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cldn1 claudin 1 [ Danio rerio (zebrafish) ]

Gene ID: 81590, updated on 2-Nov-2024

Summary

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Official Symbol
cldn1provided by ZNC
Official Full Name
claudin 1provided by ZNC
Primary source
ZFIN:ZDB-GENE-010328-11
See related
AllianceGenome:ZFIN:ZDB-GENE-010328-11
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
cldn19
Summary
Predicted to enable structural molecule activity. Predicted to be involved in bicellular tight junction assembly and cell adhesion. Predicted to be located in anchoring junction and membrane. Predicted to be active in bicellular tight junction and plasma membrane. Is expressed in eye; female organism; gill; integument; and posterior intestine. Human ortholog(s) of this gene implicated in Crohn's disease and atopic dermatitis. Orthologous to human CLDN1 (claudin 1). [provided by Alliance of Genome Resources, Nov 2024]
Annotation information
Annotation category: partial on reference assembly
Orthologs
all
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Genomic context

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See cldn1 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
3
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (68788..71962)
105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (45314..48488, complement)

Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene tensin-3 Neighboring gene zgc:153913 Neighboring gene NAD-dependent protein deacylase sirtuin-5, mitochondrial Neighboring gene phosphatase and actin regulator 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. STW 5 Herbal Preparation Modulates Wnt3a and Claudin 1 Gene Expression in Zebrafish IBS-like Model. Piccione M, et al. Pharmaceuticals (Basel), 2021 Nov 28. PMID 34959635, Free PMC Article
  2. Reactive oxygen species participate in liver function recovery during compensatory growth in zebrafish (Danio rerio). Jia J, et al. Biochem Biophys Res Commun, 2018 May 5. PMID 29574160
  3. A novel transgenic zebrafish model for blood-brain and blood-retinal barrier development. Xie J, et al. BMC Dev Biol, 2010 Jul 23. PMID 20653957, Free PMC Article
  4. Pediococcus pentosaceus PR-1 modulates high-fat-died-induced alterations in gut microbiota, inflammation, and lipid metabolism in zebrafish. Liu Y, et al. Front Nutr, 2023. PMID 36819708, Free PMC Article
  5. Exogenous GDF9 but not Activin A, BMP15 or TGFβ alters tight junction protein transcript abundance in zebrafish ovarian follicles. Clelland ES, et al. Gen Comp Endocrinol, 2011 Apr 1. PMID 21291886

See all (22) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables structural molecule activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in bicellular tight junction assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell adhesion IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
  
is_active_in bicellular tight junction IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in bicellular tight junction IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
claudin-1
Names
claudin 19

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_131770.1 → NP_571845.1  claudin-1 precursor

    See identical proteins and their annotated locations for NP_571845.1

    Status: PROVISIONAL

    Source sequence(s)
    AF359436
    UniProtKB/TrEMBL
    Q90XQ8
    Conserved Domains (1) summary
    cl21598
    Location:24 → 182
    PMP22_Claudin; PMP-22/EMP/MP20/Claudin family

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007113.7 Reference GRCz11 Primary Assembly

    Range
    68788..71962
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version

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