HK1 histidine kinase 1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: HK1
Official Full Name: histidine kinase 1
Primary source: TAIR:AT2G17820
Locus tag: AT2G17820
See related: Araport:AT2G17820
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: AHK1; ATHK1; histidine kinase 1; T13L16.16; T13L16_16
Summary: Encodes a member of the histidine kinase family.
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Genomic context

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See HK1 in Genome Data Viewer

Location:: chromosome: 2

Exon count:: 13

Sequence:: Chromosome: 2; NC_003071.7 (7742870..7748502, complement)

Chromosome 2 - NC_003071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

results show that de novo biosynthesis of abscisic acid, via up-regulation of the rate-limiting NCED3 gene, can be triggered by changes in leaf turgor; AHK1 does not function as the critical turgor-sensing receptor
Title: Up-regulation of NCED3 and ABA biosynthesis occur within minutes of a decrease in leaf turgor but AHK1 is not required.
Data indicate that the unimpaired growth, abscisic acid (ABA), proline, and solute accumulation of ahk1 mutants at low psi(w) suggest that AHK1 may not be the main plant osmosensor required for low water potential psi(w) tolerance.
Title: Role of the putative osmosensor Arabidopsis histidine kinase1 in dehydration avoidance and low-water-potential response.
Since overexpression of ATHK1 results in increased water stress tolerance, our observations suggest a new top-down route to increasing drought resistance via receptor-mediated increases in sensing water status
Title: Analysis of the Arabidopsis histidine kinase ATHK1 reveals a connection between vegetative osmotic stress sensing and seed maturation.
AHK1 plays important roles in plant growth because the ahk1 ahk2 ahk3 triple mutant showed further reduced growth.
Title: Functional analysis of AHK1/ATHK1 and cytokinin receptor histidine kinases in response to abscisic acid, drought, and salt stress in Arabidopsis.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_127335.2

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables histidine phosphotransfer kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables osmosensor activity	IGI Inferred from Genetic Interaction more info	PubMed
enables osmosensor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables phosphorelay sensor kinase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein histidine kinase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within response to osmotic stress	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to water deprivation	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to water deprivation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within seed maturation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within stomatal complex patterning	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	ISM Inferred from Sequence Model more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: histidine kinase 1

NP_565424.1

histidine kinase 1 (HK1); FUNCTIONS IN: osmosensor activity, protein histidine kinase activity, histidine phosphotransfer kinase activity; INVOLVED IN: response to water deprivation, seed maturation, response to osmotic stress; LOCATED IN: membrane; EXPRESSED IN: 19 plant structures; EXPRESSED DURING: 12 growth stages; CONTAINS InterPro DOMAIN/s: Signal transduction histidine kinase, homodimeric (InterPro:IPR009082), Signal transduction histidine kinase, core (InterPro:IPR005467), ATPase-like, ATP-binding domain (InterPro:IPR003594), CheY-like (InterPro:IPR011006), Signal transduction response regulator, receiver domain (InterPro:IPR001789), Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor domain (InterPro:IPR003661), Signal transduction histidine kinase-related protein, C-terminal (InterPro:IPR004358); BEST Arabidopsis thaliana protein match is: Signal transduction histidine kinase (TAIR:AT2G47430.1); Has 149976 Blast hits to 132540 proteins in 3044 species: Archae - 792; Bacteria - 133304; Metazoa - 35; Fungi - 2288; Plants - 2106; Viruses - 27; Other Eukaryotes - 11424 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003071.7 Reference assembly

Range

7742870..7748502 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_127335.2 → NP_565424.1 histidine kinase 1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_565424.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9SXL4

UniProtKB/TrEMBL

A0A178VSH6, A0A5S9WYZ3

Conserved Domains (3) summary

smart00387
Location:611 → 762

HATPase_c; Histidine kinase-like ATPases

smart00388
Location:499 → 564

HisKA; His Kinase A (phosphoacceptor) domain

COG0784
Location:1041 → 1195

CheY; CheY chemotaxis protein or a CheY-like REC (receiver) domain [Signal transduction mechanisms]