U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

GRF1 growth-regulating factor 1 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 816815, updated on 18-Sep-2024

Summary

Go to the top of the page Help
Official Symbol
GRF1
Official Full Name
growth-regulating factor 1
Primary source
TAIR:AT2G22840
Locus tag
AT2G22840
See related
Araport:AT2G22840
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
AtGRF1; growth-regulating factor 1; T20K9.5; T20K9_5
Summary
Growth regulating factor encoding transcription activator. One of the nine members of a GRF gene family, containing nuclear targeting domain. Mutants result in smaller leaves indicating the role of the gene in leaf development. Expressed in root, shoot and flower
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See GRF1 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
4
Sequence:
Chromosome: 2; NC_003071.7 (9728480..9731301)

Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene ncRNA Neighboring gene squalene epoxidase 2 Neighboring gene basic leucine-zipper 6 Neighboring gene ncRNA Neighboring gene phytosulfokine 2 precursor

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. GROWTH-REGULATING FACTORS Interact with DELLAs and Regulate Growth in Cold Stress. Lantzouni O, et al. Plant Cell, 2020 Apr. PMID 32060178, Free PMC Article
  2. The Arabidopsis microRNA396-GRF1/GRF3 regulatory module acts as a developmental regulator in the reprogramming of root cells during cyst nematode infection. Hewezi T, et al. Plant Physiol, 2012 May. PMID 22419826, Free PMC Article
  3. A transcriptional coactivator, AtGIF1, is involved in regulating leaf growth and morphology in Arabidopsis. Kim JH, et al. Proc Natl Acad Sci U S A, 2004 Sep 7. PMID 15326298, Free PMC Article
  4. The AtGRF family of putative transcription factors is involved in leaf and cotyledon growth in Arabidopsis. Kim JH, et al. Plant J, 2003 Oct. PMID 12974814
  5. Molecular mechanism of microRNA396 mediating pistil development in Arabidopsis. Liang G, et al. Plant Physiol, 2014 Jan. PMID 24285851, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. GRF1 and GRF3 are posttranscriptionally regulated by miR396 during nematode infection.
    Title: The Arabidopsis microRNA396-GRF1/GRF3 regulatory module acts as a developmental regulator in the reprogramming of root cells during cyst nematode infection.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help
NM_127849.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transcription cis-regulatory region binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within glucosinolate metabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within leaf development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within regulation of nematode larval development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within response to cold IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within response to gibberellin IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within response to nematode IEP
Inferred from Expression Pattern
more info
 PubMed 
acts_upstream_of_or_within root development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 

General protein information

Go to the top of the page Help
Preferred Names
growth-regulating factor 1
NP_179869.1
  • growth-regulating factor 1 (GRF1); CONTAINS InterPro DOMAIN/s: Glutamine-Leucine-Glutamine, QLQ (InterPro:IPR014978), WRC (InterPro:IPR014977); BEST Arabidopsis thaliana protein match is: growth-regulating factor 2 (TAIR:AT4G37740.1); Has 714 Blast hits to 669 proteins in 68 species: Archae - 0; Bacteria - 24; Metazoa - 65; Fungi - 20; Plants - 548; Viruses - 4; Other Eukaryotes - 53 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003071.7 Reference assembly

    Range
    9728480..9731301
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_127849.4 → NP_179869.1  growth-regulating factor 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_179869.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O81001
    UniProtKB/TrEMBL
    A0A654F0B7
    Conserved Domains (2) summary
    pfam08879
    Location:197 → 238
    WRC; WRC
    pfam08880
    Location:133 → 159
    QLQ; QLQ
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O81001.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools