SOS1 sodium proton exchanger, putative (NHX7) (SOS1) [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Gene symbol: SOS1
Gene description: sodium proton exchanger, putative (NHX7) (SOS1)
Primary source: Araport:AT2G01980
Locus tag: AT2G01980
See related: TAIR:AT2G01980
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ARABIDOPSIS NA+/H+ ANTIPORTER 7; ARABIDOPSIS SALT OVERLY SENSITIVE 1; ATNHX7; ATSOS1; F14H20.5; F14H20_5; SALT OVERLY SENSITIVE 1
Summary: Encodes a plasma membrane-localized Na+/H+ antiporter SOS1. Functions in the extrusion of toxic Na+ from cells and is essential for plant salt tolerance. Has 12 predicted transmembrane domains in the N-terminal region and a long cytoplasmic tail of approx. 700 aa at the C-terminal side. SOS1 interacts through its predicted cytoplasmic tail with RCD1, a regulator of oxidative-stress responses, suggesting that SOS1 might function in oxidative-stress tolerance.
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Genomic context

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See SOS1 in Genome Data Viewer

Location:: chromosome: 2

Exon count:: 23

Sequence:: Chromosome: 2; NC_003071.7 (457002..463408)

Chromosome 2 - NC_003071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Structural basis for the activity regulation of Salt Overly Sensitive 1 in Arabidopsis salt tolerance.
Title: Structural basis for the activity regulation of Salt Overly Sensitive 1 in Arabidopsis salt tolerance.
Architecture and autoinhibitory mechanism of the plasma membrane Na[+]/H[+] antiporter SOS1 in Arabidopsis.
Title: Architecture and autoinhibitory mechanism of the plasma membrane Na(+)/H(+) antiporter SOS1 in Arabidopsis.
The Na(+)/H(+) antiporter SALT OVERLY SENSITIVE 1 regulates salt compensation of circadian rhythms by stabilizing GIGANTEA in Arabidopsis.
Title: The Na(+)/H(+) antiporter SALT OVERLY SENSITIVE 1 regulates salt compensation of circadian rhythms by stabilizing GIGANTEA in Arabidopsis.
The plasma-membrane polyamine transporter PUT3 is regulated by the Na(+) /H(+) antiporter SOS1 and protein kinase SOS2.
Title: The plasma-membrane polyamine transporter PUT3 is regulated by the Na(+) /H(+) antiporter SOS1 and protein kinase SOS2.
The protein kinase complex CBL10-CIPK8-SOS1 functions in Arabidopsis to regulate salt tolerance.
Title: The protein kinase complex CBL10-CIPK8-SOS1 functions in Arabidopsis to regulate salt tolerance.
14-3-3 Proteins and Other Candidates form Protein-Protein Interactions with the Cytosolic C-terminal End of SOS1 Affecting Its Transport Activity.
Title: 14-3-3 Proteins and Other Candidates form Protein-Protein Interactions with the Cytosolic C-terminal End of SOS1 Affecting Its Transport Activity.
SOS1 mutation induced a significant decrease in transcripts of HKT1, AKT1 and SKOR under salt stress.
Title: The Effect of AtHKT1;1 or AtSOS1 Mutation on the Expressions of Na⁺ or K⁺ Transporter Genes and Ion Homeostasis in Arabidopsis thaliana under Salt Stress.
Co-overexpression of AtNHX1 and SOS1 could significantly reduce yield loss caused by the combined stresses of heat and salt, confirming the hypothesis that stacked overexpression of two genes could substantially improve tolerance against multiple stresses.
Title: Co-overexpressing a Plasma Membrane and a Vacuolar Membrane Sodium/Proton Antiporter Significantly Improves Salt Tolerance in Transgenic Arabidopsis Plants.
Standard chromatin immunoprecipitation and reporter assays suggest that TBX2 represses Oca2 at least in part directly. Hence, the results suggest that TBX2 may act as a nexus linking cell proliferation and melanogenesis
Title: Expression and characterization of the SOS1 Arabidopsis salt tolerance protein.
SOS1 mutant showed severe growth inhibition under salt shock stress owing to a single base deletion
Title: Arabidopsis sos1 mutant in a salt-tolerant accession revealed an importance of salt acclimation ability in plant salt tolerance.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_126259.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables sodium:proton antiporter activity	IEA Inferred from Electronic Annotation more info
enables sodium:proton antiporter activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within potassium ion transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in proton transmembrane transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of reactive oxygen species metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to hydrogen peroxide	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to hydrogen peroxide	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to oxidative stress	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to reactive oxygen species	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to salt stress	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within response to salt stress	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sodium ion transport	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in chloroplast envelope	HDA more info	PubMed
located_in plasma membrane	HDA more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: sodium proton exchanger, putative (NHX7) (SOS1)

NP_178307.2

SALT OVERLY SENSITIVE 1 (SOS1); FUNCTIONS IN: sodium:hydrogen antiporter activity; INVOLVED IN: in 7 processes; LOCATED IN: plasma membrane, chloroplast envelope; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Cyclic nucleotide-binding (InterPro:IPR000595), Cation/H+ exchanger, conserved region (InterPro:IPR018422), Cation/H+ exchanger (InterPro:IPR006153), Cyclic nucleotide-binding-like (InterPro:IPR018490), RmlC-like jelly roll fold (InterPro:IPR014710), Na+/H+ exchanger, isoforms 7/8, conserved region (InterPro:IPR018418); BEST Arabidopsis thaliana protein match is: Na+/H+ exchanger 8 (TAIR:AT1G14660.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003071.7 Reference assembly

Range

457002..463408

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_126259.4 → NP_178307.2 sodium proton exchanger, putative (NHX7) (SOS1) [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_178307.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9LKW9, Q9ZPS6

UniProtKB/TrEMBL

M5BEG3, M5BF34

Conserved Domains (2) summary

pfam00027
Location:764 → 843

cNMP_binding; Cyclic nucleotide-binding domain

pfam00999
Location:36 → 449

Na_H_Exchanger; Sodium/hydrogen exchanger family