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Lactb lactamase, beta [ Mus musculus (house mouse) ]

Gene ID: 80907, updated on 11-Nov-2024

Summary

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Official Symbol
Lactbprovided by MGI
Official Full Name
lactamase, betaprovided by MGI
Primary source
MGI:MGI:1933395
See related
Ensembl:ENSMUSG00000032370 AllianceGenome:MGI:1933395
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
Lact1; LACT-1; Mrpl56
Summary
Predicted to enable identical protein binding activity and peptidase activity. Predicted to be involved in proteolysis and regulation of lipid metabolic process. Located in mitochondrion. Is expressed in several structures, including early conceptus; gonad; heart; liver; and metanephros. Orthologous to human LACTB (lactamase beta). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in duodenum adult (RPKM 13.5), adrenal adult (RPKM 10.4) and 28 other tissues See more
Orthologs
human all
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Genomic context

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See Lactb in Genome Data Viewer
Location:
9 C; 9 36.23 cM
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (66862668..66882706, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (66955382..66975484, complement)

Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene RAB8B, member RAS oncogene family Neighboring gene predicted gene, 40528 Neighboring gene STARR-positive B cell enhancer ABC_E5081 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:66767210-66767393 Neighboring gene STARR-positive B cell enhancer ABC_E5082 Neighboring gene STARR-seq mESC enhancer starr_24483 Neighboring gene ribosomal protein S27-like Neighboring gene STARR-seq mESC enhancer starr_24484 Neighboring gene predicted gene, 30639 Neighboring gene VISTA enhancer mm100 Neighboring gene STARR-positive B cell enhancer ABC_E6761 Neighboring gene CapStarr-seq enhancer MGSCv37_chr9:66892840-66892949 Neighboring gene tropomyosin 1, alpha

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. MicroRNA-351-5p mediates skeletal myogenesis by directly targeting lactamase-β and is regulated by lnc-mg. Du J, et al. FASEB J, 2019 Feb. PMID 30216112
  2. Identification, genomic organization, and mRNA expression of LACTB, encoding a serine beta-lactamase-like protein with an amino-terminal transmembrane domain. Smith TS, et al. Genomics, 2001 Nov. PMID 11707067
  3. Variations in DNA elucidate molecular networks that cause disease. Chen Y, et al. Nature, 2008 Mar 27. PMID 18344982, Free PMC Article
  4. Loss of the selective autophagy receptor p62 impairs murine myeloid leukemia progression and mitophagy. Nguyen TD, et al. Blood, 2019 Jan 10. PMID 30498063
  5. Variegated gene expression caused by cell-specific long-range DNA interactions. Noordermeer D, et al. Nat Cell Biol, 2011 Jun 26. PMID 21706023, Free PMC Article

See all (28) citations in PubMed

GeneRIFs: Gene References Into Functions

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 
  • Targeted (2) 

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables identical protein binding IEA
Inferred from Electronic Annotation
more info
  
enables identical protein binding ISO
Inferred from Sequence Orthology
more info
  
enables peptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptidase activity ISO
Inferred from Sequence Orthology
more info
  
enables peptidase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
Process Evidence Code Pubs
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis ISO
Inferred from Sequence Orthology
more info
  
involved_in proteolysis ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in regulation of lipid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of lipid metabolic process ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of lipid metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in cytosol IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol ISO
Inferred from Sequence Orthology
more info
  
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
serine beta-lactamase-like protein LACTB, mitochondrial
Names
mitochondrial ribosomal protein L56
serine beta lactamase-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001411305.1 → NP_001398234.1  serine beta-lactamase-like protein LACTB, mitochondrial isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC159741, AC166370
    UniProtKB/TrEMBL
    A0A1L1SVF9
    Related
    ENSMUSP00000151155.2, ENSMUST00000215172.2

  2. NM_030717.2 → NP_109642.1  serine beta-lactamase-like protein LACTB, mitochondrial isoform 1 precursor

    See identical proteins and their annotated locations for NP_109642.1

    Status: VALIDATED

    Source sequence(s)
    AC159741, AC166370
    Consensus CDS
    CCDS40674.1
    UniProtKB/Swiss-Prot
    Q9EP89
    UniProtKB/TrEMBL
    B2RWI2, Q80UJ8
    Related
    ENSMUSP00000034929.7, ENSMUST00000034929.7
    Conserved Domains (2) summary
    pfam00144
    Location:110 → 528
    Beta-lactamase; Beta-lactamase
    pfam06459
    Location:224 → 303
    RR_TM4-6; Ryanodine Receptor TM 4-6

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000075.7 Reference GRCm39 C57BL/6J

    Range
    66862668..66882706 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9EP89.1 GenPept UniProtKB/Swiss-Prot:Q9EP89

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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