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AGL61 AGAMOUS-like 61 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 817021, updated on 18-Sep-2024

Summary

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Official Symbol
AGL61
Official Full Name
AGAMOUS-like 61
Primary source
TAIR:AT2G24840
Locus tag
AT2G24840
See related
Araport:AT2G24840
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
AGAMOUS-like 61; DIA; DIANA; F27C12.24; F27C12_24
Summary
Encodes a member of the Agamous-like family of transcription factors. Localized to the nucleus in the central cell and endosperm of the female gametophyte. Loss of function mutations show reduced female fertility. Fifty percent of ovules have defective central cells with abnormal morphology and patterns of gene expression. Upon fertilization 50% of seeds abort. Using yeast two hybrid assays AGL61 was shown to interact with AGL80, another MADS box gene with similar defects in ovule development. These data suggest that AGL61 and 80 together are required for proper differentiation of the central cell.
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Genomic context

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See AGL61 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
1
Sequence:
Chromosome: 2; NC_003071.7 (10581069..10582015)

Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene translocon at the inner envelope membrane of chloroplasts 55-II Neighboring gene ncRNA Neighboring gene zinc finger (CCCH-type) family protein / D111/G-patch domain-containing protein Neighboring gene tyrosine aminotransferase 3 Neighboring gene DnaJ/Hsp40 cysteine-rich domain superfamily protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The MADS domain protein DIANA acts together with AGAMOUS-LIKE80 to specify the central cell in Arabidopsis ovules. Bemer M, et al. Plant Cell, 2008 Aug. PMID 18713950, Free PMC Article
  2. AGL61 interacts with AGL80 and is required for central cell development in Arabidopsis. Steffen JG, et al. Plant Physiol, 2008 Sep. PMID 18599653, Free PMC Article
  3. Molecular and phylogenetic analyses of the complete MADS-box transcription factor family in Arabidopsis: new openings to the MADS world. Parenicová L, et al. Plant Cell, 2003 Jul. PMID 12837945, Free PMC Article
  4. Differential binding of calmodulin-related proteins to their targets revealed through high-density Arabidopsis protein microarrays. Popescu SC, et al. Proc Natl Acad Sci U S A, 2007 Mar 13. PMID 17360592, Free PMC Article
  5. Arabidopsis transcription factors: genome-wide comparative analysis among eukaryotes. Riechmann JL, et al. Science, 2000 Dec 15. PMID 11118137

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data show that AGL61 and AGL80 appear to function together to differentiate the central cell in Arabidopsis. Data renamed AGL61 DIANA, after the virginal Roman goddess of the hunt.
    Title: The MADS domain protein DIANA acts together with AGAMOUS-LIKE80 to specify the central cell in Arabidopsis ovules.
  2. controls the expression of downstream genes during central cell development
    Title: AGL61 interacts with AGL80 and is required for central cell development in Arabidopsis.
  3. DIANA (AGL61) forms a complex with AGL80 to specify the central cell in Arabidopsis ovules. [AGL61] [DIANA]
    Title: The MADS domain protein DIANA acts together with AGAMOUS-LIKE80 to specify the central cell in Arabidopsis ovules.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_179727.5

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables DNA-binding transcription factor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein dimerization activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within embryo sac central cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  
located_in polar nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
AGAMOUS-like 61
NP_850058.1
  • AGAMOUS-like 61 (AGL61); CONTAINS InterPro DOMAIN/s: Transcription factor, MADS-box (InterPro:IPR002100); BEST Arabidopsis thaliana protein match is: AGAMOUS-like 62 (TAIR:AT5G60440.1); Has 5781 Blast hits to 5781 proteins in 683 species: Archae - 0; Bacteria - 0; Metazoa - 624; Fungi - 302; Plants - 4788; Viruses - 0; Other Eukaryotes - 67 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003071.7 Reference assembly

    Range
    10581069..10582015
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_179727.5 → NP_850058.1  AGAMOUS-like 61 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_850058.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q4PSU4, Q9SK48
    Conserved Domains (1) summary
    cd00265
    Location:63 → 130
    MADS_MEF2_like; MEF2 (myocyte enhancer factor 2)-like/Type II subfamily of MADS ( MCM1, Agamous, Deficiens, and SRF (serum response factor) box family of eukaryotic transcriptional regulators. Binds DNA and exists as hetero and homo-dimers. Differs from SRF-like/Type I ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q4PSU4.1

Gene LinkOut

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