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GEM GRAM domain family protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 816780, updated on 18-Sep-2024

Summary

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Official Symbol
GEM
Official Full Name
GRAM domain family protein
Primary source
TAIR:AT2G22475
Locus tag
AT2G22475
See related
Araport:AT2G22475
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
GL2-EXPRESSION MODULATOR
Summary
Encodes GL2-expression modulator (GEM). Involved in the spatial control of cell division, patterning and differentiation of Arabidopsis root epidermal cells. GEM interacts with CDT1, a DNA replication protein and TTG1 (TRANSPARENT TESTA GLABRA1), a WD40-repeat protein involved in GL2-dependent cell fate decision. GEM seems to participate in the maintenance of a repressor histone H3 epigenetics status of the GL2 and CPC (CAPRICE) promoters.
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Genomic context

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See GEM in Genome Data Viewer
Location:
chromosome: 2
Exon count:
4
Sequence:
Chromosome: 2; NC_003071.7 (9541128..9545038)

Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene MIZU-KUSSEI-like protein (Protein of unknown function, DUF617) Neighboring gene uncharacterized protein Neighboring gene arabinogalactan protein 2 Neighboring gene phosphofructokinase 5 Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. GL2 EXPRESSION MODULATOR, a plant specific protein phosphatase one interactor that binds phosphoinositides. Templeton GW, et al. Biochem Biophys Res Commun, 2020 Jul 30. PMID 32513542
  2. GEM, a member of the GRAM domain family of proteins, is part of the ABA signaling pathway. Mauri N, et al. Sci Rep, 2016 Mar 4. PMID 26939893, Free PMC Article
  3. Pathways for epidermal cell differentiation via the homeobox gene GLABRA2: update on the roles of the classic regulator. Lin Q, et al. J Integr Plant Biol, 2012 Oct. PMID 22943441
  4. Identification of a regulatory subunit of protein phosphatase 1 which mediates blue light signaling for stomatal opening. Takemiya A, et al. Plant Cell Physiol, 2013 Jan. PMID 22585556
  5. A chromatin link that couples cell division to root epidermis patterning in Arabidopsis. Caro E, et al. Nature, 2007 May 10. PMID 17450124

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. GL2 EXPRESSION MODULATOR, a plant specific protein phosphatase one interactor that binds phosphoinositides.
    Title: GL2 EXPRESSION MODULATOR, a plant specific protein phosphatase one interactor that binds phosphoinositides.
  2. These data suggest that GEM is an abscisic acid-responsive protein that may function downstream of ABI5 as part of the abscisic acid signaling pathway.
    Title: GEM, a member of the GRAM domain family of proteins, is part of the ABA signaling pathway.
  3. GL2 directly regulates genes with various hierarchies in epidermal cell differentiation pathways.
    Title: Pathways for epidermal cell differentiation via the homeobox gene GLABRA2: update on the roles of the classic regulator.
  4. GEM participates in the maintenance of the repressor histone H3K9 methylation status of root patterning genes, providing a link between cell division, fate and differentiation during Arabidopsis root development [GEM]
    Title: A chromatin link that couples cell division to root epidermis patterning in Arabidopsis.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_127813.3
NM_201781.1

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within epigenetic regulation of gene expression IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within regulation of epidermal cell division IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within root hair cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within trichome differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus ISM
Inferred from Sequence Model
more info
  
located_in vacuole HDA PubMed 

General protein information

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Preferred Names
GRAM domain family protein
NP_565538.1
  • GL2-EXPRESSION MODULATOR (GEM); CONTAINS InterPro DOMAIN/s: GRAM (InterPro:IPR004182); BEST Arabidopsis thaliana protein match is: GRAM domain family protein (TAIR:AT4G40100.1); Has 360 Blast hits to 359 proteins in 24 species: Archae - 0; Bacteria - 0; Metazoa - 1; Fungi - 0; Plants - 359; Viruses - 0; Other Eukaryotes - 0 (source: NCBI BLink).
NP_973510.1
  • GL2-EXPRESSION MODULATOR (GEM); CONTAINS InterPro DOMAIN/s: GRAM (InterPro:IPR004182); BEST Arabidopsis thaliana protein match is: GRAM domain family protein (TAIR:AT4G40100.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003071.7 Reference assembly

    Range
    9541128..9545038
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_127813.3 → NP_565538.1  GRAM domain family protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_565538.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q3EBW7, Q8GWY9, Q8LBI8, Q8S8F8
    UniProtKB/TrEMBL
    A0A178VMY6, A0A5S9X075, A0A654EV35
    Conserved Domains (1) summary
    cd13222
    Location:186 → 292
    PH-GRAM_GEM; GLABRA 2 expression modulator (GEM) Pleckstrin Homology-Glucosyltransferases, Rab-like GTPase activators and Myotubularins (PH-GRAM) domain

  2. NM_201781.1 → NP_973510.1  GRAM domain family protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_973510.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178VMY6
    Conserved Domains (1) summary
    cl17171
    Location:186 → 242
    PH-like; Pleckstrin homology-like domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8S8F8.1

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