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BLH1 BEL1-like homeodomain 1 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 818167, updated on 15-Oct-2023

Summary

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Gene symbol
BLH1
Gene description
BEL1-like homeodomain 1
Primary source
Araport:AT2G35940
Locus tag
AT2G35940
See related
TAIR:AT2G35940
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
BEL1-like homeodomain 1; EDA29; embryo sac development arrest 29; F11F19.15; F11F19_15
Summary
Encodes a member of the BEL-like homeodomain protein family. Ecotopic expression in the embryo sac leads to defects in nuclear migration and cellularization and embryo sacs with multiple egg cells. Loss of function alleles have no female gametophyte defects. The ecotopic expression phenotype requires KNAT3 because it can be suppressed by loss of KNAT3 function alleles. Localized to the nucleus but interaction with OFP1 relocates it to the cytoplasm.
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Genomic context

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See BLH1 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
6
Sequence:
Chromosome: 2; NC_003071.7 (15088762..15092415, complement)

Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene RNA helicase family protein Neighboring gene uncharacterized protein Neighboring gene plant U-box 23 Neighboring gene ncRNA Neighboring gene embryo sac development arrest 12 Neighboring gene NDR1/HIN1-like 12

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Bell-like homeodomain selectively regulates the high-irradiance response of phytochrome A. Staneloni RJ, et al. Proc Natl Acad Sci U S A, 2009 Aug 11. PMID 19666535, Free PMC Article
  2. The endophytic fungus Piriformospora indica stimulates the expression of nitrate reductase and the starch-degrading enzyme glucan-water dikinase in tobacco and Arabidopsis roots through a homeodomain transcription factor that binds to a conserved motif in their promoters. Sherameti I, et al. J Biol Chem, 2005 Jul 15. PMID 15710607
  3. Genome-wide gene expression profiling in Arabidopsis thaliana reveals new targets of abscisic acid and largely impaired gene regulation in the abi1-1 mutant. Hoth S, et al. J Cell Sci, 2002 Dec 15. PMID 12432076
  4. BLH1 and KNAT3 modulate ABA responses during germination and early seedling development in Arabidopsis. Kim D, et al. Plant J, 2013 Sep. PMID 23663178
  5. Cell-fate switch of synergid to egg cell in Arabidopsis eostre mutant embryo sacs arises from misexpression of the BEL1-like homeodomain gene BLH1. Pagnussat GC, et al. Plant Cell, 2007 Nov. PMID 18055603, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. BLH1 and KNAT3 together modulate seed germination and early seedling development by directly regulating ABI3 expression.
    Title: BLH1 and KNAT3 modulate ABA responses during germination and early seedling development in Arabidopsis.
  2. BLH1 specifically regulates high-irradiance response and not very-low-fluence response of phytochrome A.
    Title: Bell-like homeodomain selectively regulates the high-irradiance response of phytochrome A.
  3. The eostre phenotype is caused by misexpression of the homeodomain gene BEL1-like homeodomain 1 (BLH1) in the embryo sac.
    Title: Cell-fate switch of synergid to egg cell in Arabidopsis eostre mutant embryo sacs arises from misexpression of the BEL1-like homeodomain gene BLH1.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_001036413.3
NM_129153.3
NM_179925.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein heterodimerization activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within polar nucleus fusion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to abscisic acid IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within response to continuous far red light stimulus by the high-irradiance response system IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to symbiotic fungus IEP
Inferred from Expression Pattern
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
BEL1-like homeodomain 1
NP_001031490.1
  • BEL1-like homeodomain 1 (BLH1); CONTAINS InterPro DOMAIN/s: Homeobox (InterPro:IPR001356), Homeodomain-like (InterPro:IPR009057), POX (InterPro:IPR006563), Homeodomain-related (InterPro:IPR012287); BEST Arabidopsis thaliana protein match is: BEL1-like homeodomain 6 (TAIR:AT4G34610.2); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
NP_181138.1
  • BEL1-like homeodomain 1 (BLH1); CONTAINS InterPro DOMAIN/s: Homeobox (InterPro:IPR001356), Homeodomain-like (InterPro:IPR009057), POX (InterPro:IPR006563), Homeodomain-related (InterPro:IPR012287); BEST Arabidopsis thaliana protein match is: BEL1-like homeodomain 6 (TAIR:AT4G34610.2); Has 71711 Blast hits to 13510 proteins in 414 species: Archae - 28; Bacteria - 75; Metazoa - 3080; Fungi - 2154; Plants - 2539; Viruses - 2; Other Eukaryotes - 63833 (source: NCBI BLink).
NP_850256.1
  • BEL1-like homeodomain 1 (BLH1); CONTAINS InterPro DOMAIN/s: Homeobox (InterPro:IPR001356), Homeodomain-like (InterPro:IPR009057), POX (InterPro:IPR006563), Homeodomain-related (InterPro:IPR012287); BEST Arabidopsis thaliana protein match is: BEL1-like homeodomain 6 (TAIR:AT4G34610.2); Has 71711 Blast hits to 13510 proteins in 414 species: Archae - 28; Bacteria - 75; Metazoa - 3080; Fungi - 2154; Plants - 2539; Viruses - 2; Other Eukaryotes - 63833 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003071.7 Reference assembly

    Range
    15088762..15092415 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_129153.3 → NP_181138.1  BEL1-like homeodomain 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_181138.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q42302, Q94KL4, Q9SJ56
    UniProtKB/TrEMBL
    A0A178VQI8, A0A654F4I7
    Conserved Domains (2) summary
    pfam05920
    Location:403 → 442
    Homeobox_KN; Homeobox KN domain
    pfam07526
    Location:190 → 332
    POX; Associated with HOX

  2. NM_179925.3 → NP_850256.1  BEL1-like homeodomain 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_850256.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q42302, Q94KL4, Q9SJ56
    UniProtKB/TrEMBL
    A0A178VQI8, A0A654F4I7
    Conserved Domains (2) summary
    pfam05920
    Location:403 → 442
    Homeobox_KN; Homeobox KN domain
    pfam07526
    Location:190 → 332
    POX; Associated with HOX

  3. NM_001036413.3 → NP_001031490.1  BEL1-like homeodomain 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001031490.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q42302, Q94KL4, Q9SJ56
    UniProtKB/TrEMBL
    A0A178VQI8, A0A654F4I7
    Conserved Domains (2) summary
    pfam05920
    Location:403 → 442
    Homeobox_KN; Homeobox KN domain
    pfam07526
    Location:190 → 332
    POX; Associated with HOX
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9SJ56.1

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