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TSIB_RS01555 SDR family oxidoreductase [ Thermococcus sibiricus MM 739 ]

Gene ID: 8095292, updated on 15-Apr-2023

Summary

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Gene symbol
TSIB_RS01555
Gene description
SDR family oxidoreductase
Locus tag
TSIB_RS01555
Gene type
protein coding
Organism
Thermococcus sibiricus MM 739 (strain: MM 739, type-material: type strain of Thermococcus sibiricus)
Lineage
Archaea; Euryarchaeota; Thermococci; Thermococcales; Thermococcaceae; Thermococcus
Old locus tag
TSIB_0319
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Genomic context

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Sequence:
NC_012883.1 (307990..308694, complement)

NC_012883.1Genomic Context describing neighboring genes Neighboring gene 50S ribosomal protein L14e Neighboring gene SDR family oxidoreductase Neighboring gene hypothetical protein Neighboring gene glycoside hydrolase family 16 protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_012883.1

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structural insight into the molecular basis of polyextremophilicity of short-chain alcohol dehydrogenase from the hyperthermophilic archaeon Thermococcus sibiricus. Bezsudnova EY, et al. Biochimie, 2012 Dec. PMID 22885278
  2. Expression, purification and crystallization of a thermostable short-chain alcohol dehydrogenase from the archaeon Thermococcus sibiricus. Lyashenko AV, et al. Acta Crystallogr Sect F Struct Biol Cryst Commun, 2010 Jun 1. PMID 20516592, Free PMC Article
  3. Characterization of a thermostable short-chain alcohol dehydrogenase from the hyperthermophilic archaeon Thermococcus sibiricus. Stekhanova TN, et al. Appl Environ Microbiol, 2010 Jun. PMID 20418438, Free PMC Article
  4. Metabolic versatility and indigenous origin of the archaeon Thermococcus sibiricus, isolated from a siberian oil reservoir, as revealed by genome analysis. Mardanov AV, et al. Appl Environ Microbiol, 2009 Jul. PMID 19447963, Free PMC Article
  5. Medium- and short-chain dehydrogenase/reductase gene and protein families : Structure-function relationships in short-chain alcohol dehydrogenases. Ladenstein R, et al. Cell Mol Life Sci, 2008 Dec. PMID 19011748

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Data suggest that the thermostability of short-chain alcohol dehydrogenase TsAdh319 is associated with the rigidity and simultaneous "resilience" of the structure provided by a compact hydrophobic core and a large number of surface ion pairs.
    Title: Structural insight into the molecular basis of polyextremophilicity of short-chain alcohol dehydrogenase from the hyperthermophilic archaeon Thermococcus sibiricus.
  2. crystals of short-chain alcohol dehydrogenase diffracted to 1.68 A resolution and belonged to space group I222, with unit-cell parameters a = 55.63, b = 83.25, c = 120.75 A
    Title: Expression, purification and crystallization of a thermostable short-chain alcohol dehydrogenase from the archaeon Thermococcus sibiricus.
  3. The enzyme is characterized as an NADPH-dependent enantioselective oxidoreductase with broad substrate specificity.
    Title: Characterization of a thermostable short-chain alcohol dehydrogenase from the hyperthermophilic archaeon Thermococcus sibiricus.
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General gene information

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Homology

General protein information

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Preferred Names
SDR family oxidoreductase
WP_015848605.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_012883.1 Reference assembly

    Range
    307990..308694 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. WP_015848605.1 SDR family oxidoreductase [Thermococcus sibiricus]

    See identical proteins and their annotated locations for WP_015848605.1

    UniProtKB/TrEMBL
    C6A190
    Conserved Domains (2) summary
    cd05233
    Location:4 → 208
    SDR_c; classical (c) SDRs
    COG4221
    Location:2 → 230
    YdfG; NADP-dependent 3-hydroxy acid dehydrogenase YdfG [Energy production and conversion]
Nucleotide Protein
Heading Accession and Version

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