WOL CHASE domain containing histidine kinase protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

Go to the top of the page Help

Official Symbol: WOL
Official Full Name: CHASE domain containing histidine kinase protein
Primary source: TAIR:AT2G01830
Locus tag: AT2G01830
See related: Araport:AT2G01830
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: AHK4; ARABIDOPSIS HISTIDINE KINASE 4; ATCRE1; CRE1; CYTOKININ RESPONSE 1; T23K3.2; T23K3_2; WOL1; WOODEN LEG; WOODEN LEG 1
Summary: Histidine kinase: cytokinin-binding receptor that transduces cytokinin signals across the plasma membrane
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See WOL in Genome Data Viewer

Location:: chromosome: 2

Exon count:: 13

Sequence:: Chromosome: 2; NC_003071.7 (362983..369707, complement)

Chromosome 2 - NC_003071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cytokinin fluoroprobe reveals multiple sites of cytokinin perception at plasma membrane and endoplasmic reticulum.
Title: Cytokinin fluoroprobe reveals multiple sites of cytokinin perception at plasma membrane and endoplasmic reticulum.
Cytokinins promote actin bundling and the resultant second rapid cell elongation through activating the signaling pathway involving the cytokinin receptors ARABIDOPSIS HISTIDINE KINASE3 (AHK3) and AHK4 and the B-type transcription factor ARABIDOPSIS RESPONSE REGULATOR2.
Title: Actin Reorganization Triggers Rapid Cell Elongation in Roots.
an important role for endogenous cytokinin biosynthesis and AHK4-mediated cytokinin signalling in the control of de novo-induced organ identity.
Title: Cytokinin signalling regulates organ identity via the AHK4 receptor in Arabidopsis.
Results show the stress physiology function of histidine kinaseS AHK2, AHK3 AND AHK4.
Title: Stress physiology functions of the Arabidopsis histidine kinase cytokinin receptors.
N6-(benzyloxymethyl)adenosine is a novel anticytokinin, an antagonist of cytokinin receptor CRE1/AHK4 of Arabidopsis.
Title: N⁶-(benzyloxymethyl)adenosine is a novel anticytokinin, an antagonist of cytokinin receptor CRE1/AHK4 of Arabidopsis.
Programmed cell death induced by cytokinin is mediated by the cytokinin receptor CRE1.
Title: Programmed cell death induced by high levels of cytokinin in Arabidopsis cultured cells is mediated by the cytokinin receptor CRE1/AHK4.
AHK2 and AHK3 signal specifically in leaf parenchyma cells, AHK3 in stomata cells, and CRE1/AHK4 in the root vasculature. CRE1/AHK4 can functionally replace AHK2 but not AHK3.
Title: The specificity of cytokinin signalling in Arabidopsis thaliana is mediated by differing ligand affinities and expression profiles of the receptors.
The sugar effect in shoots of phosphate-starved plants was particularly enhanced in the cre1 ahk3 double mutant.
Title: Interaction between phosphate-starvation, sugar, and cytokinin signaling in Arabidopsis and the roles of cytokinin receptors CRE1/AHK4 and AHK3.
growth and development of the ahk2 ahk3 ahk4 triple mutant were markedly inhibited in various tissues and organs, including the roots and leaves in the vegetative growth phase and the influorescence meristem in the reproductive phase
Title: Histidine kinase homologs that act as cytokinin receptors possess overlapping functions in the regulation of shoot and root growth in Arabidopsis.
the diverse cytokinin compounds might have specific functions in the numerous cytokinin-regulated processes, which may depend in turn on different receptors and their associated signalling pathways
Title: Two cytokinin receptors of Arabidopsis thaliana, CRE1/AHK4 and AHK3, differ in their ligand specificity in a bacterial assay.

Submit: New GeneRIF Correction See all GeneRIFs (12)

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

NM_001335080.1

Supported by ESTs:

NM_001335081.1

Supported by ESTs:

NM_001335082.1

Supported by ESTs:

NM_126244.3

Supported by ESTs:

NM_179594.2

Supported by ESTs:

NM_201667.1

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables cytokinin receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables cytokinin receptor activity	TAS Traceable Author Statement more info	PubMed
enables enzyme binding	IPI Inferred from Physical Interaction more info	PubMed
enables myosin phosphatase activity	IEA Inferred from Electronic Annotation more info
enables osmosensor activity	IGI Inferred from Genetic Interaction more info	PubMed
enables phosphoprotein phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphorelay sensor kinase activity	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein histidine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein histidine kinase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein histidine kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables transmembrane histidine kinase cytokinin receptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within carbohydrate homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to phosphate starvation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to sucrose stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within cytokinin-activated signaling pathway	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within defense response to bacterium	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within defense response to bacterium	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic root morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
NOT involved_in leaf senescence	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within osmosensory signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in phosphorelay signal transduction system	IDA Inferred from Direct Assay more info	PubMed
involved_in phosphorelay signal transduction system	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within protein phosphorylation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of meristem development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of seed germination	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of shoot system development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to water deprivation	IEP Inferred from Expression Pattern more info	PubMed
involved_in sulfate transmembrane transport	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	HDA more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info

General protein information

Go to the top of the page Help

Preferred Names: CHASE domain containing histidine kinase protein

NP_565277.1

WOODEN LEG (WOL); FUNCTIONS IN: osmosensor activity, cytokine binding, cytokinin receptor activity, protein histidine kinase activity, phosphoprotein phosphatase activity; INVOLVED IN: in 7 processes; LOCATED IN: membrane; EXPRESSED IN: 30 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Signal transduction histidine kinase, homodimeric (InterPro:IPR009082), CHASE (InterPro:IPR006189), Signal transduction histidine kinase, core (InterPro:IPR005467), ATPase-like, ATP-binding domain (InterPro:IPR003594), CheY-like (InterPro:IPR011006), Signal transduction response regulator, receiver domain (InterPro:IPR001789), Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor domain (InterPro:IPR003661), Signal transduction histidine kinase-related protein, C-terminal (InterPro:IPR004358); BEST Arabidopsis thaliana protein match is: histidine kinase 2 (TAIR:AT5G35750.1); Has 136787 Blast hits to 109703 proteins in 3011 species: Archae - 761; Bacteria - 121785; Metazoa - 32; Fungi - 2267; Plants - 2388; Viruses - 27; Other Eukaryotes - 9527 (source: NCBI BLink).

NP_849925.1

WOODEN LEG (WOL); FUNCTIONS IN: osmosensor activity, cytokine binding, cytokinin receptor activity, protein histidine kinase activity, phosphoprotein phosphatase activity; INVOLVED IN: in 7 processes; LOCATED IN: membrane; EXPRESSED IN: 30 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Signal transduction histidine kinase, homodimeric (InterPro:IPR009082), CHASE (InterPro:IPR006189), Signal transduction histidine kinase, core (InterPro:IPR005467), ATPase-like, ATP-binding domain (InterPro:IPR003594), CheY-like (InterPro:IPR011006), Signal transduction response regulator, receiver domain (InterPro:IPR001789), Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor domain (InterPro:IPR003661), Signal transduction histidine kinase-related protein, C-terminal (InterPro:IPR004358); BEST Arabidopsis thaliana protein match is: histidine kinase 2 (TAIR:AT5G35750.1); Has 134660 Blast hits to 108037 proteins in 2975 species: Archae - 759; Bacteria - 119664; Metazoa - 32; Fungi - 2267; Plants - 2388; Viruses - 27; Other Eukaryotes - 9523 (source: NCBI BLink).

NP_973396.1

WOODEN LEG (WOL); FUNCTIONS IN: osmosensor activity, cytokine binding, cytokinin receptor activity, protein histidine kinase activity, phosphoprotein phosphatase activity; INVOLVED IN: in 7 processes; LOCATED IN: membrane; EXPRESSED IN: 30 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Signal transduction histidine kinase, homodimeric (InterPro:IPR009082), CHASE (InterPro:IPR006189), Signal transduction histidine kinase, core (InterPro:IPR005467), ATPase-like, ATP-binding domain (InterPro:IPR003594), CheY-like (InterPro:IPR011006), Signal transduction response regulator, receiver domain (InterPro:IPR001789), Signal transduction histidine kinase, subgroup 1, dimerisation/phosphoacceptor domain (InterPro:IPR003661), Signal transduction histidine kinase-related protein, C-terminal (InterPro:IPR004358); BEST Arabidopsis thaliana protein match is: histidine kinase 2 (TAIR:AT5G35750.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003071.7 Reference assembly

Range

362983..369707 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_201667.1 → NP_973396.1 CHASE domain containing histidine kinase protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_973396.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A178W0T1, A0A5S9WWG0, A0A654ER67

Conserved Domains (2) summary

PRK11107
Location:435 → 1052

PRK11107; hybrid sensory histidine kinase BarA; Provisional

pfam03924
Location:177 → 359

CHASE; CHASE domain
NM_001335081.1 → NP_001324427.1 CHASE domain containing histidine kinase protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A1P8B026, A0A5S9WWG0, A0A654ER67
NM_179594.2 → NP_849925.1 CHASE domain containing histidine kinase protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_849925.1

Status: REVIEWED

UniProtKB/Swiss-Prot

A5YY60, A5YY75, Q9C5T8, Q9C5T9, Q9C5U0, Q9FDZ3, Q9SIT0

UniProtKB/TrEMBL

A0A654ER67

Conserved Domains (2) summary

PRK11107
Location:458 → 1075

PRK11107; hybrid sensory histidine kinase BarA; Provisional

pfam03924
Location:200 → 382

CHASE; CHASE domain
NM_001335080.1 → NP_001324428.1 CHASE domain containing histidine kinase protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A178W0T1, A0A5S9WWG0, A0A654ER67

Conserved Domains (2) summary

PRK11107
Location:435 → 1052

PRK11107; hybrid sensory histidine kinase BarA; Provisional

pfam03924
Location:177 → 359

CHASE; CHASE domain
NM_001335082.1 → NP_001324429.1 CHASE domain containing histidine kinase protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A178W0T1, A0A5S9WWG0, A0A654ER67

Conserved Domains (2) summary

PRK11107
Location:435 → 1052

PRK11107; hybrid sensory histidine kinase BarA; Provisional

pfam03924
Location:177 → 359

CHASE; CHASE domain
NM_126244.3 → NP_565277.1 CHASE domain containing histidine kinase protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_565277.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A178W0T1, A0A5S9WWG0, A0A654ER67

Conserved Domains (2) summary

PRK11107
Location:435 → 1052

PRK11107; hybrid sensory histidine kinase BarA; Provisional

pfam03924
Location:177 → 359

CHASE; CHASE domain