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AKR4C8 NAD(P)-linked oxidoreductase superfamily protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 818353, updated on 18-Sep-2024

Summary

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Official Symbol
AKR4C8
Official Full Name
NAD(P)-linked oxidoreductase superfamily protein
Primary source
TAIR:AT2G37760
Locus tag
AT2G37760
See related
Araport:AT2G37760
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
Aldo-keto reductase family 4 member C8; T8P21.6
Summary
Encodes an NADPH-dependent aldo-keto reductase that can act on a wide variety of substrates in vitro including aliphatic and aromatic aldehydes and steroids. Transcript levels for this gene are up-regulated in response to cold, salt, and drought stress.
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Genomic context

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See AKR4C8 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
8
Sequence:
Chromosome: 2; NC_003071.7 (15831656..15833921)

Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene zinc-finger protein 10 Neighboring gene uncharacterized protein Neighboring gene NAD(P)-linked oxidoreductase superfamily protein Neighboring gene Cysteine/Histidine-rich C1 domain family protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterization of two novel aldo-keto reductases from Arabidopsis: expression patterns, broad substrate specificity, and an open active-site structure suggest a role in toxicant metabolism following stress. Simpson PJ, et al. J Mol Biol, 2009 Sep 18. PMID 19616008
  2. A proteomic strategy for global analysis of plant protein complexes. Aryal UK, et al. Plant Cell, 2014 Oct. PMID 25293756, Free PMC Article
  3. Global Analysis of Membrane-associated Protein Oligomerization Using Protein Correlation Profiling. McBride Z, et al. Mol Cell Proteomics, 2017 Nov. PMID 28887381, Free PMC Article
  4. Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana. Lin X, et al. Nature, 1999 Dec 16. PMID 10617197

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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General gene information

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Homology

NM_001084550.1
NM_001124993.1
NM_001336674.1
NM_129332.5
NM_201897.4
NM_201898.2

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables NADP+ binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables aldo-keto reductase (NADPH) activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
enables steroid dehydrogenase activity IDA
Inferred from Direct Assay
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within response to cold IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to cold IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within response to salt stress IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to salt stress IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within response to water deprivation IEP
Inferred from Expression Pattern
more info
 PubMed 
involved_in response to water deprivation IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm ISM
Inferred from Sequence Model
more info
  
located_in cytosol HDA PubMed 
located_in endoplasmic reticulum HDA PubMed 

General protein information

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Preferred Names
NAD(P)-linked oxidoreductase superfamily protein
NP_001078019.1
  • NAD(P)-linked oxidoreductase superfamily protein; FUNCTIONS IN: oxidoreductase activity; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Aldo/keto reductase (InterPro:IPR001395), Aldo/keto reductase subgroup (InterPro:IPR020471), Aldo/keto reductase, conserved site (InterPro:IPR018170); BEST Arabidopsis thaliana protein match is: NAD(P)-linked oxidoreductase superfamily protein (TAIR:AT2G37770.2); Has 25660 Blast hits to 25635 proteins in 2483 species: Archae - 410; Bacteria - 17272; Metazoa - 2121; Fungi - 1835; Plants - 1211; Viruses - 0; Other Eukaryotes - 2811 (source: NCBI BLink).
NP_001118465.1
  • NAD(P)-linked oxidoreductase superfamily protein; FUNCTIONS IN: oxidoreductase activity; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Aldo/keto reductase (InterPro:IPR001395), Aldo/keto reductase subgroup (InterPro:IPR020471), Aldo/keto reductase, conserved site (InterPro:IPR018170); BEST Arabidopsis thaliana protein match is: NAD(P)-linked oxidoreductase superfamily protein (TAIR:AT2G37770.2); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
NP_565871.1
  • NAD(P)-linked oxidoreductase superfamily protein; FUNCTIONS IN: oxidoreductase activity; INVOLVED IN: response to cadmium ion; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Aldo/keto reductase (InterPro:IPR001395), Aldo/keto reductase subgroup (InterPro:IPR020471), Aldo/keto reductase, conserved site (InterPro:IPR018170); BEST Arabidopsis thaliana protein match is: NAD(P)-linked oxidoreductase superfamily protein (TAIR:AT2G37790.1); Has 25671 Blast hits to 25646 proteins in 2485 species: Archae - 414; Bacteria - 17274; Metazoa - 2121; Fungi - 1833; Plants - 1216; Viruses - 0; Other Eukaryotes - 2813 (source: NCBI BLink).
NP_973626.2
  • NAD(P)-linked oxidoreductase superfamily protein; FUNCTIONS IN: oxidoreductase activity; INVOLVED IN: response to cadmium ion; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Aldo/keto reductase (InterPro:IPR001395), Aldo/keto reductase subgroup (InterPro:IPR020471), Aldo/keto reductase, conserved site (InterPro:IPR018170); BEST Arabidopsis thaliana protein match is: NAD(P)-linked oxidoreductase superfamily protein (TAIR:AT2G37790.1); Has 25671 Blast hits to 25646 proteins in 2485 species: Archae - 414; Bacteria - 17274; Metazoa - 2121; Fungi - 1833; Plants - 1216; Viruses - 0; Other Eukaryotes - 2813 (source: NCBI BLink).
NP_973627.1
  • NAD(P)-linked oxidoreductase superfamily protein; FUNCTIONS IN: oxidoreductase activity; INVOLVED IN: response to cadmium ion; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Aldo/keto reductase (InterPro:IPR001395), Aldo/keto reductase subgroup (InterPro:IPR020471), Aldo/keto reductase, conserved site (InterPro:IPR018170); BEST Arabidopsis thaliana protein match is: NAD(P)-linked oxidoreductase superfamily protein (TAIR:AT2G37770.2); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003071.7 Reference assembly

    Range
    15831656..15833921
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001336673.1 → NP_001324984.1  NAD(P)-linked oxidoreductase superfamily protein [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8B1V1, A0A654FAD5

  2. NM_129332.5 → NP_565871.1  NAD(P)-linked oxidoreductase superfamily protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_565871.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B3H474, O80944, Q3E6N6, Q3EBK9, Q93YR4
    UniProtKB/TrEMBL
    A0A178VZ90, A0A5S9X4W0, A0A654FAD5
    Conserved Domains (1) summary
    cd19125
    Location:6 → 288
    AKR_AKR4C1-15; AKR4C family of aldo-keto reductase (AKR)

  3. NM_201897.4 → NP_973626.2  NAD(P)-linked oxidoreductase superfamily protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_973626.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B3H474, O80944, Q3E6N6, Q3EBK9, Q93YR4
    UniProtKB/TrEMBL
    A0A178VZ90, A0A5S9X4W0, A0A654FAD5
    Conserved Domains (1) summary
    cd19125
    Location:6 → 288
    AKR_AKR4C1-15; AKR4C family of aldo-keto reductase (AKR)

  4. NM_001084550.1 → NP_001078019.1  NAD(P)-linked oxidoreductase superfamily protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001078019.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A654FAD5
    Conserved Domains (2) summary
    COG0656
    Location:7 → 273
    ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]
    COG0667
    Location:11 → 277
    Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]

  5. NM_201898.2 → NP_973627.1  NAD(P)-linked oxidoreductase superfamily protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_973627.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A654FAD5
    Conserved Domains (2) summary
    COG0656
    Location:7 → 273
    ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]
    COG0667
    Location:11 → 277
    Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]

  6. NM_001124993.1 → NP_001118465.1  NAD(P)-linked oxidoreductase superfamily protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001118465.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A654FAD5
    Conserved Domains (2) summary
    COG0656
    Location:7 → 273
    ARA1; Aldo/keto reductase, related to diketogulonate reductase [Secondary metabolites biosynthesis, transport and catabolism]
    COG0667
    Location:11 → 277
    Tas; Predicted oxidoreductase (related to aryl-alcohol dehydrogenase) [General function prediction only]

  7. NM_001336674.1 → NP_001324985.1  NAD(P)-linked oxidoreductase superfamily protein [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8B1V1, A0A654FAD5
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O80944.2

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