CYP710A1 cytochrome P450, family 710, subfamily A, polypeptide 1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

Official Symbol: CYP710A1
Official Full Name: cytochrome P450, family 710, subfamily A, polypeptide 1
Primary source: TAIR:AT2G34500
Locus tag: AT2G34500
See related: Araport:AT2G34500
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: cytochrome P450; F13P17.35; family 710; polypeptide 1; subfamily A
Summary: Encodes a protein with C22-sterol desaturase activity. The enzyme was shown to catalyze in the presence of NADPH the conversion of β-sitosterol to stigmasterol, but not that of 24-<i>epi</i>-campesterol to brassicasterol (unlike CYP710A2).
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Chromosome 2 - NC_003071.7 Genomic Context describing neighboring genes

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Arabidopsis histone H3 lysine 9 methyltransferases KYP/SUVH5/6 are involved in leaf development by interacting with AS1-AS2 to repress KNAT1 and KNAT2.
Title: Arabidopsis histone H3 lysine 9 methyltransferases KYP/SUVH5/6 are involved in leaf development by interacting with AS1-AS2 to repress KNAT1 and KNAT2.
The functions of CYP710A1 and CYP710A4 in stigmasterol synthesis are reported.
Title: Overexpression of CYP710A1 and CYP710A4 in transgenic Arabidopsis plants increases the level of stigmasterol at the expense of sitosterol.
In arabidopsis, cyp710A family may encode P450s of sterol C-22 desaturases in different organisms. [cyp710A1]
Title: Cytochrome P450 CYP710A encodes the sterol C-22 desaturase in Arabidopsis and tomato.

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NM_129002.3

Function	Evidence Code	Pubs
enables C-22 sterol desaturase (NADPH) activity	IDA Inferred from Direct Assay more info	PubMed
enables heme binding	IEA Inferred from Electronic Annotation more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in sterol biosynthetic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	ISM Inferred from Sequence Model more info

NP_180997.1

cytochrome P450, family 710, subfamily A, polypeptide 1 (CYP710A1); FUNCTIONS IN: C-22 sterol desaturase activity, oxygen binding; INVOLVED IN: oxidation reduction; LOCATED IN: endomembrane system; EXPRESSED IN: 14 plant structures; EXPRESSED DURING: LP.04 four leaves visible, 4 anthesis, petal differentiation and expansion stage; CONTAINS InterPro DOMAIN/s: Cytochrome P450 (InterPro:IPR001128), Cytochrome P450, conserved site (InterPro:IPR017972), Cytochrome P450, E-class, group I (InterPro:IPR002401); BEST Arabidopsis thaliana protein match is: cytochrome P450, family 710, subfamily A, polypeptide 2 (TAIR:AT2G34490.1); Has 25674 Blast hits to 25623 proteins in 1435 species: Archae - 46; Bacteria - 2777; Metazoa - 10394; Fungi - 4411; Plants - 7239; Viruses - 0; Other Eukaryotes - 807 (source: NCBI BLink).

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