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MED8 mediator subunit 8 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 814836, updated on 18-Sep-2024

Summary

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Official Symbol
MED8
Official Full Name
mediator subunit 8
Primary source
TAIR:AT2G03070
Locus tag
AT2G03070
See related
Araport:AT2G03070
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
mediator subunit 8; T17M13.24; T17M13_24
Summary
Encodes a subunit of the Mediator complex. Regulates plant defense and flowering.
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Genomic context

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See MED8 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
13
Sequence:
Chromosome: 2; NC_003071.7 (905513..909272)

Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene Mitochondrial transcription termination factor family protein Neighboring gene AGAMOUS-like 30 Neighboring gene pseudo Neighboring gene expansin A15

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The Arabidopsis mediator complex subunit 8 regulates oxidative stress responses. He H, et al. Plant Cell, 2021 Jul 19. PMID 33713138, Free PMC Article
  2. MED8 regulates floral transition in Arabidopsis by interacting with FPA. Yuan C, et al. Plant J, 2023 Dec. PMID 37565662
  3. The Arabidopsis thaliana Mediator subunit MED8 regulates plant immunity to Botrytis Cinerea through interacting with the basic helix-loop-helix (bHLH) transcription factor FAMA. Li X, et al. PLoS One, 2018. PMID 29513733, Free PMC Article
  4. The mediator complex subunit PFT1 is a key regulator of jasmonate-dependent defense in Arabidopsis. Kidd BN, et al. Plant Cell, 2009 Aug. PMID 19671879, Free PMC Article
  5. The Mediator complex subunits MED25/PFT1 and MED8 are required for transcriptional responses to changes in cell wall arabinose composition and glucose treatment in Arabidopsis thaliana. Seguela-Arnaud M, et al. BMC Plant Biol, 2015 Sep 5. PMID 26341899, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The Arabidopsis mediator complex subunit 8 regulates oxidative stress responses.
    Title: The Arabidopsis mediator complex subunit 8 regulates oxidative stress responses.
  2. FAMA-overexpressed plants displayed enhanced resistance to B. cinerea infection and increased expression levels of defensin genes following B. cinerea treatment. Genetic analysis of MED8 and FAMA suggested that FAMA-regulated pathogen resistance was dependent on MED8. In addition, MED8 and FAMA were both associated with the G-box region in the promoter of ORA59.
    Title: The Arabidopsis thaliana Mediator subunit MED8 regulates plant immunity to Botrytis Cinerea through interacting with the basic helix-loop-helix (bHLH) transcription factor FAMA.
  3. MED25 and MED8 subunits of the Mediator transcriptional complex are required for the transcriptional regulation of genes involved in cell elongation and cell wall composition in response to defective cell walls and in sugar-responsive gene expression.
    Title: The Mediator complex subunits MED25/PFT1 and MED8 are required for transcriptional responses to changes in cell wall arabinose composition and glucose treatment in Arabidopsis thaliana.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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NM_126359.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within defense response to fungus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of flower development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of mediator complex IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

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Preferred Names
mediator subunit 8
NP_178407.2
  • mediator subunit 8 (MED8); Has 21670 Blast hits to 11104 proteins in 489 species: Archae - 4; Bacteria - 472; Metazoa - 8306; Fungi - 2813; Plants - 2364; Viruses - 51; Other Eukaryotes - 7660 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003071.7 Reference assembly

    Range
    905513..909272
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_126359.4 → NP_178407.2  mediator subunit 8 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_178407.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O80620, Q4V3C1
    UniProtKB/TrEMBL
    A0A7G2E761
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q4V3C1.1

Gene LinkOut

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