U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

TRIM11 tripartite motif containing 11 [ Homo sapiens (human) ]

Gene ID: 81559, updated on 3-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
TRIM11provided by HGNC
Official Full Name
tripartite motif containing 11provided by HGNC
Primary source
HGNC:HGNC:16281
See related
Ensembl:ENSG00000154370 MIM:607868; AllianceGenome:HGNC:16281
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BIA1; RNF92
Summary
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the nucleus and the cytoplasm. Its function has not been identified. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in bone marrow (RPKM 7.7), spleen (RPKM 6.4) and 25 other tissues See more
Orthologs
mouse all
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See TRIM11 in Genome Data Viewer
Location:
1q42.13
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (228393676..228406835, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (227582208..227595361, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (228581377..228594536, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF Neighboring gene uncharacterized LOC124904535 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:228503020-228503894 Neighboring gene Sharpr-MPRA regulatory region 4086 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:228538867-228539366 Neighboring gene uncharacterized LOC101927401 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:228555546-228556114 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:228556115-228556682 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:228557329-228557895 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:228557896-228558461 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2693 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:228578692-228579248 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:228579249-228579804 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:228587477-228588152 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:228589505-228590179 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1917 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1918 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1919 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2694 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:228595439-228596098 Neighboring gene uncharacterized LOC124904537 Neighboring gene microRNA 6742 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1920 Neighboring gene tripartite motif containing 17 Neighboring gene H3.4 histone, cluster member

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help
  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. TRIM11 stimulates the proliferation of gastric cancer through targeting CPEB3/EGFR axis. Luo N, et al. J BUON, 2020 Jul-Aug. PMID 33099959
  2. TRIM11 promotes cell proliferation of non-small cell lung cancer through the inhibition of ferroptosis by AMPK. Liang Z, et al. Clin Respir J, 2023 Oct. PMID 37604203, Free PMC Article
  3. TRIM11 Prevents and Reverses Protein Aggregation and Rescues a Mouse Model of Parkinson's Disease. Zhu G, et al. Cell Rep, 2020 Dec 1. PMID 33264628, Free PMC Article
  4. High expression of TRIM11 correlates with poor prognosis in patients with hepatocellular carcinoma. Chen Y, et al. Clin Res Hepatol Gastroenterol, 2017 Mar. PMID 28065743
  5. TRIM11 Upregulation Contributes to Proliferation, Invasion, and EMT of Hepatocellular Carcinoma Cells. Zhang Z, et al. Oncol Res, 2017 May 24. PMID 28244856, Free PMC Article

See all (72) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Tripartite Motif-containing Protein 11 Silencing Inhibits Proliferation and Glycolysis and Promotes Apoptosis of Esophageal Squamous Cell Carcinoma Cells by Inactivating Signal Transduction and Activation of Transcription Factor 3/c-Myc Signaling.
    Title: Tripartite Motif-containing Protein 11 Silencing Inhibits Proliferation and Glycolysis and Promotes Apoptosis of Esophageal Squamous Cell Carcinoma Cells by Inactivating Signal Transduction and Activation of Transcription Factor 3/c-Myc Signaling.
  2. TRIM11 attenuates Treg cell differentiation by p62-selective autophagic degradation of AIM2.
    Title: TRIM11 attenuates Treg cell differentiation by p62-selective autophagic degradation of AIM2.
  3. TRIM11 promotes cell proliferation of non-small cell lung cancer through the inhibition of ferroptosis by AMPK.
    Title: TRIM11 promotes cell proliferation of non-small cell lung cancer through the inhibition of ferroptosis by AMPK.
  4. TRIM11 protects against tauopathies and is down-regulated in Alzheimer's disease.
    Title: TRIM11 protects against tauopathies and is down-regulated in Alzheimer's disease.
  5. TRIM11 Posttranscriptionally Modulated by miR-5193 Facilitates Tumor Growth and Metastasis of Prostate Cancer.
    Title: TRIM11 Posttranscriptionally Modulated by miR-5193 Facilitates Tumor Growth and Metastasis of Prostate Cancer.
  6. TRIM11, a new target of p53, facilitates the migration and invasion of nasopharyngeal carcinoma cells.
    Title: TRIM11, a new target of p53, facilitates the migration and invasion of nasopharyngeal carcinoma cells.
  7. Cutaneous Melanocytic Tumor With CRTC1::TRIM11 Translocation : An Emerging Entity Analyzed in a Series of 41 Cases.
    Title: Cutaneous Melanocytic Tumor With CRTC1::TRIM11 Translocation : An Emerging Entity Analyzed in a Series of 41 Cases.
  8. Tripartite motif-containing protein 11 promotes hepatocellular carcinogenesis through ubiquitin-proteasome-mediated degradation of pleckstrin homology domain leucine-rich repeats protein phosphatase 1.
    Title: Tripartite motif-containing protein 11 promotes hepatocellular carcinogenesis through ubiquitin-proteasome-mediated degradation of pleckstrin homology domain leucine-rich repeats protein phosphatase 1.
  9. Sex-determining Region Y-box transcription factor 13 promotes breast cancer cell proliferation and glycolysis by activating the tripartite motif containing 11-mediated Wnt/beta-catenin signaling pathway.
    Title: Sex-determining Region Y-box transcription factor 13 promotes breast cancer cell proliferation and glycolysis by activating the tripartite motif containing 11-mediated Wnt/β-catenin signaling pathway.
  10. Downregulation of tripartite motif protein 11 attenuates cardiomyocyte apoptosis after ischemia/reperfusion injury via DUSP1-JNK1/2.
    Title: Downregulation of tripartite motif protein 11 attenuates cardiomyocyte apoptosis after ischemia/reperfusion injury via DUSP1-JNK1/2.
Submit: New GeneRIF Correction See all GeneRIFs (39)

Phenotypes

Go to the top of the page Help

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Gene by stress genome-wide interaction analysis and path analysis identify EBF1 as a cardiovascular and metabolic risk gene.
EBI GWAS Catalog

Variation

Go to the top of the page Help

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

Go to the top of the page Help

Protein interactions

Protein Gene Interaction Pubs
Pr55(Gag) gag HIV-1 infection is modestly restricted by human TRIM11 and downregulation of TRIM11 enhances virus release, suggesting the interaction between HIV-1 Gag and TRIM11 PubMed
Vpr vpr HIV-1 Vpr may indirectly regulate TRIM11 in a dose-dependent manner, which is independent of the ubiquitin system or VprBP-mediated pathway PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein domain specific binding IEA
Inferred from Electronic Annotation
more info
  
enables protein-macromolecule adaptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in innate immune response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in innate immune response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of AIM2 inflammasome complex assembly IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of neurogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of viral entry into host cell IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of viral entry into host cell IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of viral transcription IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in negative regulation of viral transcription IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of viral entry into host cell IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein autoubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein ubiquitination IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in regulation of gene expression IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in suppression of viral release by host IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in suppression of viral release by host IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in suppression of viral release by host IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  

General protein information

Go to the top of the page Help
Preferred Names
E3 ubiquitin-protein ligase TRIM11
Names
RING finger protein 92
RING-type E3 ubiquitin transferase TRIM11
tripartite motif-containing protein 11
NP_660215.1
XP_011542587.1
XP_016857901.1
XP_054194871.1
XP_054194872.1

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_145214.3 → NP_660215.1  E3 ubiquitin-protein ligase TRIM11

    See identical proteins and their annotated locations for NP_660215.1

    Status: REVIEWED

    Source sequence(s)
    AL670729
    Consensus CDS
    CCDS31048.1
    UniProtKB/Swiss-Prot
    A6NKE2, B2RB82, B3KUS3, B4DX88, Q5VSU1, Q8NCA6, Q96F44, Q9C022
    Related
    ENSP00000284551.6, ENST00000284551.11
    Conserved Domains (3) summary
    cd15811
    Location:288 → 456
    SPRY_PRY_TRIM11; PRY/SPRY domain of tripartite motif-binding protein 11 (TRIM11), also known as RING finger protein 92 (RNF92)
    pfam00643
    Location:87 → 128
    zf-B_box; B-box zinc finger
    cd16594
    Location:13 → 57
    RING-HC_TRIM11_like_C-IV; RING finger, HC subclass, found in tripartite motif-containing proteins, TRIM11 and TRIM27, and similar proteins

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    228393676..228406835 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011544285.4 → XP_011542587.1  E3 ubiquitin-protein ligase TRIM11 isoform X2

    Conserved Domains (3) summary
    pfam00643
    Location:87 → 128
    zf-B_box; B-box zinc finger
    pfam15227
    Location:16 → 56
    zf-C3HC4_4; zinc finger of C3HC4-type, RING
    cd15811
    Location:211 → 379
    SPRY_PRY_TRIM11; PRY/SPRY domain of tripartite motif-binding protein 11 (TRIM11), also known as RING finger protein 92 (RNF92)

  2. XM_017002412.3 → XP_016857901.1  E3 ubiquitin-protein ligase TRIM11 isoform X1

    UniProtKB/Swiss-Prot
    Q96F44
    Conserved Domains (3) summary
    pfam00643
    Location:87 → 128
    zf-B_box; B-box zinc finger
    pfam15227
    Location:16 → 56
    zf-C3HC4_4; zinc finger of C3HC4-type, RING
    cd15811
    Location:287 → 455
    SPRY_PRY_TRIM11; PRY/SPRY domain of tripartite motif-binding protein 11 (TRIM11), also known as RING finger protein 92 (RNF92)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    227582208..227595361 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054338897.1 → XP_054194872.1  E3 ubiquitin-protein ligase TRIM11 isoform X2

  2. XM_054338896.1 → XP_054194871.1  E3 ubiquitin-protein ligase TRIM11 isoform X1

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q96F44.2 GenPept UniProtKB/Swiss-Prot:Q96F44

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous