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LHW transcription factor-like protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 817265, updated on 18-Sep-2024

Summary

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Official Symbol
LHW
Official Full Name
transcription factor-like protein
Primary source
TAIR:AT2G27230
Locus tag
AT2G27230
See related
Araport:AT2G27230
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
F12K2.19; F12K2_19; LONESOME HIGHWAY
Summary
Encodes a nuclear-localized transcriptional activator with weak sequence similarity to basic helix-loop-helix(bHLH)-domain proteins. It promotes the production of stele cells in root meristems and is required to establish and maintain the normal vascular cell number and pattern in primary and lateral roots.
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Genomic context

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See LHW in Genome Data Viewer
Location:
chromosome: 2
Exon count:
9
Sequence:
Chromosome: 2; NC_003071.7 (11650358..11654143)

Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene BEL1-like homeodomain 5 Neighboring gene Pentatricopeptide repeat (PPR) superfamily protein Neighboring gene aluminum activated malate transporter family protein Neighboring gene CLAVATA3

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Auxin-associated initiation of vascular cell differentiation by LONESOME HIGHWAY. Ohashi-Ito K, et al. Development, 2013 Feb. PMID 23362345
  2. LONESOME HIGHWAY-TARGET OF MONOPTEROS5 transcription factor complex promotes a predifferentiation state for xylem vessel differentiation in the root apical meristem by inducing the expression of VASCULAR-RELATED NAC-DOMAIN genes. Ohashi-Ito K, et al. New Phytol, 2024 May. PMID 38462819
  3. Vascular transcription factors guide plant epidermal responses to limiting phosphate conditions. Wendrich JR, et al. Science, 2020 Nov 13. PMID 32943451, Free PMC Article
  4. Evolution of vascular plants through redeployment of ancient developmental regulators. Lu KJ, et al. Proc Natl Acad Sci U S A, 2020 Jan 7. PMID 31874927, Free PMC Article
  5. An atypical bHLH transcription factor regulates early xylem development downstream of auxin. Ohashi-Ito K, et al. Plant Cell Physiol, 2013 Mar. PMID 23359424

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. LONESOME HIGHWAY-TARGET OF MONOPTEROS5 transcription factor complex promotes a predifferentiation state for xylem vessel differentiation in the root apical meristem by inducing the expression of VASCULAR-RELATED NAC-DOMAIN genes.
    Title: LONESOME HIGHWAY-TARGET OF MONOPTEROS5 transcription factor complex promotes a predifferentiation state for xylem vessel differentiation in the root apical meristem by inducing the expression of VASCULAR-RELATED NAC-DOMAIN genes.
  2. Vascular transcription factors guide plant epidermal responses to limiting phosphate conditions.
    Title: Vascular transcription factors guide plant epidermal responses to limiting phosphate conditions.
  3. Study revealed the evolutionary trajectory for the heterodimeric TMO5/LHW transcription factor complex, which is rate-limiting for vascular cell proliferation in Arabidopsis thaliana. Both regulators have origins predating vascular tissue emergence, and even terrestrialization. TMO5 evolved its modern function, including dimerization with LHW, at the origin of land plants.
    Title: Evolution of vascular plants through redeployment of ancient developmental regulators.
  4. LHW functions as a key regulator to initiate vascular cell differentiation in association with auxin regulation.
    Title: Auxin-associated initiation of vascular cell differentiation by LONESOME HIGHWAY.
  5. LHW is nuclear-localized and is expressed in the root meristems, where we hypothesize it acts independently of other known root-patterning genes to promote the production of stele cells. [Lonesome Highway] [LHW]
    Title: Regulation of the Arabidopsis root vascular initial population by LONESOME HIGHWAY.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Miscellaneous features

  • Loc: 11650592-11650696 AT2G27230.uORF1
NM_001036353.1
NM_128281.2

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables protein homodimerization activity IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within maintenance of root meristem identity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of DNA-templated transcription IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within regulation of DNA-templated transcription TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within root development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within stele development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within xylem development IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
transcription factor-like protein
NP_001031430.1
  • LONESOME HIGHWAY (LHW); CONTAINS InterPro DOMAIN/s: Helix-loop-helix DNA-binding domain (InterPro:IPR001092); BEST Arabidopsis thaliana protein match is: Serine/threonine-protein kinase WNK (With No Lysine)-related (TAIR:AT1G64625.3); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
NP_565640.1
  • LONESOME HIGHWAY (LHW); CONTAINS InterPro DOMAIN/s: Helix-loop-helix DNA-binding domain (InterPro:IPR001092); BEST Arabidopsis thaliana protein match is: Serine/threonine-protein kinase WNK (With No Lysine)-related (TAIR:AT1G64625.3); Has 448 Blast hits to 377 proteins in 66 species: Archae - 0; Bacteria - 0; Metazoa - 0; Fungi - 0; Plants - 446; Viruses - 0; Other Eukaryotes - 2 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003071.7 Reference assembly

    Range
    11650358..11654143
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_128281.2 → NP_565640.1  transcription factor-like protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_565640.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B9DGI1, Q0WMN8, Q9XIN0
    UniProtKB/TrEMBL
    A0A178VXD3, A0A5S9X1X6, A0A7G2EC48
    Conserved Domains (2) summary
    cd18915
    Location:459 → 529
    bHLH_AtLHW_like; basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana protein LONESOME HIGHWAY (LHW) and similar proteins
    pfam14215
    Location:5 → 159
    bHLH-MYC_N; bHLH-MYC and R2R3-MYB transcription factors N-terminal

  2. NM_001036353.1 → NP_001031430.1  transcription factor-like protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001031430.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B9DGI1, Q0WMN8, Q9XIN0
    UniProtKB/TrEMBL
    A0A178VXD3, A0A5S9X1X6, A0A7G2EC48
    Conserved Domains (2) summary
    cd18915
    Location:459 → 529
    bHLH_AtLHW_like; basic helix-loop-helix (bHLH) domain found in Arabidopsis thaliana protein LONESOME HIGHWAY (LHW) and similar proteins
    pfam14215
    Location:5 → 159
    bHLH-MYC_N; bHLH-MYC and R2R3-MYB transcription factors N-terminal
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9XIN0.1

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