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PAA2 20S proteasome subunit PAA2 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 815135, updated on 18-Sep-2024

Summary

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Official Symbol
PAA2
Official Full Name
20S proteasome subunit PAA2
Primary source
TAIR:AT2G05840
Locus tag
AT2G05840
See related
Araport:AT2G05840
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
20S proteasome subunit PAA2; T6P5.4; T6P5_4
Summary
Encodes 20S proteasome subunit PAA2 (PAA2).
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Genomic context

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See PAA2 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
9
Sequence:
Chromosome: 2; NC_003071.7 (2234019..2236470)

Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene NagB/RpiA/CoA transferase-like superfamily protein Neighboring gene pseudo Neighboring gene serine carboxypeptidase-like 38

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Clp protease system is required for copper ion-dependent turnover of the PAA2/HMA8 copper transporter in chloroplasts. Tapken W, et al. New Phytol, 2015 Jan. PMID 25262970
  2. Molecular organization of the 20S proteasome gene family from Arabidopsis thaliana. Fu H, et al. Genetics, 1998 Jun. PMID 9611183, Free PMC Article
  3. The 20S proteasome gene family in Arabidopsis thaliana. Parmentier Y, et al. FEBS Lett, 1997 Oct 27. PMID 9373170
  4. Structure and functional analysis of the 26S proteasome subunits from plants. Fu H, et al. Mol Biol Rep, 1999 Apr. PMID 10363660
  5. Affinity purification of the Arabidopsis 26 S proteasome reveals a diverse array of plant proteolytic complexes. Book AJ, et al. J Biol Chem, 2010 Aug 13. PMID 20516081, Free PMC Article

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Copper excess in the stroma triggers selection of the thylakoid-localized PAA2 transporter for degradation by the Clp protease.
    Title: The Clp protease system is required for copper ion-dependent turnover of the PAA2/HMA8 copper transporter in chloroplasts.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

NM_001036263.1
NM_001335288.1
NM_126597.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
  
Process Evidence Code Pubs
involved_in ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within ubiquitin-dependent protein catabolic process TAS
Traceable Author Statement
more info
 PubMed 
Component Evidence Code Pubs
located_in chloroplast ISM
Inferred from Sequence Model
more info
  
located_in cytoplasm ISM
Inferred from Sequence Model
more info
  
located_in cytosol HDA PubMed 
located_in cytosolic ribosome HDA PubMed 
located_in mitochondrion HDA PubMed 
part_of proteasome complex IDA
Inferred from Direct Assay
more info
 PubMed 
part_of proteasome core complex TAS
Traceable Author Statement
more info
 PubMed 
part_of proteasome core complex, alpha-subunit complex ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
20S proteasome subunit PAA2
NP_001031340.1
  • 20S proteasome subunit PAA2 (PAA2); FUNCTIONS IN: peptidase activity, endopeptidase activity, threonine-type endopeptidase activity; INVOLVED IN: ubiquitin-dependent protein catabolic process; LOCATED IN: proteasome core complex, proteasome complex, cytosolic ribosome; EXPRESSED IN: fruit, guard cell, cultured cell; EXPRESSED DURING: seed development stages; CONTAINS InterPro DOMAIN/s: Proteasome, alpha-subunit, conserved site (InterPro:IPR000426), Proteasome, subunit alpha/beta (InterPro:IPR001353); BEST Arabidopsis thaliana protein match is: proteasome alpha subunit A1 (TAIR:AT5G35590.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
NP_178641.1
  • 20S proteasome subunit PAA2 (PAA2); FUNCTIONS IN: peptidase activity, endopeptidase activity, threonine-type endopeptidase activity; INVOLVED IN: ubiquitin-dependent protein catabolic process; LOCATED IN: proteasome core complex, proteasome complex, cytosolic ribosome; EXPRESSED IN: fruit, guard cell, cultured cell; EXPRESSED DURING: seed development stages; CONTAINS InterPro DOMAIN/s: Proteasome, alpha-subunit, conserved site (InterPro:IPR000426), Proteasome, subunit alpha/beta (InterPro:IPR001353); BEST Arabidopsis thaliana protein match is: proteasome alpha subunit A1 (TAIR:AT5G35590.1); Has 5183 Blast hits to 5183 proteins in 442 species: Archae - 699; Bacteria - 0; Metazoa - 1674; Fungi - 1311; Plants - 685; Viruses - 0; Other Eukaryotes - 814 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003071.7 Reference assembly

    Range
    2234019..2236470
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_126597.4 → NP_178641.1  20S proteasome subunit PAA2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_178641.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O81147
    UniProtKB/TrEMBL
    A0A178VUX1, A0A5S9WXD7, A0A7G2FDQ8
    Conserved Domains (1) summary
    cd03754
    Location:8 → 220
    proteasome_alpha_type_6; The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on top of one another forming ...

  2. NM_001335288.1 → NP_001324458.1  20S proteasome subunit PAA2 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A1P8B073

  3. NM_001036263.1 → NP_001031340.1  20S proteasome subunit PAA2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_001031340.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    A0A7G2FDQ8, F4IIA5
    Conserved Domains (2) summary
    TIGR03633
    Location:7 → 217
    arc_protsome_A; proteasome endopeptidase complex, archaeal, alpha subunit
    cd03754
    Location:8 → 217
    proteasome_alpha_type_6; proteasome_alpha_type_6. The 20S proteasome, multisubunit proteolytic complex, is the central enzyme of nonlysosomal protein degradation in both the cytosol and nucleus. It is composed of 28 subunits arranged as four homoheptameric rings that stack on ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O81147.1

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