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MIPS2 myo-inositol-1-phosphate synthase 2 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 816757, updated on 18-Sep-2024

Summary

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Official Symbol
MIPS2
Official Full Name
myo-inositol-1-phosphate synthase 2
Primary source
TAIR:AT2G22240
Locus tag
AT2G22240
See related
Araport:AT2G22240
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ATIPS2; ATMIPS1; ATMIPS2; INOSITOL 3-PHOSPHATE SYNTHASE 2; MIPS1; myo-inositol-1-phosphate synthase 1; myo-inositol-1-phosphate synthase 2; MYO-INOSITOL-1-PHOSTPATE SYNTHASE 1; MYO-INOSITOL-1-PHOSTPATE SYNTHASE 2
Summary
** Referred to as MIPS1 in Mitsuhashi et al 2008. Myo-inositol-1-phosphate synthase isoform 2. Expressed in leaf, root and silique. Immunolocalization experiments with an antibody recognizing MIPS1, MIPS2, and MIPS3 showed endosperm localization.
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Genomic context

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See MIPS2 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
7
Sequence:
Chromosome: 2; NC_003071.7 (9451605..9454300, complement)

Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene tRNA-Ile Neighboring gene Thioesterase superfamily protein Neighboring gene uncharacterized protein Neighboring gene aspartate aminotransferase Neighboring gene oxidoreductase, 2OG-Fe(II) oxygenase family protein Neighboring gene hematological/neurological-like protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Influence of cytokinins on the expression of phosphate starvation responsive genes in Arabidopsis. Martín AC, et al. Plant J, 2000 Dec. PMID 11123795
  2. Co-suppression of AtMIPS demonstrates cooperation of MIPS1, MIPS2 and MIPS3 in maintaining myo-inositol synthesis. Fleet CM, et al. Plant Mol Biol, 2018 Jun. PMID 29777485
  3. The Arabidopsis thaliana Myo-inositol 1-phosphate synthase1 gene is required for Myo-inositol synthesis and suppression of cell death. Donahue JL, et al. Plant Cell, 2010 Mar. PMID 20215587, Free PMC Article
  4. A role for inositol hexakisphosphate in the maintenance of basal resistance to plant pathogens. Murphy AM, et al. Plant J, 2008 Nov. PMID 18643983
  5. D-myo-inositol-3-phosphate affects phosphatidylinositol-mediated endomembrane function in Arabidopsis and is essential for auxin-regulated embryogenesis. Luo Y, et al. Plant Cell, 2011 Apr. PMID 21505066, Free PMC Article

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. works with MIPS1 AND MIPS3 to impact the overall synthesis of myo-inositol and overall inositol homeostasis
    Title: Co-suppression of AtMIPS demonstrates cooperation of MIPS1, MIPS2 and MIPS3 in maintaining myo-inositol synthesis.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_001335785.1
NM_127790.4
NM_201780.2

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables inositol-3-phosphate synthase activity IEA
Inferred from Electronic Annotation
more info
  
enables inositol-3-phosphate synthase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within cellular response to phosphate starvation TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within defense response to bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within defense response to fungus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within defense response to virus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within embryo development ending in seed dormancy IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in inositol biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within myo-inositol hexakisphosphate biosynthetic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phospholipid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within response to auxin TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
myo-inositol-1-phosphate synthase 2
NP_179812.1
  • myo-inositol-1-phosphate synthase 2 (MIPS2); CONTAINS InterPro DOMAIN/s: Myo-inositol-1-phosphate synthase (InterPro:IPR002587), Myo-inositol-1-phosphate synthase, GAPDH-like (InterPro:IPR013021), NAD(P)-binding domain (InterPro:IPR016040); BEST Arabidopsis thaliana protein match is: myo-inositol-1-phosphate synthase 1 (TAIR:AT4G39800.1); Has 1859 Blast hits to 1855 proteins in 512 species: Archae - 101; Bacteria - 453; Metazoa - 126; Fungi - 158; Plants - 764; Viruses - 0; Other Eukaryotes - 257 (source: NCBI BLink).
NP_973509.1
  • myo-inositol-1-phosphate synthase 2 (MIPS2); CONTAINS InterPro DOMAIN/s: Myo-inositol-1-phosphate synthase (InterPro:IPR002587), Myo-inositol-1-phosphate synthase, GAPDH-like (InterPro:IPR013021), NAD(P)-binding domain (InterPro:IPR016040); BEST Arabidopsis thaliana protein match is: myo-inositol-1-phosphate synthase 1 (TAIR:AT4G39800.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003071.7 Reference assembly

    Range
    9451605..9454300 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_127790.4 → NP_179812.1  myo-inositol-1-phosphate synthase 2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_179812.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q38862, Q9SIE2
    UniProtKB/TrEMBL
    A0A178VS65, A0A5S9X0D0, A0A654EV50
    Conserved Domains (1) summary
    PLN02438
    Location:1 → 510
    PLN02438; inositol-3-phosphate synthase

  2. NM_001335785.1 → NP_001324779.1  myo-inositol-1-phosphate synthase 2 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A178VS65, A0A1P8B151

  3. NM_201780.2 → NP_973509.1  myo-inositol-1-phosphate synthase 2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_973509.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    F4IIN3
    Conserved Domains (1) summary
    cl00554
    Location:1 → 380
    NAD_binding_5; Myo-inositol-1-phosphate synthase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q38862.2

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