U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

UBC2 ubiquiting-conjugating enzyme 2 [ Arabidopsis thaliana (thale cress) ]

Gene ID: 814805, updated on 15-Oct-2023

Summary

Go to the top of the page Help
Gene symbol
UBC2
Gene description
ubiquiting-conjugating enzyme 2
Primary source
Araport:AT2G02760
Locus tag
AT2G02760
See related
TAIR:AT2G02760
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Arabidopsis thaliana (ecotype: Columbia)
Lineage
Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as
ATUBC2; T20F6.10; T20F6_10; ubiquitin-conjugating enzyme 2; ubiquiting-conjugating enzyme 2
Summary
ubiquitin conjugating enzyme UBC2. Homolog of the yeast RAD6 gene.
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See UBC2 in Genome Data Viewer
Location:
chromosome: 2
Exon count:
7
Sequence:
Chromosome: 2; NC_003071.7 (773645..775902)

Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene ssDNA-binding transcriptional regulator Neighboring gene Pentatricopeptide repeat (PPR) superfamily protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene L-aminoadipate-semialdehyde dehydrogenase-phosphopantetheinyl transferase Neighboring gene 4'-phosphopantetheinyl transferase domain protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. E2 conjugases UBC1 and UBC2 regulate MYB42-mediated SOS pathway in response to salt stress in Arabidopsis. Sun Y, et al. New Phytol, 2020 Jul. PMID 32167578
  2. Arabidopsis thaliana RAD6 homolog AtUBC2 complements UV sensitivity, but not N-end rule degradation deficiency, of Saccharomyces cerevisiae rad6 mutants. Zwirn P, et al. Curr Genet, 1997 Nov. PMID 9371881
  3. Repression of the floral transition via histone H2B monoubiquitination. Gu X, et al. Plant J, 2009 Feb. PMID 18980658
  4. The E2 ubiquitin-conjugating enzymes, AtUBC1 and AtUBC2, play redundant roles and are involved in activation of FLC expression and repression of flowering in Arabidopsis thaliana. Xu L, et al. Plant J, 2009 Jan. PMID 18798874
  5. Cellular Ubc2/Rad6 E2 ubiquitin-conjugating enzyme facilitates tombusvirus replication in yeast and plants. Imura Y, et al. Virology, 2015 Oct. PMID 26135843

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. E2 conjugases UBC1 and UBC2 regulate MYB42-mediated SOS pathway in response to salt stress in Arabidopsis.
    Title: E2 conjugases UBC1 and UBC2 regulate MYB42-mediated SOS pathway in response to salt stress in Arabidopsis.
  2. The authors demonstrate that tombusvirus RNA replication and the mono- and bi-ubiquitination level of p33 is decreased in rad6Delta yeast. However, plasmid-based expression of the Arabidopsis Ubc2p could complement both defects in rad6Delta yeast.
    Title: Cellular Ubc2/Rad6 E2 ubiquitin-conjugating enzyme facilitates tombusvirus replication in yeast and plants.
  3. UBC1 and UBC2 redundantly mediate H2B monoubiquitination, and upregulate the expression of FLC.
    Title: Repression of the floral transition via histone H2B monoubiquitination.
  4. The double mutant Atubc1-1 Atubc2-1 shows a dramatically enhanced mutant phenotype. These two genes act together with HUB1/HUB2 in H2B ubiquitylation, which is involved in the activation of floral repressor genes.
    Title: The E2 ubiquitin-conjugating enzymes, AtUBC1 and AtUBC2, play redundant roles and are involved in activation of FLC expression and repression of flowering in Arabidopsis thaliana.
Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Homology

NM_001335135.1
NM_001335136.1
NM_126331.4

Gene Ontology Provided by TAIR

Function Evidence Code Pubs
enables histone H2B deubiquitinase activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables ubiquitin conjugating enzyme activity IEA
Inferred from Electronic Annotation
more info
  
enables ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables ubiquitin-protein transferase activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Process Evidence Code Pubs
acts_upstream_of_or_within UV protection IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within ubiquitin-dependent protein catabolic process TAS
Traceable Author Statement
more info
 PubMed 
acts_upstream_of_or_within vegetative to reproductive phase transition of meristem IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus ISM
Inferred from Sequence Model
more info
  

General protein information

Go to the top of the page Help
Preferred Names
ubiquiting-conjugating enzyme 2
NP_565289.1
  • ubiquiting-conjugating enzyme 2 (UBC2); CONTAINS InterPro DOMAIN/s: Ubiquitin-conjugating enzyme/RWD-like (InterPro:IPR016135), Ubiquitin-conjugating enzyme, E2 (InterPro:IPR000608); BEST Arabidopsis thaliana protein match is: ubiquitin carrier protein 1 (TAIR:AT1G14400.2); Has 10642 Blast hits to 10588 proteins in 402 species: Archae - 0; Bacteria - 2; Metazoa - 4556; Fungi - 2331; Plants - 2015; Viruses - 26; Other Eukaryotes - 1712 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003071.7 Reference assembly

    Range
    773645..775902
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001335134.1 → NP_001325163.1  ubiquiting-conjugating enzyme 2 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P42745, Q4TZ07
    UniProtKB/TrEMBL
    A0A178W0U6, A0A5S9WWP9
    Conserved Domains (1) summary
    cd00195
    Location:7 → 145
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

  2. NM_126331.4 → NP_565289.1  ubiquiting-conjugating enzyme 2 [Arabidopsis thaliana]

    See identical proteins and their annotated locations for NP_565289.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P42745, Q4TZ07
    UniProtKB/TrEMBL
    A0A178W0U6, A0A5S9WWP9
    Conserved Domains (1) summary
    cd00195
    Location:7 → 145
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

  3. NM_001335135.1 → NP_001325164.1  ubiquiting-conjugating enzyme 2 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P42745, Q4TZ07
    UniProtKB/TrEMBL
    A0A178W0U6, A0A5S9WWP9
    Conserved Domains (1) summary
    cd00195
    Location:7 → 145
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...

  4. NM_001335136.1 → NP_001325162.1  ubiquiting-conjugating enzyme 2 [Arabidopsis thaliana]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P42745, Q4TZ07
    UniProtKB/TrEMBL
    A0A178W0U6, A0A5S9WWP9
    Conserved Domains (1) summary
    cd00195
    Location:7 → 145
    UBCc; Ubiquitin-conjugating enzyme E2, catalytic (UBCc) domain. This is part of the ubiquitin-mediated protein degradation pathway in which a thiol-ester linkage forms between a conserved cysteine and the C-terminus of ubiquitin and complexes with ubiquitin ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P42745.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools