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FAH1 fatty acid hydroxylase 1 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 818042, updated on 18-Sep-2024

Summary

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Official Symbol
FAH1
Official Full Name
fatty acid hydroxylase 1
Primary source
TAIR:AT2G34770
Locus tag
AT2G34770
See related
Araport:AT2G34770
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ARABIDOPSIS FATTY ACID HYDROXYLASE 1; ATFAH1; FAH1P; fatty acid hydroxylase 1; T29F13.2; T29F13_2
Summary
encodes a fatty acid hydroxylase, required for the AtBI-1-mediated suppression of programmed cell death.
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Genomic context

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See FAH1 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
7
Sequence:
Chromosome: 2; NC_003071.7 (14665667..14668250)

Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene myosin heavy chain-like protein Neighboring gene protein phosphatase 2C family protein Neighboring gene RNA polymerase I specific transcription initiation factor RRN3 protein Neighboring gene miscRNA Neighboring gene ncRNA Neighboring gene maternal effect embryo arrest 22 Neighboring gene ncRNA Neighboring gene FAD-binding Berberine family protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Arabidopsis mutants of sphingolipid fatty acid α-hydroxylases accumulate ceramides and salicylates. König S, et al. New Phytol, 2012 Dec. PMID 23025549
  2. Arabidopsis sphingolipid fatty acid 2-hydroxylases (AtFAH1 and AtFAH2) are functionally differentiated in fatty acid 2-hydroxylation and stress responses. Nagano M, et al. Plant Physiol, 2012 Jul. PMID 22635113, Free PMC Article
  3. Functional association of cell death suppressor, Arabidopsis Bax inhibitor-1, with fatty acid 2-hydroxylation through cytochrome b₅. Nagano M, et al. Plant J, 2009 Apr. PMID 19054355
  4. Fah1p, a Saccharomyces cerevisiae cytochrome b5 fusion protein, and its Arabidopsis thaliana homolog that lacks the cytochrome b5 domain both function in the alpha-hydroxylation of sphingolipid-associated very long chain fatty acids. Mitchell AG, et al. J Biol Chem, 1997 Nov 7. PMID 9353282
  5. Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana. Lin X, et al. Nature, 1999 Dec 16. PMID 10617197

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. FAH1 enzyme is capable of forming alpha-hydroxylated ceramides.
    Title: Arabidopsis mutants of sphingolipid fatty acid α-hydroxylases accumulate ceramides and salicylates.
  2. AtFAH1 and AtFAH2 had fatty acid 2-hydroxylase activity, and the interaction with Arabidopsis cytochrome b5 was needed for the sufficient activity.
    Title: Arabidopsis sphingolipid fatty acid 2-hydroxylases (AtFAH1 and AtFAH2) are functionally differentiated in fatty acid 2-hydroxylation and stress responses.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_129030.2

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables fatty acid 2-hydroxylase activity IEA
Inferred from Electronic Annotation
more info
  
enables fatty acid 2-hydroxylase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables iron ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within negative regulation of programmed cell death IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within very long-chain fatty acid metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within very long-chain fatty acid metabolic process IGI
Inferred from Genetic Interaction
more info
 PubMed 

General protein information

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Preferred Names
fatty acid hydroxylase 1
NP_181023.1
  • fatty acid hydroxylase 1 (FAH1); FUNCTIONS IN: fatty acid alpha-hydroxylase activity, catalytic activity; INVOLVED IN: very long-chain fatty acid metabolic process, negative regulation of programmed cell death; LOCATED IN: endoplasmic reticulum; EXPRESSED IN: 24 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Fatty acid hydroxylase (InterPro:IPR006694); BEST Arabidopsis thaliana protein match is: fatty acid hydroxylase 2 (TAIR:AT4G20870.1); Has 784 Blast hits to 784 proteins in 354 species: Archae - 0; Bacteria - 388; Metazoa - 105; Fungi - 140; Plants - 78; Viruses - 0; Other Eukaryotes - 73 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003071.7 Reference assembly

    Range
    14665667..14668250
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_129030.2 → NP_181023.1  fatty acid hydroxylase 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_181023.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O48916
    UniProtKB/TrEMBL
    A0A178W0P1, A0A5S9X3X1
    Conserved Domains (1) summary
    PLN02434
    Location:1 → 237
    PLN02434; fatty acid hydroxylase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O48916.1

Gene LinkOut

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