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COQ3 coenzyme Q 3 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 817642, updated on 18-Sep-2024

Summary

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Official Symbol
COQ3
Official Full Name
coenzyme Q 3
Primary source
TAIR:AT2G30920
Locus tag
AT2G30920
See related
Araport:AT2G30920
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ATCOQ3; coenzyme Q 3; EMB3002; embryo defective 3002; F7F1.13; F7F1_13
Summary
The enzyme encoded by this gene has been shown to complement the Saccharomyces cerevisiae coq3 mutation and, therefore, to have hexaprenyldihydroxybenzoate methyltransferase activity. It is however likely that, in Arabidopsis, the enzyme catalyzes the methylation of nonaprenyldihydroxybenzoate as it is the prevalent polyprenoid in this plant species. The enzyme is a mitochondrial-localized methyltransferase involved in ubiquinone biosynthesis.
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Genomic context

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See COQ3 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
10
Sequence:
Chromosome: 2; NC_003071.7 (13157089..13160886, complement)

Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene glutathione S-transferase PHI 10 Neighboring gene Pleckstrin homology (PH) domain-containing protein Neighboring gene Cytochrome b561/ferric reductase transmembrane protein family Neighboring gene TRICHOME BIREFRINGENCE-LIKE 43 Neighboring gene actin-related protein C1A Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cloning and functional expression of AtCOQ3, the Arabidopsis homologue of the yeast COQ3 gene, encoding a methyltransferase from plant mitochondria involved in ubiquinone biosynthesis. Avelange-Macherel MH, et al. Plant J, 1998 Apr. PMID 9628017
  2. Evidence for network evolution in an Arabidopsis interactome map. Arabidopsis Interactome Mapping Consortium. Science, 2011 Jul 29. PMID 21798944, Free PMC Article
  3. Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana. Lin X, et al. Nature, 1999 Dec 16. PMID 10617197

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_001336307.1
NM_128644.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables 2-polyprenyl-6-methoxy-1,4-benzoquinone methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables 3,4-dihydroxy-5-polyprenylbenzoic acid O-methyltransferase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables 3-demethylubiquinol-n 3-O-methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within embryo development ending in seed dormancy NAS
Non-traceable Author Statement
more info
  
acts_upstream_of_or_within methylation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in ubiquinone biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within ubiquinone biosynthetic process IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within ubiquinone biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrial envelope IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
coenzyme Q 3
NP_180649.1
  • coenzyme Q 3 (COQ3); CONTAINS InterPro DOMAIN/s: Methyltransferase type 11 (InterPro:IPR013216), Ubiquinone biosynthesis O-methyltransferase (InterPro:IPR010233); Has 7105 Blast hits to 7105 proteins in 1734 species: Archae - 120; Bacteria - 4165; Metazoa - 130; Fungi - 181; Plants - 86; Viruses - 0; Other Eukaryotes - 2423 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003071.7 Reference assembly

    Range
    13157089..13160886 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_128644.4 → NP_180649.1  coenzyme Q 3 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_180649.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O49354, O80857, Q94AS6
    UniProtKB/TrEMBL
    A0A178VTB0, A0A5S9X330, A0A654EZ36, Q8LG57
    Conserved Domains (1) summary
    PLN02396
    Location:1 → 322
    PLN02396; hexaprenyldihydroxybenzoate methyltransferase

  2. NM_001336307.1 → NP_001324991.1  coenzyme Q 3 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O49354, O80857, Q94AS6
    UniProtKB/TrEMBL
    A0A178VTB0, A0A5S9X330, A0A654EZ36, Q8LG57
    Conserved Domains (1) summary
    PLN02396
    Location:1 → 322
    PLN02396; hexaprenyldihydroxybenzoate methyltransferase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O49354.2

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