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CALCR calcitonin receptor [ Homo sapiens (human) ]

Gene ID: 799, updated on 14-Nov-2024

Summary

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Official Symbol
CALCRprovided by HGNC
Official Full Name
calcitonin receptorprovided by HGNC
Primary source
HGNC:HGNC:1440
See related
Ensembl:ENSG00000004948 MIM:114131; AllianceGenome:HGNC:1440
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CRT; CTR; CT-R; CTR1
Summary
This gene encodes a high affinity receptor for the peptide hormone calcitonin and belongs to a subfamily of seven transmembrane-spanning G protein-coupled receptors. The encoded protein is involved in maintaining calcium homeostasis and in regulating osteoclast-mediated bone resorption. Polymorphisms in this gene have been associated with variations in bone mineral density and onset of osteoporosis. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]
Expression
Low expression observed in reference dataset See more
Orthologs
mouse all
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Genomic context

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See CALCR in Genome Data Viewer
Location:
7q21.3
Exon count:
17
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (93424486..93574724, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (94666953..94817060, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (93053798..93204036, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene HEPACAM family member 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26281 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26282 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26283 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26284 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:92890341-92890842 Neighboring gene VPS50 subunit of EARP/GARPII complex Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:93025621-93026134 Neighboring gene microRNA 653 Neighboring gene microRNA 489 Neighboring gene uncharacterized LOC105375400 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:93269066-93269819 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr7:93273367-93274230 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr7:93274231-93275094 Neighboring gene ribosomal protein S27 pseudogene 17 Neighboring gene microRNA 4652

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. CALCR exacerbates renal cell carcinoma progression via stabilizing CD44.
    Title: CALCR exacerbates renal cell carcinoma progression via stabilizing CD44.
  2. Calcitonin/PAC1 receptor splice variants: a blind spot in migraine research.
    Title: Calcitonin/PAC(1) receptor splice variants: a blind spot in migraine research.
  3. Polymorphisms in Genes Encoding VDR, CALCR and Antioxidant Enzymes as Predictors of Bone Tissue Condition in Young, Healthy Men.
    Title: Polymorphisms in Genes Encoding VDR, CALCR and Antioxidant Enzymes as Predictors of Bone Tissue Condition in Young, Healthy Men.
  4. Association of TRPV5, CASR, and CALCR genetic variants with kidney stone disease susceptibility in Egyptians through main effects and gene-gene interactions.
    Title: Association of TRPV5, CASR, and CALCR genetic variants with kidney stone disease susceptibility in Egyptians through main effects and gene-gene interactions.
  5. Copper(II) import and reduction are dependent on His-Met clusters in the extracellular amino terminus of human copper transporter-1.
    Title: Copper(II) import and reduction are dependent on His-Met clusters in the extracellular amino terminus of human copper transporter-1.
  6. Dynamical interplay between the human high-affinity copper transporter hCtr1 and its cognate metal ion.
    Title: Dynamical interplay between the human high-affinity copper transporter hCtr1 and its cognate metal ion.
  7. Gender-Dependent Reference Range of Serum Calcitonin Levels in Healthy Korean Adults.
    Title: Gender-Dependent Reference Range of Serum Calcitonin Levels in Healthy Korean Adults.
  8. Genetic Depletion of Amylin/Calcitonin Receptors Improves Memory and Learning in Transgenic Alzheimer's Disease Mouse Models.
    Title: Genetic Depletion of Amylin/Calcitonin Receptors Improves Memory and Learning in Transgenic Alzheimer's Disease Mouse Models.
  9. CALCR knockdown inhibits the development and progression of non-small-cell lung cancer.
    Title: CALCR knockdown inhibits the development and progression of non-small-cell lung cancer.
  10. CALCR rs1801197 might be associated with increased risk of calcium stone urolithiasis. There is insufficient data to fully confirm the association between CALCR rs1042138 and calcium stone urolithiasis susceptibility (Meta-Analysis)
    Title: Association between calcitonin receptor gene polymorphisms and calcium stone urolithiasis: A meta-analysis.
Submit: New GeneRIF Correction See all GeneRIFs (45)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description Tests
Osteoporosis
MedGen: C0029456 OMIM: 166710 GeneReviews: Not available
Compare labs

EBI GWAS Catalog

Description
New loci associated with birth weight identify genetic links between intrauterine growth and adult height and metabolism.
EBI GWAS Catalog

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat and RANKL/M-CSF enhance osteoclast differentiation and activity by increasing osteoclast differentiation markers, such as cathepsin K and calcitonin receptor PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables amylin receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables amylin receptor activity IGI
Inferred from Genetic Interaction
more info
 PubMed 
enables amylin receptor activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables amyloid-beta binding IDA
Inferred from Direct Assay
more info
 PubMed 
NOT enables calcitonin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables calcitonin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables calcitonin binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables calcitonin family receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables calcitonin gene-related peptide receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables calcitonin gene-related peptide receptor activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables calcitonin receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables calcitonin receptor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in adenylate cyclase-activating G protein-coupled receptor signaling pathway NAS
Non-traceable Author Statement
more info
 PubMed 
involved_in amylin receptor 1 signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in amylin receptor 2 signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in amylin receptor 3 signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in amylin receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in amylin receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in calcitonin family receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in calcitonin gene-related peptide receptor signaling pathway IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cell surface receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in negative regulation of ossification IEA
Inferred from Electronic Annotation
more info
  
involved_in ossification IEA
Inferred from Electronic Annotation
more info
  
involved_in osteoclast differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of ERK1 and ERK2 cascade IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of cAMP/PKA signal transduction IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of calcium-mediated signaling IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of cytosolic calcium ion concentration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of cytosolic calcium ion concentration IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of gene expression IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in regulation of mRNA stability IEA
Inferred from Electronic Annotation
more info
  
involved_in response to amyloid-beta IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in response to glucocorticoid IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in acrosomal vesicle IEA
Inferred from Electronic Annotation
more info
  
part_of amylin receptor complex 1 IDA
Inferred from Direct Assay
more info
 PubMed 
part_of amylin receptor complex 2 IDA
Inferred from Direct Assay
more info
 PubMed 
part_of amylin receptor complex 3 IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in axon IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cilium IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane NAS
Non-traceable Author Statement
more info
 PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
  

General protein information

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Preferred Names
calcitonin receptor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_013005.1 RefSeqGene

    Range
    5007..155245
    Download
    GenBank, FASTA, Sequence Viewer (Graphics), LRG_1037

mRNA and Protein(s)

  1. NM_001164737.3 → NP_001158209.2  calcitonin receptor isoform 1 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC003078, AK313996, L00587
    Consensus CDS
    CCDS55125.2
    UniProtKB/TrEMBL
    A0A0A0MSQ7, D8MIV1
    Related
    ENSP00000497687.1, ENST00000649521.1
    Conserved Domains (2) summary
    pfam02793
    Location:69 → 137
    HRM; Hormone receptor domain
    cd15274
    Location:145 → 424
    7tmB1_calcitonin_R; calcitonin receptor, member of the class B family of seven-transmembrane G protein-coupled receptors

  2. NM_001164738.2 → NP_001158210.1  calcitonin receptor isoform 2 precursor

    See identical proteins and their annotated locations for NP_001158210.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Variants 2 and 3 encode the same isoform (2).
    Source sequence(s)
    AB022178, AC003078
    Consensus CDS
    CCDS5631.1
    UniProtKB/Swiss-Prot
    A0A0C4DG16, A4D1G6, F5H605, O14585, P30988, Q13941, Q5ZGL8, Q659U6, Q6DJU8, Q6T712
    UniProtKB/TrEMBL
    D8MIV1
    Related
    ENSP00000377959.1, ENST00000394441.5
    Conserved Domains (2) summary
    pfam00002
    Location:145 → 387
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02793
    Location:69 → 137
    HRM; Hormone receptor domain

  3. NM_001742.4 → NP_001733.1  calcitonin receptor isoform 2 precursor

    See identical proteins and their annotated locations for NP_001733.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and lacks an alternate in-frame exon in the 5' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1. Variants 2 and 3 encode the same isoform (2).
    Source sequence(s)
    AC003078, AC005024, AK313996
    Consensus CDS
    CCDS5631.1
    UniProtKB/Swiss-Prot
    A0A0C4DG16, A4D1G6, F5H605, O14585, P30988, Q13941, Q5ZGL8, Q659U6, Q6DJU8, Q6T712
    UniProtKB/TrEMBL
    D8MIV1
    Related
    ENSP00000389295.1, ENST00000426151.7
    Conserved Domains (2) summary
    pfam00002
    Location:145 → 387
    7tm_2; 7 transmembrane receptor (Secretin family)
    pfam02793
    Location:69 → 137
    HRM; Hormone receptor domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    93424486..93574724 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    94666953..94817060 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P30988.4 GenPept UniProtKB/Swiss-Prot:P30988

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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