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NAD-ME1 NAD-dependent malic enzyme 1 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 815842, updated on 18-Sep-2024

Summary

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Official Symbol
NAD-ME1
Official Full Name
NAD-dependent malic enzyme 1
Primary source
TAIR:AT2G13560
Locus tag
AT2G13560
See related
Araport:AT2G13560
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
NAD-dependent malic enzyme 1; T10F5.10; T10F5_10
Summary
Encodes an NAD-dependent malic enzyme (NAD-ME) that does not act on oxaloacetate, indicating that it belongs to EC 1.1.1.39. It is a member of the alpha family of NAD-MEs in plants. It appears to function as a homodimer or as a heterodimer with the beta-type NAD-ME2 (At4g00570). NAD-ME1 transcript and protein levels are higher during the night than during the day.
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Genomic context

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See NAD-ME1 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
19
Sequence:
Chromosome: 2; NC_003071.7 (5649928..5655320)

Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene uncharacterized protein Neighboring gene nuclear factor Y, subunit B7 Neighboring gene miscRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Fine mapping identifies NAD-ME1 as a candidate underlying a major locus controlling temporal variation in primary and specialized metabolism in Arabidopsis. Francisco M, et al. Plant J, 2021 Apr. PMID 33523525
  2. Three different and tissue-specific NAD-malic enzymes generated by alternative subunit association in Arabidopsis thaliana. Tronconi MA, et al. J Biol Chem, 2010 Apr 16. PMID 20133948, Free PMC Article
  3. Arabidopsis NAD-malic enzyme functions as a homodimer and heterodimer and has a major impact on nocturnal metabolism. Tronconi MA, et al. Plant Physiol, 2008 Apr. PMID 18223148, Free PMC Article
  4. Analysis of the soluble ATP-binding proteome of plant mitochondria identifies new proteins and nucleotide triphosphate interactions within the matrix. Ito J, et al. J Proteome Res, 2006 Dec. PMID 17137349
  5. The Extra-Pathway Interactome of the TCA Cycle: Expected and Unexpected Metabolic Interactions. Zhang Y, et al. Plant Physiol, 2018 Jul. PMID 29794018, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Fine mapping identifies NAD-ME1 as a candidate underlying a major locus controlling temporal variation in primary and specialized metabolism in Arabidopsis.
    Title: Fine mapping identifies NAD-ME1 as a candidate underlying a major locus controlling temporal variation in primary and specialized metabolism in Arabidopsis.
  2. The characterization of recombinant NAD-ME1 and -2 indicated that both enzymes assemble as active homodimers; however, a heterodimeric enzyme (NAD-MEH) can also be detected by electrophoretic studies.
    Title: Three different and tissue-specific NAD-malic enzymes generated by alternative subunit association in Arabidopsis thaliana.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_126936.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables ATP binding HDA PubMed 
enables NAD binding IEA
Inferred from Electronic Annotation
more info
  
enables cobalt ion binding HDA PubMed 
enables malate dehydrogenase (decarboxylating) (NAD+) activity IDA
Inferred from Direct Assay
more info
 PubMed 
NOT enables oxaloacetate decarboxylase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein homodimerization activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein homodimerization activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding HDA PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within malate metabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 
located_in mitochondrion ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
NAD-dependent malic enzyme 1
NP_178980.1
  • NAD-dependent malic enzyme 1 (NAD-ME1); FUNCTIONS IN: in 7 functions; INVOLVED IN: response to salt stress, malate metabolic process; LOCATED IN: mitochondrion, chloroplast; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Malic enzyme, NAD-binding (InterPro:IPR012302), Malic oxidoreductase (InterPro:IPR001891), Malic enzyme, conserved site (InterPro:IPR015884), Malic enzyme, N-terminal (InterPro:IPR012301), NAD(P)-binding domain (InterPro:IPR016040); BEST Arabidopsis thaliana protein match is: NAD-dependent malic enzyme 2 (TAIR:AT4G00570.1); Has 9465 Blast hits to 9448 proteins in 2440 species: Archae - 143; Bacteria - 6328; Metazoa - 607; Fungi - 221; Plants - 457; Viruses - 0; Other Eukaryotes - 1709 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003071.7 Reference assembly

    Range
    5649928..5655320
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_126936.4 → NP_178980.1  NAD-dependent malic enzyme 1 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_178980.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9SIU0
    UniProtKB/TrEMBL
    A0A178VZ17, A0A5S9WY72
    Conserved Domains (1) summary
    PLN03129
    Location:25 → 619
    PLN03129; NADP-dependent malic enzyme; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9SIU0.1

Gene LinkOut

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