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PLA2-ALPHA Phospholipase A2 family protein [ Arabidopsis thaliana (thale cress) ]

Gene ID: 815261, updated on 18-Sep-2024

Summary

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Official Symbol
PLA2-ALPHA
Official Full Name
Phospholipase A2 family protein
Primary source
TAIR:AT2G06925
Locus tag
AT2G06925
See related
Araport:AT2G06925
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ATSPLA2-ALPHA; PHOSPHOLIPASE A2-ALPHA
Summary
Encodes a secretory phospholipase A2 enzyme, which specifically hydrolyzes the sn-2 position of phospholipids. The enzyme has a preference towards linoleoyl acyl chain over palmitoyl acyl chain. It also has a slight preference for phosphatidylcholine over phosphatidylethanolamine.
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Genomic context

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See PLA2-ALPHA in Genome Data Viewer
Location:
chromosome: 2
Exon count:
4
Sequence:
Chromosome: 2; NC_003071.7 (2842020..2843386, complement)

Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene pseudo Neighboring gene pseudo Neighboring gene miscRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Probing selected structural regions in the secreted phospholipase A₂ from Arabidopsis thaliana for their impact on stability and activity. Mansfeld J, et al. Biochimie, 2014 Jun. PMID 24389456
  2. The patatin-containing phospholipase A pPLAIIα modulates oxylipin formation and water loss in Arabidopsis thaliana. Yang WY, et al. Mol Plant, 2012 Mar. PMID 22259021, Free PMC Article
  3. Secretory phospholipase A2-alpha from Arabidopsis thaliana: functional parameters and substrate preference. Mansfeld J, et al. Chem Phys Lipids, 2007 Dec. PMID 17692835
  4. A mutation in the pPLA-IIα gene encoding PATATIN-RELATED PHOSPHOLIPASE a causes late flowering in Arabidopsis. Kwak JS, et al. Biochem Biophys Res Commun, 2021 Dec 10. PMID 34678591
  5. AtsPLA2-alpha nuclear relocalization by the Arabidopsis transcription factor AtMYB30 leads to repression of the plant defense response. Froidure S, et al. Proc Natl Acad Sci U S A, 2010 Aug 24. PMID 20696912, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. A mutation in the pPLA-IIalpha gene encoding PATATIN-RELATED PHOSPHOLIPASE a causes late flowering in Arabidopsis.
    Title: A mutation in the pPLA-IIα gene encoding PATATIN-RELATED PHOSPHOLIPASE a causes late flowering in Arabidopsis.
  2. Extended loop structures at the N-terminus in AtPLA2alpha are suggested to be the main reasons for the much lower thermodynamic stability compared with its homologues.
    Title: Probing selected structural regions in the secreted phospholipase A₂ from Arabidopsis thaliana for their impact on stability and activity.
  3. These results indicate that pPLAIIalpha negatively regulates oxylipin production and suggest a role in the removal of oxidatively modified fatty acids from membranes.
    Title: The patatin-containing phospholipase A pPLAIIα modulates oxylipin formation and water loss in Arabidopsis thaliana.
  4. AtMYB30 and the secreted phospholipase AtsPLA(2)-alpha physically interact in vivo, following the AtMYB30-mediated specific relocalization of AtsPLA(2)-alpha from cytoplasmic vesicles to the plant cell nucleus.
    Title: AtsPLA2-alpha nuclear relocalization by the Arabidopsis transcription factor AtMYB30 leads to repression of the plant defense response.
  5. analysis of secretory phospholipase A2-alpha from Arabidopsis thaliana
    Title: Secretory phospholipase A2-alpha from Arabidopsis thaliana: functional parameters and substrate preference.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

NM_001335309.1
NM_126670.3

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables phospholipase A2 activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables phospholipase A2 activity IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in arachidonate secretion IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phospholipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in extracellular region ISM
Inferred from Sequence Model
more info
  
located_in vacuole TAS
Traceable Author Statement
more info
 PubMed 

General protein information

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Preferred Names
Phospholipase A2 family protein
NP_565337.1
  • PLA2-ALPHA; FUNCTIONS IN: phospholipase A2 activity; INVOLVED IN: phospholipid metabolic process, lipid catabolic process; LOCATED IN: vacuole; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Phospholipase A2 (InterPro:IPR016090), Phospholipase A2, active site (InterPro:IPR013090), Phospholipase A2, eukaryotic (InterPro:IPR001211); BEST Arabidopsis thaliana protein match is: Phospholipase A2 family protein (TAIR:AT4G29470.1); Has 123 Blast hits to 123 proteins in 26 species: Archae - 0; Bacteria - 0; Metazoa - 13; Fungi - 0; Plants - 110; Viruses - 0; Other Eukaryotes - 0 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003071.7 Reference assembly

    Range
    2842020..2843386 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_126670.3 → NP_565337.1  Phospholipase A2 family protein [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_565337.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8S8N6
    UniProtKB/TrEMBL
    A0A178VVH8, A0A5S9WXI3
    Conserved Domains (1) summary
    cd04706
    Location:32 → 148
    PLA2_plant; Plant-specific sub-family of Phospholipase A2, a super-family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. Enzymatically active PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids; ...

  2. NM_001335309.1 → NP_001324649.1  Phospholipase A2 family protein [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8B0P3, A0A7G2E8E6
    Conserved Domains (1) summary
    cd04706
    Location:32 → 142
    PLA2_plant; Plant-specific sub-family of Phospholipase A2, a super-family of secretory and cytosolic enzymes; the latter are either Ca dependent or Ca independent. Enzymatically active PLA2 cleaves the sn-2 position of the glycerol backbone of phospholipids; ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8S8N6.1

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