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ADAM12 ADAM metallopeptidase domain 12 [ Homo sapiens (human) ]

Gene ID: 8038, updated on 2-Nov-2024

Summary

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Official Symbol
ADAM12provided by HGNC
Official Full Name
ADAM metallopeptidase domain 12provided by HGNC
Primary source
HGNC:HGNC:190
See related
Ensembl:ENSG00000148848 MIM:602714; AllianceGenome:HGNC:190
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MCMP; MLTN; CAR10; MLTNA; MCMPMltna; ADAM12-OT1
Summary
This gene encodes a member of a family of proteins that are structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. Expression of this gene has been used as a maternal serum marker for pre-natal development. Alternative splicing results in multiple transcript variants encoding different isoforms. Shorter isoforms are secreted, while longer isoforms are membrane-bound form. [provided by RefSeq, Jan 2014]
Expression
Biased expression in placenta (RPKM 63.0), gall bladder (RPKM 5.5) and 2 other tissues See more
Orthologs
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Genomic context

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See ADAM12 in Genome Data Viewer
Location:
10q26.2
Exon count:
26
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (126012391..126388477, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (126894888..127270982, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (127700960..128077046, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene fibronectin type III and ankyrin repeat domains 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2929 Neighboring gene FANK1 antisense RNA 1 Neighboring gene G protein subunit gamma 10 pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:127731483-127732140 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:127737867-127738367 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:127763214-127764413 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:127823747-127824946 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:127836493-127836992 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:127845814-127846314 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:127846315-127846815 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:127850913-127851413 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:127863169-127863692 Neighboring gene RNA, 5S ribosomal pseudogene 328 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:127889000-127889180 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr10:127935743-127936942 Neighboring gene secretion associated Ras related GTPase 1A pseudogene 2 Neighboring gene uncharacterized LOC112267914 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr10:128113684-128114883 Neighboring gene long intergenic non-protein coding RNA 601 Neighboring gene uncharacterized LOC728158 Neighboring gene chromosome 10 open reading frame 90

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. Molecular profiling of ADAM12 gene in breast cancers. Nariţa D, et al. Rom J Morphol Embryol, 2010. PMID 21103624
  2. Adding ADAM12 in risk calculation program does not improve the detection rate of trisomies 18 and 13 in first trimester screening. Valinen Y, et al. J Matern Fetal Neonatal Med, 2012 Jun. PMID 22309076
  3. Upregulated expression of ADAM12 is associated with progression of oral squamous cell carcinoma. Uehara E, et al. Int J Oncol, 2012 May. PMID 22267082
  4. ADAM (a disintegrin and metalloprotease) 12 is expressed in rat and human brain and localized to oligodendrocytes. Bernstein HG, et al. J Neurosci Res, 2004 Feb 1. PMID 14743448
  5. Interaction of the disintegrin and cysteine-rich domains of ADAM12 with integrin alpha7beta1. Zhao Z, et al. Exp Cell Res, 2004 Aug 1. PMID 15242759

See all (231) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. ADAM12-Generated Basigin Ectodomain Binds beta1 Integrin and Enhances the Expression of Cancer-Related Extracellular Matrix Proteins.
    Title: ADAM12-Generated Basigin Ectodomain Binds β1 Integrin and Enhances the Expression of Cancer-Related Extracellular Matrix Proteins.
  2. MiR-135b-5p targets ADAM12 to suppress invasion and accelerate trophoblast apoptosis in preeclampsia.
    Title: MiR-135b-5p targets ADAM12 to suppress invasion and accelerate trophoblast apoptosis in preeclampsia.
  3. Prognostic Impact of FSTL3, ADAM12, and FAT4 in Patients of Colon Cancer: Clinicopathologic Study.
    Title: Prognostic Impact of FSTL3, ADAM12, and FAT4 in Patients of Colon Cancer: Clinicopathologic Study.
  4. ADAM12 expression is upregulated in cancer cells upon radiation and constitutes a prognostic factor in rectal cancer patients following radiotherapy.
    Title: ADAM12 expression is upregulated in cancer cells upon radiation and constitutes a prognostic factor in rectal cancer patients following radiotherapy.
  5. ADAM12 promotes the resistance of lung adenocarcinoma cells to EGFR-TKI and regulates the immune microenvironment by activating PI3K/Akt/mTOR and RAS signaling pathways.
    Title: ADAM12 promotes the resistance of lung adenocarcinoma cells to EGFR-TKI and regulates the immune microenvironment by activating PI3K/Akt/mTOR and RAS signaling pathways.
  6. ADAM Metallopeptidase Domain 12 Facilitates Colorectal Cancer Progression by Inhibiting Hippo Signaling Pathway Activity.
    Title: ADAM Metallopeptidase Domain 12 Facilitates Colorectal Cancer Progression by Inhibiting Hippo Signaling Pathway Activity.
  7. ADAM12 promotes gemcitabine resistance by activating EGFR signaling pathway and induces EMT in bladder cancer.
    Title: ADAM12 promotes gemcitabine resistance by activating EGFR signaling pathway and induces EMT in bladder cancer.
  8. The association between ADAM12 gene polymorphisms and osteoarthritis: an updated meta-analysis.
    Title: The association between ADAM12 gene polymorphisms and osteoarthritis: an updated meta-analysis.
  9. ADAM12 promotes clear cell renal cell carcinoma progression and triggers EMT via EGFR/ERK signaling pathway.
    Title: ADAM12 promotes clear cell renal cell carcinoma progression and triggers EMT via EGFR/ERK signaling pathway.
  10. Expression of ADAM12 in Gastric Cancer and its Relation to Tumor Cell Behavior and Prognosis.
    Title: Expression of ADAM12 in Gastric Cancer and its Relation to Tumor Cell Behavior and Prognosis.
Submit: New GeneRIF Correction See all GeneRIFs (162)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans.
EBI GWAS Catalog
Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
EBI GWAS Catalog
Genome-wide association study of endometrial cancer in E2C2.
EBI GWAS Catalog
Genome-wide association study of monoamine metabolite levels in human cerebrospinal fluid.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Clone Names

  • FLJ31066

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables SH3 domain binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables metalloendopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables metallopeptidase activity TAS
Traceable Author Statement
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell adhesion IEA
Inferred from Electronic Annotation
more info
  
involved_in myoblast fusion TAS
Traceable Author Statement
more info
 PubMed 
involved_in positive regulation of angiogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in extracellular region IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
disintegrin and metalloproteinase domain-containing protein 12
Names
meltrin-alpha
metalloprotease-disintegrin 12 transmembrane

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029050.1 RefSeqGene

    Range
    5082..381168
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001288973.2 → NP_001275902.1  disintegrin and metalloproteinase domain-containing protein 12 isoform 3 preproprotein

    See identical proteins and their annotated locations for NP_001275902.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The encoded isoform (3, also known as ADAM12-La) is shorter than isoform 1.
    Source sequence(s)
    AC063963, AK055628, KF444157
    Consensus CDS
    CCDS91373.1
    UniProtKB/TrEMBL
    Q5JRP2, U5NE98
    Related
    ENSP00000391268.2, ENST00000448723.2
    Conserved Domains (5) summary
    smart00050
    Location:436 → 504
    DISIN; Homologues of snake disintegrins
    smart00608
    Location:507 → 649
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:211 → 411
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam01421
    Location:211 → 413
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:60 → 158
    Pep_M12B_propep; Reprolysin family propeptide

  2. NM_001288974.2 → NP_001275903.1  disintegrin and metalloproteinase domain-containing protein 12 isoform 4 preproprotein

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) uses an alternate in-frame splice site in the 5' coding region, lacks multiple 3' coding exons, and contains an alternate 3' terminal exon, resulting in a different 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (4) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AY358878, BC060804, CB960379, T91975
    UniProtKB/TrEMBL
    A8K6G4
    Conserved Domains (5) summary
    smart00050
    Location:436 → 504
    DISIN; Homologues of snake disintegrins
    smart00608
    Location:507 → 649
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:211 → 411
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam01421
    Location:211 → 413
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:60 → 158
    Pep_M12B_propep; Reprolysin family propeptide

  3. NM_001288975.2 → NP_001275904.1  disintegrin and metalloproteinase domain-containing protein 12 isoform 5 preproprotein

    See identical proteins and their annotated locations for NP_001275904.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses an alternate in-frame splice site in the 5' coding region, lacks multiple 3' coding exons, and contains an alternate 3' terminal exon, resulting in a different 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (5) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AK291629, AY358878, BC060804, CB960379, DA863951, T91975
    UniProtKB/TrEMBL
    A8K6G4
    Conserved Domains (5) summary
    smart00050
    Location:436 → 504
    DISIN; Homologues of snake disintegrins
    smart00608
    Location:507 → 649
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:211 → 411
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam01421
    Location:211 → 413
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:60 → 158
    Pep_M12B_propep; Reprolysin family propeptide

  4. NM_003474.6 → NP_003465.3  disintegrin and metalloproteinase domain-containing protein 12 isoform 1 preproprotein

    See identical proteins and their annotated locations for NP_003465.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1, also known as ADAM12-Lb).
    Source sequence(s)
    AC063963, AF023476, AK055628, BC060804, DA027173, DR004947
    Consensus CDS
    CCDS7653.1
    UniProtKB/Swiss-Prot
    O43184, O60470, Q5JRP0, Q5JRP1, Q6P9E3, Q6UWB0
    Related
    ENSP00000357668.4, ENST00000368679.8
    Conserved Domains (5) summary
    smart00050
    Location:439 → 507
    DISIN; Homologues of snake disintegrins
    smart00608
    Location:510 → 652
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:214 → 414
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam01421
    Location:214 → 416
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:60 → 161
    Pep_M12B_propep; Reprolysin family propeptide

  5. NM_021641.5 → NP_067673.2  disintegrin and metalloproteinase domain-containing protein 12 isoform 2 preproprotein

    See identical proteins and their annotated locations for NP_067673.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks multiple 3' coding exons and contains an alternate 3' terminal exon, resulting in a different 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2, also known as ADAM12-S) has a distinct C-terminus and is shorter than isoform 1.
    Source sequence(s)
    AF023476, AK291629, AY358878, BC060804, DR004947, T91975
    Consensus CDS
    CCDS7654.1
    UniProtKB/TrEMBL
    A8K6G4
    Related
    ENSP00000357665.4, ENST00000368676.8
    Conserved Domains (5) summary
    smart00050
    Location:439 → 507
    DISIN; Homologues of snake disintegrins
    smart00608
    Location:510 → 652
    ACR; ADAM Cysteine-Rich Domain
    cd04269
    Location:214 → 414
    ZnMc_adamalysin_II_like; Zinc-dependent metalloprotease; adamalysin_II_like subfamily. Adamalysin II is a snake venom zinc endopeptidase. This subfamily contains other snake venom metalloproteinases, as well as membrane-anchored metalloproteases belonging to the ADAM family. ...
    pfam01421
    Location:214 → 416
    Reprolysin; Reprolysin (M12B) family zinc metalloprotease
    pfam01562
    Location:60 → 161
    Pep_M12B_propep; Reprolysin family propeptide

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    126012391..126388477 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017016706.2 → XP_016872195.1  disintegrin and metalloproteinase domain-containing protein 12 isoform X1

  2. XM_024448210.1 → XP_024303978.1  disintegrin and metalloproteinase domain-containing protein 12 isoform X2

    Conserved Domains (3) summary
    smart00050
    Location:2 → 61
    DISIN; Homologues of snake disintegrins
    smart00608
    Location:64 → 206
    ACR; ADAM Cysteine-Rich Domain
    cl26464
    Location:308 → 459
    Atrophin-1; Atrophin-1 family

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    126894888..127270982 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054366836.1 → XP_054222811.1  disintegrin and metalloproteinase domain-containing protein 12 isoform X3

  2. XM_054366837.1 → XP_054222812.1  disintegrin and metalloproteinase domain-containing protein 12 isoform X1

  3. XM_054366838.1 → XP_054222813.1  disintegrin and metalloproteinase domain-containing protein 12 isoform X2

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O43184.3 GenPept UniProtKB/Swiss-Prot:O43184

Gene LinkOut

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