AGBL2 AGBL carboxypeptidase 2 [Homo sapiens (human)] - Gene

Summary

Official Symbol: AGBL2provided by HGNC
Official Full Name: AGBL carboxypeptidase 2provided by HGNC
Primary source: HGNC:HGNC:26296
See related: Ensembl:ENSG00000165923 MIM:617345; AllianceGenome:HGNC:26296
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CCP2
Summary: Predicted to enable metallocarboxypeptidase activity. Predicted to be involved in protein side chain deglutamylation. Located in centriole and ciliary basal body. [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in testis (RPKM 8.5), lung (RPKM 1.3) and 7 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 11p11.2

Exon count:: 19

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	11	NC_000011.10 (47659591..47715369, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	11	NC_060935.1 (47824574..47880377, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	11	NC_000011.9 (47681143..47736921, complement)

Chromosome 11 - NC_000011.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Expression of RARRES1 and AGBL2 and progression of conventional renal cell carcinoma.
Title: Expression of RARRES1 and AGBL2 and progression of conventional renal cell carcinoma.
Findings suggest that ATP/GTP binding protein like 2 (AGBL2) plays a critical oncogenic role in the pathogenesis of hepatocellular carcinoma (HCC) through modulation on immunity-related GTPase family, M protein (IRGM)-regulated autophagy and aurora kinase A (Aurora A) activity.
Title: AGBL2 promotes cancer cell growth through IRGM-regulated autophagy and enhanced Aurora A activity in hepatocellular carcinoma.
Suggest role for AGBL2 in cell proliferation and chemotherapy resistance in gastric cancer.
Title: Effects of AGBL2 on cell proliferation and chemotherapy resistance of gastric cancer.
High AGBL2 expression is associated with breast cancer.
Title: Clinical implications of AGBL2 expression and its inhibitor latexin in breast cancer.
RARRES1, its interacting partners AGBL2, Eg5/KIF11, another EEY-bearing protein (EB1), and the microtubule tyrosination cycle are important in tumorigenesis.
Title: Tumor suppressor RARRES1 interacts with cytoplasmic carboxypeptidase AGBL2 to regulate the α-tubulin tyrosination cycle.

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide analysis of multi-ancestry cohorts identifies new loci influencing intraocular pressure and susceptibility to glaucoma. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH121749 (e-PCR)
- UniSTS:134493

RH99144 (e-PCR)
- UniSTS:85129

RH48286 (e-PCR)
- UniSTS:7372

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables metallocarboxypeptidase activity	IBA Inferred from Biological aspect of Ancestor more info
enables metallocarboxypeptidase activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables tubulin binding	IBA Inferred from Biological aspect of Ancestor more info
enables zinc ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in protein side chain deglutamylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in proteolysis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in centriole	IBA Inferred from Biological aspect of Ancestor more info
located_in centriole	IDA Inferred from Direct Assay more info	PubMed
located_in ciliary basal body	IDA Inferred from Direct Assay more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
is_active_in microtubule cytoskeleton	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: cytosolic carboxypeptidase 2

Names: ATP/GTP binding protein like 2; cytoplasmic carboxypeptidase 2; protein deglutamylase CCP2; testis tissue sperm-binding protein Li 96mP

NP_079059.2

EC 3.4.17.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_024783.4 → NP_079059.2 cytosolic carboxypeptidase 2

See identical proteins and their annotated locations for NP_079059.2

Status: VALIDATED

Source sequence(s)

AC021443, BC036234

Consensus CDS

CCDS7944.1

UniProtKB/Swiss-Prot

A8MPX2, Q53FV5, Q5U5Z8, Q8IV57, Q9H5C0

UniProtKB/TrEMBL

A0A140VKH9, A0AAG2TLR7

Related

ENSP00000435582.1, ENST00000525123.6

Conserved Domains (2) summary

cd06907
Location:407 → 666

M14_AGBL2-3_like; Peptidase M14-like domain of ATP/GTP binding protein AGBL-2 and AGBL-3, and related proteins

pfam13900
Location:105 → 120

GVQW; Putative domain of unknown function