Itpka inositol-trisphosphate 3-kinase A [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Itpkaprovided by RGD
Official Full Name: inositol-trisphosphate 3-kinase Aprovided by RGD
Primary source: RGD:619950
See related: EnsemblRapid:ENSRNOG00000005284 AllianceGenome:RGD:619950
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables calcium/calmodulin-dependent protein kinase activity; inositol-1,4,5-trisphosphate 3-kinase activity; and small GTPase binding activity. Involved in modification of postsynaptic actin cytoskeleton. Acts upstream of or within actin cytoskeleton organization; dendritic spine maintenance; and positive regulation of dendritic spine morphogenesis. Located in dendritic spine. Is active in glutamatergic synapse and postsynaptic actin cytoskeleton. Orthologous to human ITPKA (inositol-trisphosphate 3-kinase A). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Brain (RPKM 127.2), Testes (RPKM 126.0) and 3 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 3q35

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	3	NC_086021.1 (127179841..127188405)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	3	NC_051338.1 (106726036..106734601)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	3	NC_005102.4 (111545007..111553605)

Chromosome 3 - NC_086021.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

IP3 3-kinase opposes NGF driven neurite outgrowth
Title: IP3 3-kinase opposes NGF driven neurite outgrowth.
Data show that protein kinse A (PKA) phosphorylated Ser-119 within inositol 1,4,5-trisphosphate 3-kinase A (IP(3)K-A), leading to a significant reduction of microtubule binding affinity.
Title: Inositol 1,4,5-trisphosphate 3-kinase A is a novel microtubule-associated protein: PKA-dependent phosphoregulation of microtubule binding affinity.
These results suggest that, in addition to its ability to regulate intracellular Ca(2+) via Ins(1,4,5)P(3) metabolism, ITPKA regulates structural plasticity.
Title: Neuronal IP3 3-kinase is an F-actin-bundling protein: role in dendritic targeting and regulation of spine morphology.
these results suggest that oscillations in InsP(3) concentration due to Ca(2+)-stimulated InsP(3) catabolism do not play a major role for the oscillations in Ca(2+) concentration.
Title: Ca2+ oscillations in hepatocytes do not require the modulation of InsP3 3-kinase activity by Ca2+.
the large majority of InsP3R3 channels free to diffuse throughout the endoplasmic reticulum, at rates that are comparable with those measured for other polytopic ER integral membrane proteins
Title: Translational mobility of the type 3 inositol 1,4,5-trisphosphate receptor Ca2+ release channel in endoplasmic reticulum membrane.
plays a role in the processing of spatial memory, most likely by regulating the calcium signaling in the dendritic spines of hippocampal formation
Title: Spatial learning enhances the expression of inositol 1,4,5-trisphosphate 3-kinase A in the hippocampal formation of rat.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH130923 (e-PCR)
- UniSTS:214207

BE106366 (e-PCR)
- UniSTS:246241

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables calcium/calmodulin-dependent protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables calmodulin binding	IEA Inferred from Electronic Annotation more info
enables inositol hexakisphosphate kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables inositol-1,4,5-trisphosphate 3-kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables inositol-1,4,5-trisphosphate 3-kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables inositol-1,4,5-trisphosphate 3-kinase activity	ISO Inferred from Sequence Orthology more info
enables small GTPase binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within actin cytoskeleton organization	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to calcium ion	ISO Inferred from Sequence Orthology more info
involved_in cellular response to calcium ion	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within dendritic spine maintenance	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within inositol metabolic process	ISO Inferred from Sequence Orthology more info
involved_in inositol phosphate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in modification of postsynaptic actin cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
involved_in modification of postsynaptic actin cytoskeleton	IEP Inferred from Expression Pattern more info	PubMed
involved_in modification of postsynaptic actin cytoskeleton	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphatidylinositol phosphate biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in phosphatidylinositol phosphate biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylinositol phosphate biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within positive regulation of dendritic spine morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of synaptic plasticity	ISO Inferred from Sequence Orthology more info
involved_in response to calcium ion	ISO Inferred from Sequence Orthology more info
involved_in response to calcium ion	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in cytoskeleton	ISS Inferred from Sequence or Structural Similarity more info
located_in dendritic spine	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
is_active_in postsynaptic actin cytoskeleton	IDA Inferred from Direct Assay more info	PubMed
is_active_in postsynaptic actin cytoskeleton	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: inositol-trisphosphate 3-kinase A

Names: IP3 3-kinase A; IP3K A; inositol 1,4,5-triphosphate 3-kinase; inositol 1,4,5-trisphosphate 3-kinase A; inositol 145-triphosphate 3-kinase; insP 3-kinase A

NP_112307.2

EC 2.7.1.127

XP_038961845.1

EC 2.7.1.127

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_031045.2 → NP_112307.2 inositol-trisphosphate 3-kinase A

See identical proteins and their annotated locations for NP_112307.2

Status: VALIDATED

Source sequence(s)

BQ204027, JAXUCZ010000003, M29787

UniProtKB/Swiss-Prot

P17105

UniProtKB/TrEMBL

A6HPH2, A6HPH3

Related

ENSRNOP00000007247.1, ENSRNOT00000007247.5

Conserved Domains (1) summary

pfam03770
Location:243 → 453

IPK; Inositol polyphosphate kinase

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086021.1 Reference GRCr8

Range

127179841..127188405

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039105917.2 → XP_038961845.1 inositol-trisphosphate 3-kinase A isoform X1

Conserved Domains (1) summary

pfam03770
Location:116 → 326

IPK; Inositol polyphosphate kinase