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crppa CDP-L-ribitol pyrophosphorylase A [ Danio rerio (zebrafish) ]

Gene ID: 798716, updated on 17-Sep-2024

Summary

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Official Symbol
crppaprovided by ZNC
Official Full Name
CDP-L-ribitol pyrophosphorylase Aprovided by ZNC
Primary source
ZFIN:ZDB-GENE-061110-16
See related
Ensembl:ENSDARG00000005034 AllianceGenome:ZFIN:ZDB-GENE-061110-16
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Danio rerio
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as
ispd; sb:eu371; zgc:154151
Summary
Predicted to enable D-ribitol-5-phosphate cytidylyltransferase activity and protein homodimerization activity. Involved in protein O-linked mannosylation. Acts upstream of or within brain morphogenesis; muscle cell development; and regulation of protein glycosylation. Predicted to be located in cytoplasm. Predicted to be active in cytosol. Used to study Walker-Warburg syndrome. Human ortholog(s) of this gene implicated in autosomal recessive limb-girdle muscular dystrophy type 2U and congenital muscular dystrophy-dystroglycanopathy A7. Orthologous to human CRPPA (CDP-L-ribitol pyrophosphorylase A). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
human mouse all
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Genomic context

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See crppa in Genome Data Viewer
Location:
chromosome: 15
Exon count:
11
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCz11 (GCF_000002035.6) 15 NC_007126.7 (34495056..34568705, complement)
105 previous assembly GRCz10 (GCF_000002035.5) 15 NC_007126.6 (34637087..34710736, complement)

Chromosome 15 - NC_007126.7Genomic Context describing neighboring genes Neighboring gene alkylglycerol monooxygenase Neighboring gene mesenchyme homeobox 2a Neighboring gene sclerostin domain containing 1a Neighboring gene leucine rich repeat containing 72 Neighboring gene ankyrin repeat and MYND domain containing 2a Neighboring gene tetraspanin 13a

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
  • BioProject: PRJEB1986
  • Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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Related articles in PubMed

  1. Mutations in ISPD cause Walker-Warburg syndrome and defective glycosylation of α-dystroglycan. Roscioli T, et al. Nat Genet, 2012 May. PMID 22522421, Free PMC Article
  2. Candidate risk genes for bipolar disorder are highly conserved during evolution and highly interconnected. Franklin C, et al. Bipolar Disord, 2021 Jun. PMID 32959503
  3. A limb-girdle muscular dystrophy 2I model of muscular dystrophy identifies corrective drug compounds for dystroglycanopathies. Serafini PR, et al. JCI Insight, 2018 Sep 20. PMID 30232282, Free PMC Article
  4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Clone Names

  • MGC154151

Gene Ontology Provided by ZFIN

Function Evidence Code Pubs
enables D-ribitol-5-phosphate cytidylyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables D-ribitol-5-phosphate cytidylyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables D-ribitol-5-phosphate cytidylyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables cytidylyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within brain morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within isoprenoid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within muscle cell development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein O-linked mannosylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein O-linked mannosylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within regulation of protein glycosylation IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_or_within regulation of protein glycosylation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol ISS
Inferred from Sequence or Structural Similarity
more info
  

General protein information

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Preferred Names
D-ribitol-5-phosphate cytidylyltransferase
Names
2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase-like protein
isoprenoid synthase domain containing
isoprenoid synthase domain-containing protein
notch1-induced protein
NP_001071270.1
XP_005157821.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001077802.1 → NP_001071270.1  D-ribitol-5-phosphate cytidylyltransferase

    See identical proteins and their annotated locations for NP_001071270.1

    Status: PROVISIONAL

    Source sequence(s)
    BC127405
    UniProtKB/Swiss-Prot
    A0JPF9, E9QIE3, F1R603
    Related
    ENSDARP00000025837.5, ENSDART00000003192.7
    Conserved Domains (1) summary
    cd02516
    Location:69 → 294
    CDP-ME_synthetase; CDP-ME synthetase is involved in mevalonate-independent isoprenoid production

RefSeqs of Annotated Genomes: GCF_000002035.6-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

  1. NC_007126.7 Reference GRCz11 Primary Assembly

    Range
    34495056..34568705 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005157764.5 → XP_005157821.1  D-ribitol-5-phosphate cytidylyltransferase isoform X1

    UniProtKB/Swiss-Prot
    A0JPF9, E9QIE3, F1R603
    Related
    ENSDARP00000118574.1, ENSDART00000140882.2
    Conserved Domains (1) summary
    cd02516
    Location:55 → 280
    CDP-ME_synthetase; CDP-ME synthetase is involved in mevalonate-independent isoprenoid production
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
A0JPF9.2 GenPept UniProtKB/Swiss-Prot:A0JPF9

Gene LinkOut

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