene LinkOut

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